scholarly journals Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways

Oncogene ◽  
2014 ◽  
Vol 34 (15) ◽  
pp. 1928-1937 ◽  
Author(s):  
M V Bais ◽  
G B Ozdener ◽  
G E Sonenshein ◽  
P C Trackman
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Tumor Suppressor ◽  
Lysyl Oxidase ◽  
Xenograft Growth ◽  
Repair Pathways ◽  
Lysyl Oxidase Propeptide

scholarly journals Aberrations of DNA Repair Pathways in Prostate Cancer: Future Implications for Clinical Practice?

2018 ◽  
Vol 6 ◽  
Author(s):  
Orazio Caffo ◽  
Antonello Veccia ◽  
Stefania Kinspergher ◽  
Mimma Rizzo ◽  
Francesca Maines
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Clinical Practice ◽  
Repair Pathways

scholarly journals The Tumor Suppressor Activity of the Lysyl Oxidase Propeptide Reverses the Invasive Phenotype of Her-2/neu–Driven Breast Cancer

2007 ◽  
Vol 67 (3) ◽  
pp. 1105-1112 ◽  
Author(s):  
Chengyin Min ◽  
Kathrin H. Kirsch ◽  
Yingshe Zhao ◽  
Sébastien Jeay ◽  
Amitha H. Palamakumbura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Lysyl Oxidase ◽  
Suppressor Activity ◽  
Invasive Phenotype ◽  
Tumor Suppressor Activity ◽  
Her 2 ◽  
Lysyl Oxidase Propeptide

Germline and Somatic Defects in DNA Repair Pathways in Prostate Cancer

2019 ◽  
pp. 279-300 ◽  
Author(s):  
Sara Arce ◽  
Alejandro Athie ◽  
Colin C. Pritchard ◽  
Joaquin Mateo
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Repair Pathways

scholarly journals Gut Microbiota Dysbiosis Accelerates Prostate Cancer Progression Through Increased LPCAT1 Expression and Enhanced DNA Repair Pathways

2021 ◽  
Vol 11 ◽  
Author(s):  
Yufei Liu ◽  
Chen Yang ◽  
Zheyu Zhang ◽  
Haowen Jiang
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Gut Microbiota ◽  
Cancer Progression ◽  
Fecal Microbiota Transplantation ◽  
Gene Set Enrichment Analysis ◽  
Castration Resistant Prostate Cancer ◽  
Fecal Suspension ◽  
Repair Pathways ◽  
Gut Microbiota Dysbiosis

Gut microbiota dysbiosis is related to cancer development and progression. Our previous study showed that Ruminococcus was more abundant in CRPC (Castration-resistant prostate cancer) than HSPC (Hormone-sensitive prostate cancer) individuals. Here, we determined the potential mechanism of microbiota dysbiosis in prostate cancer (PCa) progression. Metagenomics was used to verify the gut microbial discrepancies between CRPC and HSPC individuals. Fecal microbiota transplantation (FMT) was performed by transferring the fecal suspension of CRPC or HSPC individuals to TRAMP mice. Afterwards, the mice’s prostate histopathology and gut microbiota composition were determined. Since Ruminococcus was demonstrated to correlate with phospholipid metabolism, we used lipidomics to examine the mice’s fecal lipid profiles. The expression of LPCAT1 the key enzyme for phospholipid remodeling in mice prostate was also examined. Meanwhile, both microbial functions prediction and LPCAT1 GSEA analysis (Gene Set Enrichment Analysis) indicated DNA repair pathways, we further determined the expressions of RAD51 and DNA-PKcs in mice prostate. The results showed that gut Ruminococcus was significantly more abundant in CRPC individuals. FMT using CRPC feces accelerated mice’s PCa progression and increased their gut Ruminococcus abundance. Majority of fecal lipids including lysophosphatidylcholine and phosphatidylcholine were upregulated in CRPC FMT treated mice, accompanied with enhanced expressions of LPCAT1, RAD51, and DNA-PKcs in mice prostate. We reported an abundant colonization of Ruminococcus in the gut of CRPC individuals and mice receiving their fecal suspensions, and revealed the promotive capability of Ruminococcus in PCa progression via upregulating LPCAT1 and DNA repair protein expressions. The bacterium and its downstream pathways may become the targets of therapies for PCa in the future.

scholarly journals Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling

Oncogene ◽  
2009 ◽  
Vol 28 (38) ◽  
pp. 3390-3400 ◽  
Author(s):  
A H Palamakumbura ◽  
S R Vora ◽  
M A Nugent ◽  
K H Kirsch ◽  
G E Sonenshein ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Lysyl Oxidase ◽  
Cell Binding ◽  
Cancer Cell Growth ◽  
Lysyl Oxidase Propeptide

scholarly journals Aberrations of DNA repair pathways in prostate cancer: A cornerstone of precision oncology

2021 ◽  
Author(s):  
Stergios Boussios ◽  
Elie Rassy ◽  
Sidrah Shah ◽  
Evangelia Ioannidou ◽  
Matin Sheriff ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Precision Oncology ◽  
Repair Pathways
Sign in / Sign up

Export Citation Format

Share Document