scholarly journals Effects of Fortifying Low Crude Protein Diet with Crystalline Amino Acids on Performance, Blood Ammonia Level, and Excreta Characteristics of Broiler Chicks

2008 ◽  
Vol 87 (11) ◽  
pp. 2250-2258 ◽  
Author(s):  
N.F. Namroud ◽  
M. Shivazad ◽  
M. Zaghari
Keyword(s):  
Amino Acids ◽  
Crude Protein ◽  
Ammonia Level ◽  
Protein Diet ◽  
Broiler Chicks ◽  
Blood Ammonia ◽  
Blood Ammonia Level ◽  
Crystalline Amino Acids

scholarly journals High Blood Ammonia Levels Associated with Long-term Valproic Acids Therapy in Epileptic Children

2020 ◽  
Vol 4 (2) ◽  
pp. 83
Author(s):  
I Gusti Lanang Sidiartha ◽  
I Gusti Ngurah Made Suwarba ◽  
Dyah Kanya Wati ◽  
Ida Bagus Subanada
Keyword(s):  
Valproic Acid ◽  
Combination Therapy ◽  
Ammonia Level ◽  
Blood Ammonia ◽  
Cross Sectional ◽  
Acid Therapy ◽  
Blood Ammonia Level ◽  
Significant Difference ◽  
Epileptic Children

Background: Valproic acid is an effective drug for controlling seizure in children with epilepsy and it is usually used for treatment as long as two years or more. Blood ammonia level often increased in epileptic children who were treated with long-term valproic acid. The study was conducted to determine the relationship between blood ammonia level with valproic acid therapy in epileptic children.Materials and Methods: This is an observational study with cross-sectional approach. The subjects were 64 children with epilepsy, average age of 6.2 years old. Subjects were 33 boys and 31 girls. Blood ammonia level was examined using enzymatic glutamate dehydrogenase. Subjects were divided into 2 therapeutic groups based on the duration, doses and combination therapy of valproic acid. Subjects were recruited from Pediatric Neurology Clinic, Sanglah General Hospital, Bali, Indonesia, from May to December 2017. Comparison of blood ammonia level between groups were analyzed using an Independent t-test with significances if the p<0.05. Results: A significant difference of blood ammonia level was found between subjects who were treated with valproic acid less than 2 years and more than 2 years (45.7±16.4 mmol/L vs. 70.9±43.6 mmol/L; p=0.032). However, significant difference was not found between the groups according to the doses and combination therapy (p=0.450 and p=0.647, respectively).Conclusion: Blood ammonia level was significantly higher in epileptic children who used long-term valproic acid, hence it was recommended to check the blood ammonia level routinely.Keywords: ammonia, epilepsy, valproic, children

The Effect of Cisplatin on Blood Ammonia Elevation by Alanyl-Glutamine Supplementation

Pharmacology ◽  
2018 ◽  
Vol 101 (3-4) ◽  
pp. 156-162
Author(s):  
Yoko Obayashi ◽  
Kenta Kajiwara ◽  
Eiji Nakamura
Keyword(s):  
Beneficial Effect ◽  
Intravenous Infusion ◽  
Ammonia Level ◽  
Glutamine Supplementation ◽  
Glutamic Pyruvic Transaminase ◽  
Elevated Blood ◽  
Blood Ammonia ◽  
Renal Disorder ◽  
Blood Ammonia Level ◽  
Glutamate Oxaloacetic Transaminase

Background: Although there are many clinical studies in which the beneficial effect of glutamine formulation on mucositis induced by chemo/radiotherapy was evaluated, the results are sometimes conflicting with the report of clinical deterioration. Then, we hypothesized that chemotherapy may increase the incidence of hyperammonemia without comparable change of major parameters of hepatic/renal disorder. Methods: To verify our hypothesis, we examined the increase in blood ammonia level with 1-h intravenous infusion of alanyl-glutamine on day 1–4 after cisplatin (CDDP) administration in rats and assessed the correlation with hepatic/renal parameters. Results: Hepatic parameters (glutamate-oxaloacetic transaminase [GOT] and glutamic-pyruvic transaminase [GPT]) with CDDP did not change until day 3 and only GOT increased on day 4. Renal parameters (plasma creatinine, blood urea nitrogen) with CDDP continuously increased up to day 4. Alanyl-glutamine infusion significantly elevated blood ammonia level of CDDP rats with the peak on day 3, although the same dose did not change that of control rats. Conclusion: These results indicates that CDDP enhances the increase in blood ammonia level by glutamine supplementation without correlating with primary parameters for hepatic/renal dysfunction.

scholarly journals Proline as an essential amino acid for the young pig

1986 ◽  
Vol 55 (3) ◽  
pp. 659-668 ◽  
Author(s):  
Ronald O. Ball ◽  
James L. Atkinson ◽  
Henry S. Bayley
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
G Protein ◽  
Crude Protein ◽  
Protein Diet ◽  
Single Amino Acid ◽  
Amino Acid Supplementation ◽  
Protein Nitrogen ◽  
Dietary Amino Acids ◽  
Arginine Concentration

1. The catabolism of L-[ l-14C]phenylalanine was used to indicate the effects of single amino acid supplementation of an inadequate protein diet (200 g crude protein (nitrogen x 6.25)/kg) on the utilization of dietary amino acids in pigs of 2.5 kg body-weight reared on an adequate protein diet (240 g crude protein/kg) containing skim milk and a mixture of free amino acids.2. The oxidation of phenylalanine was decreased by the addition of proline or arginine to the inadequate protein diet but not by the addition of threonine, methionine, lysine or a mixture of essential amino acids, indicating that proline and arginine were limiting the utilization of dietary amino acids in the inadequate protein diet.3. Dietary proline concentrations of 13.9 and 14.2 g/kg minimized phenylalanine oxidation in diets containing 200 or 260 g protein/kg. This indicates a dietary proline requirement of 14 g/kg.4. Increasing the dietary arginine concentration in a diet containing 240 g protein/kg showed that an arginine concentration of 5.1 g/kg minimized phenylalanine oxidation. However, increasing the arginine concentration in a diet containing 200 g protein/kg increased phenylalanine oxidation, suggesting an amino acid imbalance involving arginine at this lower level of protein.

FEATHER GROWTH AND FEATHER COMPOSITION OF BROILER CHICKENS

1981 ◽  
Vol 61 (3) ◽  
pp. 769-773 ◽  
Author(s):  
MARY-LOU FISHER ◽  
S. LEESON ◽  
W. D. MORRISON ◽  
J. D. SUMMERS
Keyword(s):  
Amino Acids ◽  
Broiler Chickens ◽  
Crude Protein ◽  
Research Council ◽  
National Research Council ◽  
Essential Amino Acids ◽  
Controlled Environment ◽  
Broiler Chicks ◽  
Amino Acid Requirements ◽  
Methionine Content

Feather-sexed broiler chicks were reared in litter floor pens in a controlled environment building and offered mash diets meeting National Academy of Science-National Research Council specifications. Ten birds of each sex were killed at weekly intervals and individual feather weight recorded. These feathers were analyzed for crude protein and essential amino acids. From within five replicate pens of each sex, litter was removed weekly from 28 to 49 days, and molted feathers removed, cleaned and weighed. Feather weight was consistently correlated (P < 0.05) with body weight only from 5–7 wk of age. Females lost consistently more feathers than male birds, with this differential being a factor of 3.5. The methionine content of feathers decreased with age, while that of threonine, isoleucine and valine increased with age. The data are presented for use in model prediction of broiler amino acid requirements.

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