scholarly journals Worker Adaptation and Employer Accommodation Following the Onset of a Health Impairment

10.3386/w5169 ◽  
1995 ◽  
Author(s):  
Mary Daly ◽  
John Bound
Keyword(s):  
Health Impairment ◽  
Employer Accommodation

scholarly journals Health Impairment From Nasal Airway Obstruction and Changes in Health Utility Values From Septorhinoplasty

2019 ◽  
Vol 21 (2) ◽  
pp. 146-151
Author(s):  
Richard Tjahjono ◽  
Raquel Alvarado ◽  
Larry Kalish ◽  
Raymond Sacks ◽  
Raewyn Campbell ◽  
...  
Keyword(s):  
Airway Obstruction ◽  
Health Utility ◽  
Nasal Airway ◽  
Utility Values ◽  
Health Impairment

scholarly journals The Roles of MicroRNA-141 in Human Cancers: From Diagnosis to Treatment

2016 ◽  
Vol 38 (2) ◽  
pp. 427-448 ◽  
Author(s):  
Yanping Gao ◽  
Bing Feng ◽  
Siqi Han ◽  
Kai Zhang ◽  
Jing Chen ◽  
...  
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
Malignant Tumors ◽  
Untranslated Regions ◽  
Messenger Rnas ◽  
Gene Expressions ◽  
Mesenchymal Transition ◽  
Cellular Processes ◽  
Health Impairment ◽  
Non Coding Rnas ◽  
Human Malignant Tumors

Cancer remains one of the most threatening causes of human health impairment, and the mechanisms underlying tumorigenesis have not been completely characterized. MicroRNAs (miRNAs) are a group of endogenous, small (18∼25 nucleotides) non-coding RNAs which negatively regulate gene expressions by directly binding to the 3'-untranslated regions (3'-UTRs) of the target messenger RNAs (mRNAs). Increasing evidence has demonstrated abnormal miRNA profiles and confirmed their involvement in tumor initiation and progression. As one important member of the miR-200 family, microRNA (miR)-141 is aberrantly expressed in many human malignant tumors, participating in various cellular processes including epithelial-mesenchymal transition (EMT), proliferation, migration, invasion, and drug resistance. In the present review, we briefly describe the mechanisms underlying miR-141-mediated tumorigenesis and the possible future of miR-141 as a potential diagnostic and prognostic parameter as well as therapeutic target in clinical applications.

scholarly journals Merle phenotypes in dogs - SILV SINE insertions from Mc to Mh

2018 ◽  
Author(s):  
Langevin Mary ◽  
Helena Synkova ◽  
Tereza Jancuskova ◽  
Sona Pekova
Keyword(s):  
Coat Color ◽  
Study Group ◽  
Wild Type ◽  
Health Consequences ◽  
Breeding Programs ◽  
Health Impairment ◽  
Color Features ◽  
Coat Pattern ◽  
Type Sequence ◽  
Selection Of

ABSTRACTIt has been recognized that the Merle coat pattern is not only a visually interesting feature, but it also exerts an important biological role, in terms of hearing and vision impairments. In 2006, the Merle (M) locus was mapped to the SILV gene with a SINE element in it, and the inserted retroelement was proven causative to the Merle phenotype. Mapping of the M locus was a genetic breakthrough and many breeders started implementing SILV SINE testing in their breeding programs. Unfortunately, the situation turned out complicated as genotypes of Merle tested individuals did not always correspond to expected phenotypes, sometimes with undesired health consequences in offspring. Two variants of SILV SINE, allelic to the wild type sequence, have been described so far - Mc and M.Here we report a significantly larger portfolio of existing Merle alleles (Mc, Mc+, Ma, Ma+, M, Mh) in Merle dogs, which are associated with unique coat color features and stratified health impairment risk. The refinement of allelic identification was made possible by systematic, detailed observation of Merle phenotypes in a cohort of 181 dogs from known Merle breeds, by many breeders worldwide, and the use of advanced molecular technology enabling the discrimination of individual Merle alleles with significantly higher precision than previously available.We also show that mosaicism of Merle alleles is an unexpectedly frequent phenomenon, which was identified in 30 out of 181 (16.6%). dogs in our study group. Importantly, not only major alleles, but also minor Merle alleles can be inherited by the offspring. Thus, mosaic findings cannot be neglected and must be reported to the breeder in their whole extent.In light of negative health consequences that may be attributed to certain Merle breeding strategies, we strongly advocate implementation of the refined Merle allele testing for all dogs of Merle breeds to help the breeders in selection of suitable mating partners and production of healthy offspring.

Other Health Impairment (OHI) Disabilities Category and an In-Depth Look at the Most Common Neurobiological Condition for Students

2022 ◽  
pp. 55-68
Author(s):  
Tammy Reutzel Guthrie
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Kidney Disease ◽  
General Education ◽  
Sickle Cell Anemia ◽  
Health Problem ◽  
Educational Environment ◽  
The Other ◽  
Health Impairment ◽  
Hyperactivity Disorder ◽  
Other Health Impairment

The other health impairment (OHI) disability category refers to a condition that causes limited strength, vitality, or alertness, including heightened alertness to environmental stimuli that results in limited alertness with respect to the educational environment due to a chronic or acute health problem and adversely affects a child's educational performance. This disability category, as explored in this chapter, may include one or a combined type of attention-deficit hyperactivity disorder, asthma, diabetes, epilepsy, a heart condition, kidney disease, sickle cell anemia, and Tourette's syndrome. As a result of the child's other health impairment, as described above, the child is prevented from receiving reasonable educational benefit from general education.

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