scholarly journals OMSimulator - Integrated FMI and TLM-based Co-simulation with Composite Model Editing and SSP

2019 ◽  
Author(s):  
Lennart Ochel ◽  
Robert Braun ◽  
Bernhard Thiele ◽  
Adeel Asghar ◽  
Lena Buffoni ◽  
...  
Keyword(s):  
Composite Model ◽  
Model Editing

Multilocus Analysis of Genetic Susceptibility to Myocardial Infarction in Russians: Replication Study

Acta Naturae ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 74-83
Author(s):  
N. G. Kukava ◽  
B. V. Titov ◽  
G. J. Osmak ◽  
N. A. Matveeva ◽  
O. G. Kulakova ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Genetic Markers ◽  
Prognostic Significance ◽  
Cumulative Effect ◽  
Mthfr Gene ◽  
Composite Model ◽  
Replication Study ◽  
Epistatic Interactions ◽  
Multilocus Analysis ◽  
Lipid Metabolism Genes

In search of genetic markers of myocardial infarction (MI) risk, which have prognostic significance for Russians, we performed a replication study of MI association with genetic variants of PCSK9 (rs562556), APOE (epsilon polymorphism, rs7412 and rs429358), LPL (rs320), MTHFR (rs1801133), eNOS (rs2070744), and the 9p21 region (rs1333049) in 405 patients with MI and 198 controls. Significant MI association was observed with variants of the lipid metabolism genes (PCSK9, APOE and LPL), and of eNOS. The SNPs in the MTHFR gene and the 9p21 region were not significantly associated with MI one by one but were included in several different MI-associated allelic combinations identified by multilocus analysis. Since we have not revealed nonlinear epistatic interactions between the components of the identified combinations, we postulate that the cumulative effect of genes that form a combination arises from the summation of their small independent contributions. The prognostic significance of the additive composite model built from the PCSK9, APOE, LPL, and eNOS genes as genetic markers was assessed using ROC analysis. After we included these markers in the previously published composite model of individual genetic risk of MI, the prognostic efficacy in our sample reached AUC = 0.676. However, the results obtained in this study certainly need to be replicated in an independent sample of Russians.

A Reinvestigation of the Deceptively Simple Reaction of Toluene with ●OH, and the Fate of the Benzyl Radical. I. a Combined Thermodynamic and Kinetic Study on the Competition Between ●OH Addition and Hydrogen Abstraction Reactions.

2019 ◽  
Author(s):  
Zoi Salta ◽  
Agnie M. Kosmas ◽  
Marc E. Segovia ◽  
Martina Kieninger ◽  
Oscar Ventura ◽  
...  
Keyword(s):  
Density Functional ◽  
Room Temperature ◽  
Hydrogen Abstraction ◽  
Reaction Rates ◽  
Composite Model ◽  
Alternative Mechanism ◽  
Radical Intermediate ◽  
Experimental Conditions ◽  
Methyl Group ◽  
Benzyl Radical

This work reports density functional and composite model chemistry calculations performed on the reactions of toluene with the hydroxyl radical. Both experimentally observed H-abstraction from the methyl group and possible additions to the phenyl ring were investigated. Reaction enthalpies and heights of the barriers suggest that H-abstraction is more favorable than ●OH addition to the ring. The calculated reaction rates at room temperature and the radical-intermediate product fractions support this view. This is somehow contradictory with the fact that, under most experimental conditions, cresols are observed in a larger concentration than benzaldehyde. Since the accepted mechanism for benzaldehyde formation involves H-abstraction, a contradiction arises that begs for an explanation. In this first part of our work we give the evidences that support the preference of hydrogen abstraction over ●OH addition and suggest an alternative mechanism which shows that cresols can actually arise also from the former reaction and not only from the latter.

A Reinvestigation of the Deceptively Simple Reaction of Toluene with ●OH, and the Fate of the Benzyl Radical. I. a Combined Thermodynamic and Kinetic Study on the Competition Between ●OH Addition and Hydrogen Abstraction Reactions.

2019 ◽  
Author(s):  
Zoi Salta ◽  
Agnie M. Kosmas ◽  
Marc E. Segovia ◽  
Martina Kieninger ◽  
Oscar Ventura ◽  
...  
Keyword(s):  
Density Functional ◽  
Room Temperature ◽  
Hydrogen Abstraction ◽  
Reaction Rates ◽  
Composite Model ◽  
Alternative Mechanism ◽  
Radical Intermediate ◽  
Experimental Conditions ◽  
Methyl Group ◽  
Benzyl Radical

This work reports density functional and composite model chemistry calculations performed on the reactions of toluene with the hydroxyl radical. Both experimentally observed H-abstraction from the methyl group and possible additions to the phenyl ring were investigated. Reaction enthalpies and heights of the barriers suggest that H-abstraction is more favorable than ●OH addition to the ring. The calculated reaction rates at room temperature and the radical-intermediate product fractions support this view. This is somehow contradictory with the fact that, under most experimental conditions, cresols are observed in a larger concentration than benzaldehyde. Since the accepted mechanism for benzaldehyde formation involves H-abstraction, a contradiction arises that begs for an explanation. In this first part of our work we give the evidences that support the preference of hydrogen abstraction over ●OH addition and suggest an alternative mechanism which shows that cresols can actually arise also from the former reaction and not only from the latter.

scholarly journals COLOR SUPERCONDUCTIVITY FROM SUPERSYMMETRY

2005 ◽  
Vol 20 (20) ◽  
pp. 1495-1502 ◽  
Author(s):  
NOBUHITO MARU ◽  
MOTOI TACHIBANA
Keyword(s):  
Chemical Potential ◽  
Critical Value ◽  
Composite Model ◽  
Color Superconductivity

A supersymmetric composite model of color superconductivity is proposed. Quarks and diquarks are dynamically generated as composite fields by a newly introduced strong gauge dynamics. It is shown that the condensation of the scalar component of the diquark supermultiplet occurs when the chemical potential becomes larger than some critical value. We believe that the model captures well the aspects of the diquark condensate behavior and helps in understanding the diquark dynamics in real QCD. The results obtained here might be useful when we consider a theory composed of quarks and diquarks.

scholarly journals CPU utilization prediction method based on composite model

2020 ◽  
Vol 1693 ◽  
pp. 012112
Author(s):  
Benran Hu ◽  
Wuzhuo Peng ◽  
Yanjun Li ◽  
Jiyuan Ren ◽  
Yiqun Li
Keyword(s):  
Prediction Method ◽  
Composite Model ◽  
Cpu Utilization

Nanograin Composite Model Studies of Nanocrystalline Gadolinia-Doped Ceria

2010 ◽  
Vol 94 (4) ◽  
pp. 1073-1078 ◽  
Author(s):  
Ted C. Yeh ◽  
Nicola H. Perry ◽  
Thomas O. Mason
Keyword(s):  
Composite Model ◽  
Doped Ceria ◽  
Model Studies

The estimation of inter-osteonal mechanical properties from a composite model for haversian bone

1985 ◽  
Vol 18 (7) ◽  
pp. 535
Author(s):  
J.Lawrence Katz ◽  
Hyo Sub Yoon ◽  
Russell L. Maharidge
Keyword(s):  
Mechanical Properties ◽  
Composite Model
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