scholarly journals Long-Term Administration of Low Doses of Mycotoxins in Poultry

1987 ◽  
Vol 66 (1) ◽  
pp. 47-50 ◽  
Author(s):  
C. MICCO ◽  
M. MIRAGLIA ◽  
R. ONORI ◽  
A. IOPPOLO ◽  
A. MANTOVANI
Keyword(s):  
Low Doses ◽  
Term Administration

scholarly journals Preliminary Results on the Discontinuous Long-Term Administration of Subcutaneous Calciumheparin to Arteritic Patients. A Pharmacological Action Hypothesis

1977 ◽  
Author(s):  
C. Raby ◽  
H. Bertrand
Keyword(s):  
Subcutaneous Injection ◽  
Anticoagulant Activity ◽  
Pharmacological Action ◽  
Clinical Results ◽  
Low Doses ◽  
Preliminary Results ◽  
Term Administration ◽  
Calcium Heparin ◽  
The Relationship

Thirty five patients with severe evolutive arteriopathy were selected since following the advent of their first accident and although they received classical treatment they experienced at least one or sometimes several relapses of thrombosis. These patients were subjected to discontinuous subcutaneous ambulatory heparin treatment. This treatment consisted of two daily injections of 5,000–10,000 IU calcium-heparin (Calciparine) depending on each patient’s weight, during 30 days every three months. A backward survey of nine years for the patients first treated and of over two years for those most recently examined indicated that such patients never underwent recurrence of the disease and were considerably functionally improved. Experimentally in the animal and after subcutaneous injection of low doses of using 35s labeled heparin we have shown that heparin remains bound both on arterial and venous endothelium at least 15 hours after all anticoagulant activity has disappeared from circulating blood. As a rule and depending on individuals the relationship between the dose and the persistence of heparin bound on the wall is much more constant than that existing between the dose and the duration of the anticoagulant effect. Low doses (100-150 IU/kg in man) repeated twice a day will suffice to ensure the persistence of an endothelial coating. This coating could account for the excellent clinical results obtained.

Effect of Zinc or S-Adenosyl-l-methionine on Long Term Administration of Low Doses of Lead to Rats

1993 ◽  
Vol 73 (4) ◽  
pp. 189-191 ◽  
Author(s):  
Juan J. Muñoz ◽  
Cristina Roca ◽  
José L. Santos ◽  
Miguel Arroyo ◽  
Rafael E. Salamanca
Keyword(s):  
Low Doses ◽  
Term Administration

scholarly journals Torasemide: additional benefits for postmenopausal women with arterial hypertension

2013 ◽  
Vol 10 (2) ◽  
pp. 9-13 ◽  
Author(s):  
O N Tkacheva ◽  
N K Runikhina ◽  
N V Sharashkina
Keyword(s):  
Clinical Practice ◽  
Arterial Hypertension ◽  
Postmenopausal Women ◽  
Antihypertensive Effect ◽  
Low Doses ◽  
Electrolyte Metabolism ◽  
Renin Angiotensin Aldosterone System ◽  
Low Renin Hypertension ◽  
Term Administration

Effective and safe diuretic torasemide has additional effects of renin-angiotensin-aldosterone system blockage. Torasemide can be used as monotherapy or combined with other antihypertensives. In low doses torasemide produces pronounced antihypertensive effect without augmentation of excretion of potassium and water with urine. Long-term administration of torasemide was not associated with significant effects on lipid, purine, carbohydrate, or electrolyte metabolism parameters. Torasemide particularly effective in postmenopausal women, as these women are more likely formed low-renin hypertension. Therefore, torasemide can be used more widely in modern clinical practice.

scholarly journals Low Doses of Psilocybin and Ketamine Enhance Motivation and Attention in Poor Performing Rats: Evidence for an Antidepressant Property

2021 ◽  
Vol 12 ◽  
Author(s):  
Guy A. Higgins ◽  
Nicole K. Carroll ◽  
Matt Brown ◽  
Cam MacMillan ◽  
Leo B. Silenieks ◽  
...  
Keyword(s):  
Progressive Ratio ◽  
Break Point ◽  
Therapeutic Benefit ◽  
Low Doses ◽  
Plasma Exposure ◽  
Short Term ◽  
Major Depressive ◽  
Term Administration ◽  
Psychiatric Conditions

Long term benefits following short-term administration of high psychedelic doses of serotonergic and dissociative hallucinogens, typified by psilocybin and ketamine respectively, support their potential as treatments for psychiatric conditions such as major depressive disorder. The high psychedelic doses induce perceptual experiences which are associated with therapeutic benefit. There have also been anecdotal reports of these drugs being used at what are colloquially referred to as “micro” doses to improve mood and cognitive function, although currently there are recognized limitations to their clinical and preclinical investigation. In the present studies we have defined a low dose and plasma exposure range in rats for both ketamine (0.3–3 mg/kg [10–73 ng/ml]) and psilocybin/psilocin (0.05–0.1 mg/kg [7–12 ng/ml]), based on studies which identified these as sub-threshold for the induction of behavioral stereotypies. Tests of efficacy were focused on depression-related endophenotypes of anhedonia, amotivation and cognitive dysfunction using low performing male Long Evans rats trained in two food motivated tasks: a progressive ratio (PR) and serial 5-choice (5-CSRT) task. Both acute doses of ketamine (1–3 mg/kg IP) and psilocybin (0.05–0.1 mg/kg SC) pretreatment increased break point for food (PR task), and improved attentional accuracy and a measure of impulsive action (5-CSRT task). In each case, effect size was modest and largely restricted to test subjects characterized as “low performing”. Furthermore, both drugs showed a similar pattern of effect across both tests. The present studies provide a framework for the future study of ketamine and psilocybin at low doses and plasma exposures, and help to establish the use of these lower concentrations of serotonergic and dissociative hallucinogens both as a valid scientific construct, and as having a therapeutic utility.

Long‐term administration of low doses of mycotoxins to poultry. 1. Residues of aflatoxin B1and its metabolites in broilers and laying hens

1988 ◽  
Vol 5 (3) ◽  
pp. 303-308 ◽  
Author(s):  
C. Micco ◽  
M. Miraglia ◽  
R. Onori ◽  
C. Brera ◽  
Al. Mantovani ◽  
...  
Keyword(s):  
Laying Hens ◽  
Low Doses ◽  
Term Administration

Vascular Pathology in Male Lewis Rats following Short-Term, Low-Dose Rotenone Administration

2009 ◽  
Vol 46 (4) ◽  
pp. 776-782 ◽  
Author(s):  
A. L. Allen ◽  
C. Luo ◽  
D. L. Montgomery ◽  
A. H. Rajput ◽  
C. A. Robinson ◽  
...  
Keyword(s):  
Low Dose ◽  
Vascular Pathology ◽  
Low Doses ◽  
Short Term ◽  
Acute Hemorrhage ◽  
Lewis Rats ◽  
Small Arteries ◽  
Term Administration ◽  
The Brain

The long-term administration of low doses of rotenone has been used to produce a model of Parkinson disease (PD) in rats. However, only about 50% of similarly treated rats develop the PD-like syndrome, with many dying during the first few days of treatment. The lesions in male Lewis rats that became moribund or died after short-term, low-dose rotenone administration are described. Dosed rats had fibrinoid change and acute hemorrhage involving small arteries and arterioles of the brain and lungs. The thalamus, hypothalamus, and medulla oblongata were most frequently and severely affected. Blood vessels in the brain of some male Lewis rats appeared acutely susceptible to the effects of rotenone. Understanding the selective nature of the fibrinoid change and hemorrhage might explain how rotenone produces PD-like signs and lesions in rats, and it might also provide the basis for a model of intraparenchymal hemorrhagic cerebrovascular disease (i.e., hemorrhagic strokes) in humans.

scholarly journals Learning and Memory of Rats after Long-Term Administration of Low Doses of Parathion

1998 ◽  
Vol 46 (1) ◽  
pp. 101-111 ◽  
Author(s):  
I. A. Ivens ◽  
G. Schmuck ◽  
L. Machemer
Keyword(s):  
Learning And Memory ◽  
Low Doses ◽  
Term Administration

The efficacy and safety of long-term administration of alpha-interferon and lamivudine in patients with chronic hepatitits B

2001 ◽  
Vol 120 (5) ◽  
pp. A572-A572
Author(s):  
F JABOLI ◽  
E RODA ◽  
C FABBRI ◽  
S MARCHETTO ◽  
F FERRARA ◽  
...  
Keyword(s):  
Alpha Interferon ◽  
Efficacy And Safety ◽  
Term Administration
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