scholarly journals Investigation of the Antibacterial Activity and in vivo Cytotoxicity of Biogenic Silver Nanoparticles as Potent Therapeutics

2019 ◽  
Vol 7 ◽  
Author(s):  
Md. Monir Hossain ◽  
Shakil Ahmed Polash ◽  
Masato Takikawa ◽  
Razib Datta Shubhra ◽  
Tanushree Saha ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Biogenic Silver Nanoparticles ◽  
In Vivo Cytotoxicity

scholarly journals Evaluation of cytotoxicity, immune compatibility and antibacterial activity of biogenic silver nanoparticles

2016 ◽  
Vol 205 (6) ◽  
pp. 603-613 ◽  
Author(s):  
M. Składanowski ◽  
P. Golinska ◽  
K. Rudnicka ◽  
H. Dahm ◽  
M. Rai
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Biogenic Silver Nanoparticles

Antibacterial Activity of Biogenic Silver Nanoparticles Produced by Aspergillus terreus

2015 ◽  
Vol 11 (7) ◽  
pp. 858-863 ◽  
Author(s):  
Shaban R.M. Sayed ◽  
Ali H. Bahkali ◽  
Marwa M. Bakri ◽  
Abdurahman H. Hirad ◽  
Abdallah M. Elgorban ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Aspergillus Terreus ◽  
Biogenic Silver Nanoparticles

scholarly journals Molecular insight to influential role of Hha–TomB toxin–antitoxin system for antibacterial activity of biogenic silver nanoparticles

2018 ◽  
Vol 46 (sup3) ◽  
pp. S572-S584 ◽  
Author(s):  
Prajita Paul ◽  
SureshK. Verma ◽  
Pritam Kumar Panda ◽  
Sangeeta Jaiswal ◽  
Bikash R. Sahu ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Biogenic Silver Nanoparticles

Synthesis of Biogenic Silver Nanoparticles Using Caesalpinia digyna and Investigation of Their Antimicrobial Activity and In Vivo Biocompatibility

2020 ◽  
Vol 3 (11) ◽  
pp. 7722-7733
Author(s):  
Mahruba Sultana Niloy ◽  
Md. Monir Hossain ◽  
Masato Takikawa ◽  
Md. Salman Shakil ◽  
Shakil Ahmed Polash ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Biogenic Silver Nanoparticles

scholarly journals Interaction of Silver Nanoparticles with Serum Proteins Affects Their Antimicrobial ActivityIn Vivo

2013 ◽  
Vol 57 (10) ◽  
pp. 4945-4955 ◽  
Author(s):  
Divya Prakash Gnanadhas ◽  
Midhun Ben Thomas ◽  
Rony Thomas ◽  
Ashok M. Raichur ◽  
Dipshikha Chakravortty
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Serum Albumin ◽  
Serum Proteins ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
Resistant Bacteria ◽  
Human Society ◽  
Vis Spectroscopy

ABSTRACTThe emergence of multidrug-resistant bacteria is a global threat for human society. There exist recorded data that silver was used as an antimicrobial agent by the ancient Greeks and Romans during the 8th century. Silver nanoparticles (AgNPs) are of potential interest because of their effective antibacterial and antiviral activities, with minimal cytotoxic effects on the cells. However, very few reports have shown the usage of AgNPs for antibacterial therapyin vivo. In this study, we deciphered the importance of the chosen methods for synthesis and capping of AgNPs for their improved activityin vivo. The interaction of AgNPs with serum albumin has a significant effect on their antibacterial activity. It was observed that uncapped AgNPs exhibited no antibacterial activity in the presence of serum proteins, due to the interaction with bovine serum albumin (BSA), which was confirmed by UV-Vis spectroscopy. However, capped AgNPs [with citrate or poly(vinylpyrrolidone)] exhibited antibacterial properties due to minimized interactions with serum proteins. The damage in the bacterial membrane was assessed by flow cytometry, which also showed that only capped AgNPs exhibited antibacterial properties, even in the presence of BSA. In order to understand thein vivorelevance of the antibacterial activities of different AgNPs, a murine salmonellosis model was used. It was conclusively proved that AgNPs capped with citrate or PVP exhibited significant antibacterial activitiesin vivoagainstSalmonellainfection compared to uncapped AgNPs. These results clearly demonstrate the importance of capping agents and the synthesis method for AgNPs in their use as antimicrobial agents for therapeutic purposes.

scholarly journals In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Tan Dat Nguyen ◽  
Thanh Truc Nguyen ◽  
Khanh Loan Ly ◽  
Anh Hien Tran ◽  
Thi Thanh Ngoc Nguyen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Polyvinyl Alcohol ◽  
Healing Rate ◽  
Antibacterial Effects ◽  
Topical Gel ◽  
Significant Difference

Silver nanoparticles have attracted great interests widely in medicine due to its great characteristics of antibacterial activity. In this research, the antibacterial activity and biocompatibility of a topical gel synthesized from polyvinyl alcohol, chitosan, and silver nanoparticles were studied. Hydrogels with different concentrations of silver nanoparticles (15 ppm, 30 ppm, and 60 ppm) were evaluated to compare their antibacterial activity, nanoparticles’ sizes, and in vivo behaviors. The resulted silver nanoparticles in the hydrogel were characterized by TEM showing the nanoparticles’ sizes less than 22 nm. The in vitro results prove that the antibacterial effects of all of the samples are satisfied. However, the in vivo results demonstrate the significant difference among different hydrogels in wound healing, where hydrogel with 30 ppm shows the best healing rate.

scholarly journals Enhancement of the Antibacterial Activity of Silver Nanoparticles against Phytopathogenic BacteriumRalstonia solanacearumby Stabilization

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Juanni Chen ◽  
Shili Li ◽  
Jinxiang Luo ◽  
Rongsheng Wang ◽  
Wei Ding
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Synergistic Effects ◽  
Polyacrylamide Gel Electrophoresis ◽  
Sodium Dodecyl ◽  
Tween 80 ◽  
Phytopathogenic Bacterium ◽  
Crop Disease

In this paper, the enhanced antibacterial activity of silver nanoparticles (AgNPs) against the phytopathogenic bacteriumRalstonia solanacearumafter stabilization using selected surfactants (SDS, SDBS, TX-100, and Tween 80) was examined, in comparison with silver ion. Tween 80 was found to be the most preferable stabilizer of AgNPs due to the beneficial synergistic effects of the AgNPs and surfactant. However, all the surfactants nearly had no effects on the antibacterial activity of Ag+.In vitro, Tween 80-stabilized AgNPs showed the highest bactericidal activity againstR. solanacearum. Further measurements using TEM, fluorescence microscopy, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) revealed that though Ag+and Tween 80-Ag+induced high toxicity, Tween 80-stabilized AgNPs displayed most severe damage when in direct contact with cells, causing mechanistic injury to the cell membrane and strongly modifying and destructing the cellular proteins. Meanwhile,in vivo, the pot experiments data indicated that the control efficiency of Tween 80-stabilized AgNPs on tobacco bacterial wilt was 96.71%, 90.11%, and 84.21%, at 7 days, 14 days, and 21 days, respectively. Based on the results evidencing their advantageous low dosage requirements and strong antimicrobial activity, Tween 80-stabilized AgNPs are a promising antibacterial agent for use in alternative crop disease control approaches.

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