scholarly journals Torasemide: additional benefits for postmenopausal women with arterial hypertension

2013 ◽  
Vol 10 (2) ◽  
pp. 9-13 ◽  
Author(s):  
O N Tkacheva ◽  
N K Runikhina ◽  
N V Sharashkina
Keyword(s):  
Clinical Practice ◽  
Arterial Hypertension ◽  
Postmenopausal Women ◽  
Antihypertensive Effect ◽  
Low Doses ◽  
Electrolyte Metabolism ◽  
Renin Angiotensin Aldosterone System ◽  
Low Renin Hypertension ◽  
Term Administration

Effective and safe diuretic torasemide has additional effects of renin-angiotensin-aldosterone system blockage. Torasemide can be used as monotherapy or combined with other antihypertensives. In low doses torasemide produces pronounced antihypertensive effect without augmentation of excretion of potassium and water with urine. Long-term administration of torasemide was not associated with significant effects on lipid, purine, carbohydrate, or electrolyte metabolism parameters. Torasemide particularly effective in postmenopausal women, as these women are more likely formed low-renin hypertension. Therefore, torasemide can be used more widely in modern clinical practice.

scholarly journals Long-Term Administration of Low Doses of Mycotoxins in Poultry

1987 ◽  
Vol 66 (1) ◽  
pp. 47-50 ◽  
Author(s):  
C. MICCO ◽  
M. MIRAGLIA ◽  
R. ONORI ◽  
A. IOPPOLO ◽  
A. MANTOVANI
Keyword(s):  
Low Doses ◽  
Term Administration

Long-term administration of 1,3-dipropyl-8-sulfophenylxanthine causes arterial hypertension

1991 ◽  
Vol 193 (1) ◽  
pp. 101-104 ◽  
Author(s):  
Alexandra Matias ◽  
António Albino-Teixeira ◽  
Jorge Polónia ◽  
Isabel Azevedo
Keyword(s):  
Arterial Hypertension ◽  
Term Administration

Contractility of isolated aortic strips from rats with stable arterial hypertension due to long-term administration of cerebrosides

1985 ◽  
Vol 99 (6) ◽  
pp. 762-764
Author(s):  
S. A. Mirzoyan ◽  
O. P. Sotskii ◽  
�. S. Sekoyan ◽  
A. V. Topchyan ◽  
G. M. Sarkisova
Keyword(s):  
Arterial Hypertension ◽  
Term Administration

scholarly journals Glucocorticoids in Systemic Lupus Erythematosus. Ten Questions and Some Issues

2020 ◽  
Vol 9 (9) ◽  
pp. 2709
Author(s):  
Sabrina Porta ◽  
Alvaro Danza ◽  
Maira Arias Saavedra ◽  
Adriana Carlomagno ◽  
María Cecilia Goizueta ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Practice ◽  
Lupus Erythematosus ◽  
Low Cost ◽  
Rapid Decrease ◽  
Low Doses ◽  
Systemic Lupus ◽  
High Doses ◽  
Inflammatory Effect

Since the discovery of glucocorticoids (GCs), their important anti-inflammatory effect, rapid mechanism of action, low cost, and accessibility have made them one of the mainstays of treatment for Systemic lupus erythematosus (SLE). Although their use has allowed controlling the disease and reducing acute mortality in severe conditions, the implementation of a scheme based on high doses for long periods has inevitably been accompanied by an increase in adverse effects and infections, including long-term damage. The objective of this review is to answer some important questions that may arise from its use in daily clinical practice, and to propose a paradigm based on the use of methylprednisolone pulses followed by medium-low doses and a rapid decrease of prednisone.

scholarly journals Long-Term Administration of Beraprost Sodium for Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

2009 ◽  
Vol 48 (17) ◽  
pp. 1531-1534 ◽  
Author(s):  
Jun Oyamada ◽  
Manatomo Toyono ◽  
Shunsuke Shimada ◽  
Mieko Aoki-Okazaki ◽  
Masamichi Tamura ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Congenital Heart ◽  
Beraprost Sodium ◽  
Term Administration ◽  
Pulmonary Arterial

Long-term administration of protein hydrolysate from chicken feet induces antihypertensive effect and confers vasoprotective pattern in diet-induced hypertensive rats

2019 ◽  
Vol 55 ◽  
pp. 28-35 ◽  
Author(s):  
Anna Mas-Capdevila ◽  
Lisard Iglesias-Carres ◽  
Anna Arola-Arnal ◽  
Manuel Suarez ◽  
Begoña Muguerza ◽  
...  
Keyword(s):  
Antihypertensive Effect ◽  
Protein Hydrolysate ◽  
Hypertensive Rats ◽  
Term Administration

scholarly journals Preliminary Results on the Discontinuous Long-Term Administration of Subcutaneous Calciumheparin to Arteritic Patients. A Pharmacological Action Hypothesis

1977 ◽  
Author(s):  
C. Raby ◽  
H. Bertrand
Keyword(s):  
Subcutaneous Injection ◽  
Anticoagulant Activity ◽  
Pharmacological Action ◽  
Clinical Results ◽  
Low Doses ◽  
Preliminary Results ◽  
Term Administration ◽  
Calcium Heparin ◽  
The Relationship

Thirty five patients with severe evolutive arteriopathy were selected since following the advent of their first accident and although they received classical treatment they experienced at least one or sometimes several relapses of thrombosis. These patients were subjected to discontinuous subcutaneous ambulatory heparin treatment. This treatment consisted of two daily injections of 5,000–10,000 IU calcium-heparin (Calciparine) depending on each patient’s weight, during 30 days every three months. A backward survey of nine years for the patients first treated and of over two years for those most recently examined indicated that such patients never underwent recurrence of the disease and were considerably functionally improved. Experimentally in the animal and after subcutaneous injection of low doses of using 35s labeled heparin we have shown that heparin remains bound both on arterial and venous endothelium at least 15 hours after all anticoagulant activity has disappeared from circulating blood. As a rule and depending on individuals the relationship between the dose and the persistence of heparin bound on the wall is much more constant than that existing between the dose and the duration of the anticoagulant effect. Low doses (100-150 IU/kg in man) repeated twice a day will suffice to ensure the persistence of an endothelial coating. This coating could account for the excellent clinical results obtained.

Long-Term Treatment with Slow-Release Frusemide Compared with Thiazide Treatment in Arterial Hypertension

1989 ◽  
Vol 17 (6) ◽  
pp. 552-559 ◽  
Author(s):  
H. Jørgensen ◽  
N. Anderssen ◽  
T. Silsand ◽  
L.-E. Peterson
Keyword(s):  
Arterial Hypertension ◽  
Antihypertensive Effect ◽  
Slow Release ◽  
Serum Glucose ◽  
Term Treatment ◽  
Moderate Essential Hypertension ◽  
Fasting Serum ◽  
Long Term Treatment ◽  
Previously Treated

The effect of 30 mg/day slow-release frusemide given orally for 12 months was studied in 64 patients previously treated with thiazides for mild to moderate essential hypertension. Frusemide had a significant antihypertensive effect ( P<0.001), and compared to thiazides significantly reduced fasting serum glucose ( P<0.015), haemoglobin A1c ( P<0.025), albumin ( P<0.025) and serum calcium ( P<0.025), and significantly increased serum sodium and chloride concentrations ( P<0.0001). There was also a non-significant trend for frusemide to reduce serum total cholesterol, triglycerides and urate, and to increase serum potassium. Frusemide was well tolerated in all but three patients. It is concluded that slow-release frusemide has a comparable antihypertensive effect to that of thiazide diuretics, but has fewer metabolic side-effects, and should be used in preference to thiazides for the treatment of arterial hypertension when a diuretic is indicated.

Effect of Zinc or S-Adenosyl-l-methionine on Long Term Administration of Low Doses of Lead to Rats

1993 ◽  
Vol 73 (4) ◽  
pp. 189-191 ◽  
Author(s):  
Juan J. Muñoz ◽  
Cristina Roca ◽  
José L. Santos ◽  
Miguel Arroyo ◽  
Rafael E. Salamanca
Keyword(s):  
Low Doses ◽  
Term Administration
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