scholarly journals Evaluation of changes in serum chemistry in association with feed withdrawal or high dose oral gavage with dextran sodium sulfate- (DSS-) induced gut leakage in broiler chickens

2016 ◽  
Vol 95 (11) ◽  
pp. 2565-2569 ◽  
Author(s):  
V.A. Kuttappan ◽  
E.A. Vicuña ◽  
O.B. Faulkner ◽  
G.R. Huff ◽  
K.A. Freeman ◽  
...  
Keyword(s):  
Sodium Sulfate ◽  
Broiler Chickens ◽  
Dextran Sodium Sulfate ◽  
High Dose ◽  
Serum Chemistry ◽  
Oral Gavage ◽  
Feed Withdrawal ◽  
Dose Oral ◽  
Gut Leakage

14-Day Repeat-Dose Oral Toxicity Evaluation of Oxazyme in Rats and Dogs

2009 ◽  
Vol 29 (1) ◽  
pp. 20-31 ◽  
Author(s):  
Aaron B. Cowley ◽  
Duane W. Poage ◽  
Robin R. Dean ◽  
Carol L. Meschter ◽  
Majid Ghoddusi ◽  
...  
Keyword(s):  
High Dose ◽  
Repeat Dose ◽  
Mutant Form ◽  
Oral Toxicity ◽  
Oral Gavage ◽  
Test Article ◽  
Adverse Effect Level ◽  
Dose Oral ◽  
Effect Level ◽  
Dietary Oxalate

Oxazyme (OC4) is an orally administered formulation that has as an active component a recombinant mutant form of Bacillus subtilis oxalate decarboxylase (OxDC) enzyme C383S, designed to degrade dietary oxalate in the stomach. Fourteen-day repeat-dose studies were conducted in rats and dogs to evaluate toxicity and determine a no observed adverse effect level (NOAEL). Animals were administered OC4 by oral gavage twice daily for 14 consecutive days. Reversibility, progression, and delayed appearance of any observed changes were evaluated in a subset of animals that underwent a recovery of 7 days following 14 days of control or test-article. There were no test-article-related adverse effects or deaths in either species. Results indicate that the NOAEL under the conditions used in the studies was 720.8 mg/kg/d in rats and 187.2 mg/kg/d in dogs, the high dose tested in each species.

Naringin protects against dextran sodium sulfate-induced colitis in mice

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
E Giner ◽  
M Marin ◽  
C Recio ◽  
J Ríos ◽  
R Giner
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate

Comparative effects of STW 5 and STW 5-II in dextran sodium sulfate-induced colitis

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
MT Khayyal ◽  
W Wadie ◽  
D Weiser ◽  
H Abdel-Aziz
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate
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