scholarly journals Experimentally Induced “Fatty Liver Syndrome” Condition in Laying Hens

1977 ◽  
Vol 56 (2) ◽  
pp. 517-520 ◽  
Author(s):  
R.H. Harms ◽  
D.A. Roland ◽  
C.F. SIMPSON
Keyword(s):  
Fatty Liver ◽  
Laying Hens ◽  
Experimentally Induced

scholarly journals Effects of Pyrroloquinoline Quinone on Lipid Metabolism and Anti-Oxidative Capacity in a High-Fat-Diet Metabolic Dysfunction-Associated Fatty Liver Disease Chick Model

2021 ◽  
Vol 22 (3) ◽  
pp. 1458
Author(s):  
Kai Qiu ◽  
Qin Zhao ◽  
Jing Wang ◽  
Guang-Hai Qi ◽  
Shu-Geng Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Liver Disease ◽  
Fatty Liver ◽  
Mitochondrial Biogenesis ◽  
Fatty Liver Disease ◽  
Laying Hens ◽  
Oxidative Capacity ◽  
Pyrroloquinoline Quinone ◽  
Metabolic Dysfunction

Metabolic dysfunction-associated fatty liver disease (MAFLD) and its interaction with many metabolic pathways raises global public health concerns. This study aimed to determine the therapeutic effects of Pyrroloquinoline quinone (PQQ, provided by PQQ.Na2) on MAFLD in a chick model and primary chicken hepatocytes with a focus on lipid metabolism, anti-oxidative capacity, and mitochondrial biogenesis. The MAFLD chick model was established on laying hens by feeding them a high-energy low-protein (HELP) diet. Primary hepatocytes isolated from the liver of laying hens were induced for steatosis by free fatty acids (FFA) and for oxidative stress by hydrogen peroxide (H2O2). In the MAFLD chick model, the dietary supplementation of PQQ conspicuously ameliorated the negative effects of the HELP diet on liver biological functions, suppressed the progression of MAFLD mainly through enhanced lipid metabolism and protection of liver from oxidative injury. In the steatosis and oxidative stress cell models, PQQ functions in the improvement of the lipid metabolism and hepatocytes tolerance to fatty degradation and oxidative damage by enhancing mitochondrial biogenesis and then increasing the anti-oxidative activity and anti-apoptosis capacity. At both the cellular and individual levels, PQQ was demonstrated to exert protective effects of hepatocyte and liver from fat accumulation through the improvement of mitochondrial biogenesis and maintenance of redox homeostasis. The key findings of the present study provide an in-depth knowledge on the ameliorative effects of PQQ on the progression of fatty liver and its mechanism of action, thus providing a theoretical basis for the application of PQQ, as an effective nutrient, into the prevention of MAFLD.

Comparative effects of genistein and bisphenol A on non-alcoholic fatty liver disease in laying hens

2021 ◽  
pp. 117795
Author(s):  
Xiaona Gao ◽  
Shuhui Liu ◽  
Chenchen Ding ◽  
Yufan Miao ◽  
Zhangshan Gao ◽  
...  
Keyword(s):  
Liver Disease ◽  
Bisphenol A ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Laying Hens ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Improving effect of dietary soybean phospholipids supplement on hepatic and serum indexes relevant to fatty liver hemorrhagic syndrome in laying hens

2017 ◽  
Vol 88 (11) ◽  
pp. 1860-1869 ◽  
Author(s):  
Fei Yang ◽  
Jiming Ruan ◽  
Tiancheng Wang ◽  
Junrong Luo ◽  
Huabin Cao ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Laying Hens ◽  
Soybean Phospholipids
Sign in / Sign up

Export Citation Format

Share Document