scholarly journals Formulasi Sediaan Salep Esktrak Etanol Daun Sirsak (Anonna mucirata L.) Dengan Variasi Basis Salep

2020 ◽  
Vol 5 (3) ◽  
pp. 106
Author(s):  
Indian Cahyani ◽  
Aulia D. Pelu ◽  
Jayanti Djarami ◽  
Epi Dusra
Keyword(s):  
Physical Properties ◽  
Traditional Medicine ◽  
Dosage Form ◽  
Ethanol Extract ◽  
Water Soluble ◽  
Homogeneity Test ◽  
Organoleptic Test ◽  
Ointment Base ◽  
Ointment Formulation ◽  
Soluble Base

The use of natural ingredients as traditional medicine with better use is now more in demand. This is because traditional medicine is relatively easy to obtain. One type of medicinal plant that is often used by the community is (Annona mucirata L). or better known as soursop. Soursop leaves (Anonna mucirata L.) have been widely used as a medicinal ingredient because it contains tannin and flavanoid compounds which can provide antibacterial effects. The purpose of this study was to determine the content of the compounds contained in soursop leaves (Anonna mucirata L.) and to formulate an ethanol extract ointment of soursop leaves (Anonna mucirata L.) with various ointment bases. This research was conducted using an experimental method in which evaluations of the ointment were carried out including the organoleptic test, pH test and homogeneity test. The results showed that ethanol extract of soursop leaves (Anonna mucirata L.) containing tannins and flavonoids. The results of the ointment formulation on the hydrocarbon base formulation, the absorption base formulation and the water soluble base formulation resulted in physical differences in the organoleptic test, but did not have different results on the homogeneity test and pH test. In conclusion, extract ethanol of soursop (Anonna mucirata L.) leaf contains tannin and flavanoid compounds. The ethanol extract ointment of soursop leaves (Anonna mucirata L.) with variations of FI (hydrocarbon base) and FII (absorption base) ointment has good ointment properties, while FIII (water-soluble base) does not have good physical properties because it has a dosage form which is liquid and smells rancid based on the organoleptic test. The ethanol extract ointment of soursop leaves (Anonna mucirata L.) with variations of FI (hydrocarbon base) and FII (absorption base) ointment has good ointment properties, while FIII (water-soluble base) does not have good physical properties because it has a liquid dosage form and smells rancid based on the organoleptic test. Keywords: ointment extract; soursop plant; ointment base ABSTRAK Pemanfaatan bahan alam sebagai obat tradisional dengan penggunaan yang lebih baik sekarang lebih diminati. Hal ini dikarenkan obat tradisional relatif mudah didapat. Salah satu jenis tanaman obat yang sering dimanfaatkan oleh masyarakat adalah (Annona mucirata L). atau yang lebih di kenal dengan nama sirsak. Tanaman daun sirsak (Anonna mucirata L.) sudah banyak digunakan sebagai bahan obat karena mengandung senyawa tannin dan flavanoid yang mampu memberikan efek antibakteri. Tujuan penelitian ini untuk mengetahui kandungan senyawa yang terdapat pada daun sirsak (Anonna mucirata L.) serta membuat formulasi sediaan salep esktrak etanol daun sirsak (Anonna mucirata L.) dengan variasi basis salep. Penelitian ini dilakukan dengan menggunakan metode experimental dimana dilakukan evaluasi terhadap salep yang dibuat meliputi uji organoleptik, uji pH dan uji homogenitas. Hasil penelitian ini yaitu ekstrak etanol daun sirsak (Anonna mucirata L.) mengandung senyawa tannin dan flavanoid, untuk hasil formulasi sediaan salep pada formulasi basis hidrokarbon, formulasi basis absorbsi dan formulasi basis larut air menghasilkan perbedaan fisik uji organoleptik, namun tidak memiliki hasil yang berbeda pada uji homogenitas dan uji pH. Dari hasil penelitian dapat disimpulkan yaitu ekstrak estanol daun sirsak (Anonna mucirata L.) mengandung senyawa tannin dan flavanoid. Sediaan salep esktrak etanol daun sirsak (Anonna mucirata L.) dengan variasi basis salep FI (basis hidrokarbon) dan FII (basis absorbsi) memiliki sifat salep yang baik, sedangkan FIII (basis larut air) tidak memiliki sifak fisik yang baik karena memiliki bentuk sediaan yang cair dan bau tengik berdasarkan uji organoleptik. Kata kunci: ekstrak salep; tanaman daun sirsak; basis salep

scholarly journals Uji Daya Hambat Formulasi Salep Ekstrak Etanol Umbi Hati Tanah (Angiopteris sp) terhadap Bakteri Staphylococcus aureus

2018 ◽  
Vol 5 (2) ◽  
pp. 119-125
Author(s):  
Rezqi Handayani ◽  
Nurul Qamariah
Keyword(s):  
Staphylococcus Aureus ◽  
Ethanol Extract ◽  
Water Soluble ◽  
Test Material ◽  
Positive Bacterium ◽  
Plant Extraction ◽  
Ointment Formulation ◽  
Primary Test ◽  
Soluble Base ◽  
Active Substances

Hati Tanah tuber (Angiopteris sp) is a plant part that is often used by Dayak tribes in Central Kalimantan as a medicine to heal wounds. This plant is known to contain flavonoid, saponin, tannin and catechol compounds which in previous studies have proven that ethanol extract of this plant can inhibit the growth of Staphylococcus aureus bacteria. Staphylococcus aureus is a Gram-positive bacterium that causes infection in wounds. Some of these strains of bacteria are resistant to available antibiotics. In this study two bases of ointment were used, namely, the bottom of the hydrocarbon ointment and the base of the water-soluble lotion. This study aims to determine the ointment formulation which can inhibit the growth of S. aureus bacteria. Plant extraction is done by the soxhletation method. The inhibitory test in this study uses a process of planting discs that contain active substances as the primary test material. The results showed that the base ointment formulation which could inhibit the growth of Staphylococcus aureus bacteria was an ointment formulation with a water-soluble base.

scholarly journals Ointment Formulation and Test Safety from Sapodilla Manila Leaf Extract (Manilkara zapota L.) with Variation of Ointment Base as an Ulcer Medicine

2020 ◽  
Vol 2 (1) ◽  
pp. 14
Author(s):  
Imas Maesaroh ◽  
Daniar Pratiwi ◽  
Leli Agustin
Keyword(s):  
Staphylococcus Aureus ◽  
Leaf Extract ◽  
Physical Characteristics ◽  
Water Soluble ◽  
Manilkara Zapota ◽  
Ointment Base ◽  
Different Types ◽  
Ointment Formulation ◽  
Soluble Base ◽  
Active Substances

Leaf extract of Manilkara zapota L has antibacterial activity against Staphylococcus aureus at a  base on potency test of 50%, where the bacteria are the cause of boils. Some of effort to facilitate the use and increase the activity of active substances, then ointments are prepared on a variety of ointment bases. This study aims to prepared Manilkara zapota L leaf extract into ointment formulations, and chosed the best of ointment base formulations that meets the requirements standards for good ointment preparations. The extract was obtained by maceration using ethanol 96%. Ointments are formulated with four different types of ointment bases, which are hydrocarbon base, absorbing base, water removed bases, and water soluble base. The ointment that has been produced is tested for the physical characteristics such as organoleptic test, homogeneity, pH, spreadibility, adhesion, and viscosity had been tested on manufactured ointments. The results of this study indicate that leaf extract of Manilkara zapota L can be formulated into ointment preparations, variations in the ointment base affect the physical characteristics of ointment preparations.Keywords: Ointment, Manilkara zapota L Leaf, Antibacterial, Staphylococcus aureus

REVIEW : KARAKTERISTIK FISIK DAN DAYA IRITASI MINYAK ATSIRI BUNGA CENGKEH (Syzygium aromaticum) DALAM BEBERAPA TIPE BASIS SEBAGAI ANTI-INFLAMASI

2020 ◽  
Vol 5 (2) ◽  
pp. 364-375
Author(s):  
Amraini Amelia ◽  
◽  
Nining Sugihartini ◽  
Hari Susanti ◽  
Keyword(s):  
Essential Oil ◽  
Physical Properties ◽  
Research Method ◽  
Water Soluble ◽  
Syzygium Aromaticum ◽  
Absorption Properties ◽  
Inflammatory Drugs ◽  
Clove Essential Oil ◽  
Soluble Base ◽  
Essential Oil Formulations

This review aims to determine the types of bases that can be used every day, which are effective and efficient as anti-inflammatory drugs. The research method used was to review the development of clove essential oil formulations that have been carried out using various concentrations of various types of bases including M / A type cream, A / M type cream, water soluble base, lotion, emulgel, hydrocarbons, hydrogels and absorbents. The recommended formulation is type M / A cream with a concentration of 5% clove flower essential oil. The types of bases studied were M / A cream, type A / M cream, water soluble base, lotion, emulgel, hydrocarbons, hydrogels and absorption properties which had good physical properties and did not irritate the skin of the test animals. This review refers to several national and international journals released in the last ten years, from 2010 to 2020.

scholarly journals Uji efektivitas gel ekstrak etanol daun kelor (Moringa oleifera L.) sebagai antijamur Malassezia furfur

2018 ◽  
Vol 5 (2) ◽  
pp. 62
Author(s):  
Anna L Yusuf ◽  
Ecin Nurawaliah ◽  
Nurhidayati Harun
Keyword(s):  
Antifungal Activity ◽  
Physical Properties ◽  
Moringa Oleifera ◽  
Methyl Cellulose ◽  
Ethanol Extract ◽  
Diffusion Method ◽  
Measured Parameter ◽  
Malassezia Furfur ◽  
Organoleptic Test ◽  
Solid Diffusion

<p align="center"><strong>Abstrak</strong></p><p align="center"><strong> </strong></p><p>Kandungan daun kelor (<em>Moringa oleifera</em> L) diketahui dapat berkhasiat sebagai antijamur. Penelitian ini bertujuan untuk memformulasi dan mengetahui aktivitas antijamur gel yang mengandung daun kelor terhadap jamur <em>Malasezia furfur</em>. Ekstraksi daun kelor dilakukan menggunakan etanol 70% dengan metode maserasi. Formulasi gel yang mengandung ekstrak etanol daun kelor dilakukan menggunakan hidroksi propil metil selulosa (HPMC) dengan berbagai konsentrasi, yaitu 2, 3, dan 4%., Evaluasi gel yang dilakukan adalah uji organoleptik, homogenitas, pH, daya sebar, daya lekat, dan viskositas. Kemudian dilakukan uji aktivitas antijamur dengan menggunakan metode difusi padat dengan kertas cakram, dan digunakan gel ketokonazol sebagai pembanding. Parameter yang diukur adalah zona hambat antijamur. Hasil kemudian dianalisis statistik <em>Kruskall Wallis</em> dan <em>Mann Withney</em>. Berdasarkan evaluasi gel, diperoleh bahwa peningkatan  konsentrasi basis HPMC 2, 3, dan 4% dalam sediaan gel  ekstrak etanol daun kelor dapat meningkatkan viskositas gel, daya lekat gel, menyebabkan penurunan daya sebar gel, dan mempengaruhi peningkatan konsistensi sediaan gelpada uji organoleptik tanpa mempengaruhi uji pH gel dan homogenitas gel. Formula yang memiliki sifat fisik gel yang yang baik jika dilihat dari hasil  uji sifat fisik gel yang meliputi uji organoleptik,homogenitas, pH, daya sebar daya lekat dan viskositas   yaitu formula  gel ekstrak etanol daun kelor dengan konsentrasi basis HPMC 2 % karena hampir dari semua uji memenuhi persyaratan literatur. Dari penelitian ini dapat disimpulkan  gel ekstrak etanol daun kelor mempunyai aktivitas antijamur <em>M.furfur</em> dan gel yang mengandung HPMC 2% memiliki sifat fisik gel dan aktivitas antijamur lebih baik jika dibandingkan dengan gel konsentrasi HPMC 3 dan 4%.</p><p> </p><p><strong>Kata Kunci:</strong> Daun Kelor, <em>Moringa </em><em>o</em><em>leifera L,</em> gel, antijamur, <em>Malassezia </em><em>f</em><em>urfur.</em></p><p><em> </em></p><p><em> </em></p><p align="center"><strong><em>The effectiveness test of gel of ethanol extract of Moringa oleifera leaves <br /> as antifungal of </em></strong><strong><em>Malassezia furfur</em></strong></p><p align="center"><strong><em> </em></strong></p><p align="center"><strong><em>Abstract</em></strong><strong><em></em></strong></p><p><strong><em> </em></strong></p><p><em>Moringa leaf content (Moringa oleifera L) is known to be efficacious as an antifungal. The aim of this research is to formulate and to know gel antifungal activity containing moringa leaf against Malasezia furfur fungus. Moringa leaf extraction was done using 70% ethanol by maceration method. The gel formulation containing ethanol extract of </em><em>moringa </em><em>was conducted using hydroxy propyl methyl cellulose (HPMC) with various concentrations, ie 2, 3, and 4%. Evaluation of gel performed was organoleptic, homogeneity, pH, spreading, </em><em>and </em><em>viscosity. Then the antifungal activity </em><em>was </em><em>tested using solid diffusion method with paper disc, and used ketoconazole gel as comparison. The measured parameter </em><em>wa</em><em>s the antifungal block zone. The results were then analyzed statistically </em><em>using </em><em>Kruskall Wallis and Mann Withney. Based on the gel evaluation, it was found that the increased concentrations of HPMC 2, 3, and 4% base concentrations in the gel preparation of ethanol extract of moringa leaf can increase gel viscosity, gel adhesiveness, decrease the gel power, and influence the consistency of preparation for organoleptic test without affecting the test pH gel and gel homogeneity. Formula which have good physical properties of gel when viewed from the test results of physical properties of gel which include organoleptic test, homogeneity, pH, viscosity sticky power and viscosity is gel gel ethanol extract leaf kelor with 2% HPMC base concentration because almost of all test meet the literature requirements. From this study, it can be concluded that leaf extract gel ethanol gel has antifungal activity of M.furfur and gel containing HPMC 2% has gel physical properties and antifungal activity is better when compared with HPMC 3 and 4% concentration gel</em><em></em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em>: </em><em> </em><em>Moringa olifera L.,</em><em>gel, </em><em> antifungal</em><em>, </em><em>Malasezia furfur</em><em></em></p>

scholarly journals OPTIMASI KONSENTRASI POLIVINIL PIROLIDON (PVP) SEBAGAI BAHAN PENGIKAT TEHADAP SIFAT FISIK TABLET EKSTRAK ETANOL RIMPANG BANGLE (Zingiber cassumunar Roxb)

2018 ◽  
pp. 45
Author(s):  
Ida ayu Sintha Devi
Keyword(s):  
Physical Properties ◽  
Bitter Taste ◽  
Ethanol Extract ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Organoleptic Test ◽  
Size Uniformity ◽  
The Right ◽  
Test Requirements ◽  
Zingiber Cassumunar

Zingiber cassumunar Roxb contains active compounds such as cassumumin AC, cassummarin AC, phenylbutanoid, and (E) -4- (3,4-dimethoxyphenyl) but-3-en-1-ol which has activities as anti-inflammatory, antioxidant and anti-allergenic agents so that they are potentially used as anti-allergies. Zingiber cassumunar Roxb is made into tablet because it has several advantages, which are easy to consume, practical, the right amount, cover the bitter taste and the distinctive smell and its stability is maintained in storage. This study aims to produce Zingiber cassumunar Roxb tablets that have good physical properties by using PVP as a binder. Zingiber cassumunar Roxb extract was made by maceration using 70% ethanol solvent, the tablet was formulated using wet granulation method. Zingiber cassumunar Roxb ethanol extract tablet was formulated in 3 formulas with variations in the PVP FI content of 1%, FII 2.75%, and FIII 4.5%. The resulting granules were tested for physical properties including moisture test, particle size distribution, flow time, stationary angle, bulk density, and compressibility, while the tablets produced were tested for physical properties including organoleptic test, uniformity of size, uniformity of weight, friability, and disintegration time. The results showed that the optimum concentration obtained was at FIII with 4.5% PVP concentration that complied the organoleptic test requirements, uniformity of size, weight uniformity, and fragility of tablets.

UJI DAYA HAMBAT ANTIBAKTERI SALEP EKSTRAK ETANOL DAUN PANDAN HUTAN (Freycinetia sessiliflora Rizki.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus epidermidis

2020 ◽  
Vol 5 (2) ◽  
pp. 376-386
Author(s):  
Fitri Sri Rizki ◽  
◽  
Ade Ferdinan
Keyword(s):  
Secondary Metabolites ◽  
Staphylococcus Epidermidis ◽  
Ethanol Extract ◽  
Average Diameter ◽  
Inhibitory Effect ◽  
Water Soluble ◽  
Diffusion Method ◽  
Disk Diffusion Method ◽  
Bacteria Inhibition ◽  
Soluble Base

Freycinetia sessiliflora Rizki is a plant that has secondary metabolites, namely alkaloids, flavonoids, terpenoids-steroids, saponins, phenols and tannins. This study aims to determine whether there is inhibitory and concentrated ointment extract of thick pandanus leaf of the forest that can inhibit the growth of Stapylococcus epidermidis bacteria. Inhibition testing was carried out by disk diffusion method with different concentrations of 5% and 10% concentrations made 9 ointment formulas with a variety of 3 bases namely hydrocarbon base, absorbency base and water soluble base. The results of inhibitory measurements of ethanol extract ointment leaves of pandanus leaves are good or have the greatest value to the smallest inhibitory effect on the growth of Staphylococcus epidermidis bacteria with an average diameter of inhibition at F6 of 4.11 mm, F1 of 2.78 mm, F3 of 2.68 mm, F5 of 2.47 mm, F4 of 2.25 mm, F2 of 2.23 mm, F7 of 1.29, F8 of 1.13 and F9 of 0.86 mm.

scholarly journals FORMULATION OF OINTMENT OF ANTIBACTERY ETHANOL EXTRACT OF TORCH GINGER (Etlingera elatior) AGAINST BACTERIA Staphylococcus aureus

2018 ◽  
Vol 1 (1) ◽  
pp. 1-5
Author(s):  
Ainil Fithri Pulungan ◽  
Debi Dinha Octora Sitepu ◽  
Devi Mariana Sinaga
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Physical Stability ◽  
Ethanol Extract ◽  
Diffusion Method ◽  
Ointment Base ◽  
Ointment Formulation ◽  
Inhibitory Power ◽  
Made In ◽  
Etlingera Elatior

One of the causes of infection was bacteria, such as Staphylococcus aureus. Torch ginger has been widely used to treat dwaseases caused by bacteria. Torch ginger has been studied to have antibacterial activity against Staphylococcus aureus bacteria. The purpose of thwas study was to formulate an ointment preparation of ethanol extract of torch ginger and to see if the ointment preparations had antibacterial activity against Staphylococcus aureus bacteria. The research method used in thwas research was experimental True, covering the stages: making of ethanol extract of kecombrang flower with maceration method using 96% ethanol solvent, ointment formulation made with ointment base: vaseline, adeps lanae, and propylene glycol. Made in three concentrations of extracts namely: F I with 100 mg, F II with 200 mg, and F III with 300 mg. Furthermore, the evaluation of the preparation of evaluation of physical stability and homogeneity, and test of antibacterial activity against Staphylococcus aureus bacteria with diffusion method to use Kirby odor dwasc paper. The results showed that the ointment had good physical stability and homogeneity for 30 days of storage at room temperature. The antibacterial activity test of the ointment shows that the inhibitory diameter F I has an average of 16.45 mm, F II has an average of 18.60 mm and F III has an average of 21.12 mm. Based on the results obtained it can be concluded that the preparation of the ethanol extract of torch ginger has an inhibitory power to Staphylococcus aureus bacteria. In the next research was expected to pay attention to the growing area of ​​torch ginger  and to compare the antibacterial activity between petal flowers and flower seeds using Staphylococcus aureus bacteria.

scholarly journals UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN KRIM EKSTRAK ETANOL DAUN KEMANGI (Ocimum basilicum L.) TERHADAP Staphylococcus aureus

PHARMACON ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 661
Author(s):  
Axcel H. Tondolambung ◽  
Hosea Jaya Edy ◽  
Julianri S. Lebang
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Dosage Form ◽  
Ph Value ◽  
Ethanol Extract ◽  
Average Diameter ◽  
Ocimum Basilicum ◽  
Homogeneity Test ◽  
Average Value ◽  
Dispersion Test

ABSTRACT Basil leaves (Ocimum basilicum  L.) contain flavonoid, saponins and tannins that have antibacterial activity. This study is aims to make basil cream then determine antibacterial activity of cream against Staphylococcus aureus. The cream  was made with five concentrations of extract 3%, 6%, 9%, 12%, 15% respectively. The extract was obtained by maceration using 96% ethanol solvent. Antibacterial test was carried out by using the well method. The results of the evaluation of physical properties for the organoleptic test and homogeneity test showed that the cream dosage form met the requirements, the average pH value is 4.92±0.27, average value of dispersion test is 3.30±0.0 cm, average value of adhesion test is 7.92±0.29 seconds. Antibacterial effectiveness test showed an average diameter value for formula I (3%) is 8.94±1.60 mm, formula II (6%) 9.46±6.85 mm, formula III (9%) 10.30±3.28 mm, formula IV (12%) 15.18±8.04 mm, formula V(15%) 16.23±4.16 mm. The statistical test proves that formula V has the best resistance  and can be concluded that the antibacterial cream dosage form of the ethanol extract of basil leaves can be formulated into a cream that is good, physically stable and can inhibit bacterial growth. Keywords: Basil Leaves (Ocimum basilicum  L.), Cream, Antibacterial. ABSTRAK Daun Kemangi (Ocimum basilicum  L.) memiliki kandungan senyawa flavonoid, saponin dan tannin yang bersifat sebagai antibakteri. Penelitian ini bertujuan untuk membuat sediaan krim ekstrak etanol daun kemangi yang stabil secara fisik dan mengetahui daya hambat krim antibakteri terhadap bakteri Staphylococcus aureus. Krim dibuat menggunakan lima variasi konsentrasi ekstrak yaitu 3%, 6%, 9%, 12%, 15%. Ekstrak diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Uji antibakteri dilakukan dengan metode sumuran. Hasil evaluasi sifat fisik untuk uji organoleptik dan uji homogenitas menunjukkan sediaan krim memenuhi persyaratan, nilai pH rata-rata 4,92±0,27 nilai rata-rata daya sebar 3,30±0,0 cm; niai rata-rata uji daya lekat 7,92±0,29 detik. Uji efektivitas antibakteri menunjukkan nilai rata-rata diameter untuk formula I (3%); 8,94±1,60 mm; formula II (6%) 9,46±6,85 mm; formula III (9%) 10,30±3,28 mm; formula IV (12%) 15,18±8,04 mm; dan formula V (15%) 16,23±4,16 mm. Uji statistika membuktikan bahwa formula V memiliki daya hambat yang paling baik dan disimpulkan bahwa ekstrak etanol daun kemangi dapat diformulasikan menjadi sediaan krim yang baik dan stabil secara fisik dan dapat menghambat pertumbuhan bakteri. Kata Kunci: Daun Kemangi (Ocimum basilicum  L.) , Krim, Antibakteri

scholarly journals Uji efektivitas gel ekstrak etanol daun kelor (Moringa oleifera L.) sebagai antijamur Malassezia furfur

2017 ◽  
Vol 5 (2) ◽  
pp. 62
Author(s):  
Anna L Yusuf ◽  
Ecin Nurawaliah ◽  
Nurhidayati Harun
Keyword(s):  
Antifungal Activity ◽  
Physical Properties ◽  
Moringa Oleifera ◽  
Methyl Cellulose ◽  
Ethanol Extract ◽  
Diffusion Method ◽  
Measured Parameter ◽  
Malassezia Furfur ◽  
Organoleptic Test ◽  
Solid Diffusion

<p align="center"><strong>Abstrak</strong></p><p align="center"><strong> </strong></p><p>Kandungan daun kelor (<em>Moringa oleifera</em> L) diketahui dapat berkhasiat sebagai antijamur. Penelitian ini bertujuan untuk memformulasi dan mengetahui aktivitas antijamur gel yang mengandung daun kelor terhadap jamur <em>Malasezia furfur</em>. Ekstraksi daun kelor dilakukan menggunakan etanol 70% dengan metode maserasi. Formulasi gel yang mengandung ekstrak etanol daun kelor dilakukan menggunakan hidroksi propil metil selulosa (HPMC) dengan berbagai konsentrasi, yaitu 2, 3, dan 4%., Evaluasi gel yang dilakukan adalah uji organoleptik, homogenitas, pH, daya sebar, daya lekat, dan viskositas. Kemudian dilakukan uji aktivitas antijamur dengan menggunakan metode difusi padat dengan kertas cakram, dan digunakan gel ketokonazol sebagai pembanding. Parameter yang diukur adalah zona hambat antijamur. Hasil kemudian dianalisis statistik <em>Kruskall Wallis</em> dan <em>Mann Withney</em>. Berdasarkan evaluasi gel, diperoleh bahwa peningkatan  konsentrasi basis HPMC 2, 3, dan 4% dalam sediaan gel  ekstrak etanol daun kelor dapat meningkatkan viskositas gel, daya lekat gel, menyebabkan penurunan daya sebar gel, dan mempengaruhi peningkatan konsistensi sediaan gelpada uji organoleptik tanpa mempengaruhi uji pH gel dan homogenitas gel. Formula yang memiliki sifat fisik gel yang yang baik jika dilihat dari hasil  uji sifat fisik gel yang meliputi uji organoleptik,homogenitas, pH, daya sebar daya lekat dan viskositas   yaitu formula  gel ekstrak etanol daun kelor dengan konsentrasi basis HPMC 2 % karena hampir dari semua uji memenuhi persyaratan literatur. Dari penelitian ini dapat disimpulkan  gel ekstrak etanol daun kelor mempunyai aktivitas antijamur <em>M.furfur</em> dan gel yang mengandung HPMC 2% memiliki sifat fisik gel dan aktivitas antijamur lebih baik jika dibandingkan dengan gel konsentrasi HPMC 3 dan 4%.</p><p> </p><p><strong>Kata Kunci:</strong> Daun Kelor, <em>Moringa </em><em>o</em><em>leifera L,</em> gel, antijamur, <em>Malassezia </em><em>f</em><em>urfur.</em></p><p><em> </em></p><p><em> </em></p><p align="center"><strong><em>The effectiveness test of gel of ethanol extract of Moringa oleifera leaves <br /> as antifungal of </em></strong><strong><em>Malassezia furfur</em></strong></p><p align="center"><strong><em> </em></strong></p><p align="center"><strong><em>Abstract</em></strong><strong><em></em></strong></p><p><strong><em> </em></strong></p><p><em>Moringa leaf content (Moringa oleifera L) is known to be efficacious as an antifungal. The aim of this research is to formulate and to know gel antifungal activity containing moringa leaf against Malasezia furfur fungus. Moringa leaf extraction was done using 70% ethanol by maceration method. The gel formulation containing ethanol extract of </em><em>moringa </em><em>was conducted using hydroxy propyl methyl cellulose (HPMC) with various concentrations, ie 2, 3, and 4%. Evaluation of gel performed was organoleptic, homogeneity, pH, spreading, </em><em>and </em><em>viscosity. Then the antifungal activity </em><em>was </em><em>tested using solid diffusion method with paper disc, and used ketoconazole gel as comparison. The measured parameter </em><em>wa</em><em>s the antifungal block zone. The results were then analyzed statistically </em><em>using </em><em>Kruskall Wallis and Mann Withney. Based on the gel evaluation, it was found that the increased concentrations of HPMC 2, 3, and 4% base concentrations in the gel preparation of ethanol extract of moringa leaf can increase gel viscosity, gel adhesiveness, decrease the gel power, and influence the consistency of preparation for organoleptic test without affecting the test pH gel and gel homogeneity. Formula which have good physical properties of gel when viewed from the test results of physical properties of gel which include organoleptic test, homogeneity, pH, viscosity sticky power and viscosity is gel gel ethanol extract leaf kelor with 2% HPMC base concentration because almost of all test meet the literature requirements. From this study, it can be concluded that leaf extract gel ethanol gel has antifungal activity of M.furfur and gel containing HPMC 2% has gel physical properties and antifungal activity is better when compared with HPMC 3 and 4% concentration gel</em><em></em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em>: </em><em> </em><em>Moringa olifera L.,</em><em>gel, </em><em> antifungal</em><em>, </em><em>Malasezia furfur</em><em></em></p>

STUDY ON PHYSICAL AND SENSORICAL CHARACTERISTICS OF FLESH RESTRUCTURED WITH SAGO CATFISH JERKY

2014 ◽  
Vol 4 (2) ◽  
pp. 55-64
Author(s):  
Amir Jayani ◽  
Zulman Efendi ◽  
Devi Silsia
Keyword(s):  
Physical Properties ◽  
Water Content ◽  
Analysis Of Variance ◽  
Test Data ◽  
Organoleptic Test ◽  
Significant Difference

This study aims to gain influence the thickness and concentration variations affect the characteristics of sago binder physical properties of catfish jerky. As well as getting influence the thickness and concentration variations affect the level of binder sago joy panelists in terms of organoleptic test. Data were analyzed by analysis of variance using the Analysis Of Variance (ANOVA). If there is a significant difference followed by a further test of DMRT 5% level (physical properties). While the hedonic test performed using Kruskal Wallis analysis. Results uniformity analysis (ANOVA) showed catfish fillet thickness and concentration of sago affect the physical properties of the water content and the level of violence. Where catfish jerky using sago binder 5% and 10% significantly different. The use of sago binder 5% and 10% led to an increase in water content. Besides the addition of the binder resulted in increasing levels of violence catfish jerky. Based on the statistics found that the influence of the thickness and concentration of the binder sago aroma, flavor and color of the sixth jerky catfish were not significantly different. But the texture was significantly different.

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