Interleukin-34 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis by Inhibiting the Epithelial Proliferation Through ERK Signal Pathway

The effect ofCordyceps militaris(CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC significantly suppressed DSS-induced disease activity index (DAI) as well as histopathological scores, compared to control or CM-treated group. To elucidate the anti-IBD activity of GSC, we checked the level of matrix metalloproteinases (MMPs) and inflammatory mediators. GSC extract decreased the level of MMP-3 and -9 mRNAs and p53 proteins. The level and activity of LPS-induced MMP-9 were reduced in GSC-treated RAW264.7 cells. It also attenuated the level of inducible nitric oxide synthase (iNOS) and tumor necrosis factor- (TNF-)αmRNAs both in colon tissue and in macrophage cells. These results suggest that GSC can be applied as a protective agent against IBDs.

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Beneficial Effect of Glatiramer Acetate Treatment on Syndecan-1 Expression in Dextran Sodium Sulfate Colitis

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.110.174276 ◽

2011 ◽

Vol 337 (2) ◽

pp. 391-399 ◽

Cited By ~ 5

Author(s):

Doron Yablecovitch ◽

Maytal Shabat-Simon ◽

Rina Aharoni ◽

Raya Eilam ◽

Ori Brenner ◽

...

Keyword(s):

Beneficial Effect ◽

Glatiramer Acetate ◽

Sodium Sulfate ◽

Dextran Sodium Sulfate

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THE EFFECT OF MAHKOTA DEWA (PHALERIA MACROCARPA) (SCHEFF.) FRUIT PERICARP EXTRACT ON INOS IN MICE COLON INTERMITTENTLY-INDUCED BY DEXTRAN SODIUM SULFATE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i12.20560 ◽

2017 ◽

Vol 10 (12) ◽

pp. 309

Author(s):

Kusmardi Kusmardi ◽

Dilla Shavera ◽

Ari Estuningtyas ◽

Aryo Tedjo ◽

Bambang Priyosoeryanto

Keyword(s):

Sodium Sulfate ◽

Total Yield ◽

Ethanolic Extract ◽

Dextran Sodium Sulfate ◽

Inflammatory Activity ◽

Fruit Pericarp ◽

Phaleria Macrocarpa ◽

Anti Inflammatory ◽

Oxide Synthase ◽

Different Doses

Objective: The objective of this research was to investigate the anti-inflammatory effect of Mahkota Dewa fruit pericarp extract (Phaleria macrocarpa) on inducible nitric oxide synthase (iNOS) in mice colon induced by dextran sodium sulfate (DSS).Method: The simplisia of P. macrocarpa pericarp was weighed (1000 g) and extracted by maceration process. The total yield of the ethanolic extract was 26.43%. Phytochemical screening was carried out for the detection of the phytoconstituents by simple qualitative methods. The anti-inflammatory activity was performed by DSS-induced colitis model through assessment of hematoxylin-eosin staining and expression of iNOS by immunohistochemistry assay at four different doses, i.e., 650, 1250, 2500, and 5000 mg/kg. Swiss Webster male mice weighing 25-30 g were used for the study.Results: Inflammation score in dose 625, 1250, 2500, and 5000 mg/kg were 1.63, 1.43, 1.32, and 2.20, respectively. This result is significantly different (p=0.008) with DSS group that was 4.37. The results of iNOS optical density score in dose 625, 1250, 2500, and 5000 mg/kg were 1.21, 1.119, 1.22, and 1.37, respectively. This result was significantly different (p=0.000) with DSS group that was 2.24.Conclusion: Pericarp extract of P. macrocarpa fruit exhibited anti-inflammatory activity in the experimental model shown by suppressing the expression of inflammatory cell and iNOS.

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Inhibition of dextran sodium sulfate-induced colitis in mice by baker’s yeast polysaccharides

Carbohydrate Polymers ◽

10.1016/j.carbpol.2018.11.087 ◽

2019 ◽

Vol 207 ◽

pp. 371-381 ◽

Cited By ~ 22

Author(s):

Ying Sun ◽

Xiaodan Shi ◽

Xing Zheng ◽

Shaoping Nie ◽

Xiaojuan Xu

Keyword(s):

Sodium Sulfate ◽

Baker’S Yeast ◽

Dextran Sodium Sulfate ◽

Baker's Yeast

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