scholarly journals Therapeutic Potential of Gamma- Irradiated Resveratrol in Ulcerative Colitis via the Anti-Inflammatory Activity and Differentiation of Tolerogenic Dendritic Cells

2019 ◽  
Vol 52 (5) ◽  
pp. 1117-1138 ◽  
Keyword(s):  
Ulcerative Colitis ◽  
Dendritic Cells ◽  
Therapeutic Potential ◽  
Inflammatory Activity ◽  
Tolerogenic Dendritic Cells ◽  
Anti Inflammatory ◽  
Gamma Irradiated

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Planta Medica ◽  
2020 ◽  
Author(s):  
Deise Cristina Drummond Xavier Paes Lopes ◽  
Temistocles Barroso de Oliveira ◽  
Alessandra Lifsitch Viçosa ◽  
Simone Sacramento Valverde ◽  
Eduardo Ricci Júnior
Keyword(s):  
Web Of Science ◽  
Citation Index ◽  
Therapeutic Potential ◽  
Inflammatory Activity ◽  
Traditional Use ◽  
Scientific Databases ◽  
Research And Innovation ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Patent Survey

AbstractCompositae is the largest family of flowering plants, with more than 1600 genera and 22 000 species. It has many economic uses in foods, cosmetics, and pharmaceutics. The literature reports its numerous medicinal benefits and recognized anti-inflammatory activity. Thus, this study evaluated the technological trends of anti-inflammatory activity of Compositae, based on the survey of scientific databases, articles, and patents, as well as the website of the Brazilian National Health Regulatory Agency (ANVISA), which is responsible for registering and controlling of healthcare and cosmetic products in the Brazil. The survey was conducted between 2008 and 2018, in the databases Science Direct, Lilacs, PubMed, and Web of Science (main collection), as well as the SciELO Citation Index. The patent survey was carried out on the basis of the Derwent Innovations Index, an important source for worldwide patent consultation, which covers 20 y of registered patents. Despite the numerous studies involving species of the Compositae family in different models of anti-inflammatory activity, there are few records of patents or products on the market from these species for that purpose. Some species have a traditional use and are present even in the Phytotherapic Summary of the Brazilian Pharmacopeia. This review confirms the therapeutic potential of Compositae for the development of anti-inflammatory drugs and reinforces the need to develop competencies and reduce technological bottlenecks to promote research and innovation in biodiversity products.

scholarly journals Anti-Inflammatory Activity of N-docosahexaenoylethanolamine and N-eicosapentaenoylethanolamine in a Mouse Model of Lipopolysaccharide-Induced Neuroinflammation

2021 ◽  
Vol 22 (19) ◽  
pp. 10728
Author(s):  
Anna Tyrtyshnaia ◽  
Sophia Konovalova ◽  
Anatoly Bondar ◽  
Ekaterina Ermolenko ◽  
Ruslan Sultanov ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Long Term Potentiation ◽  
Inflammatory Activity ◽  
Treatment And Prevention ◽  
Term Potentiation ◽  
Urgent Task ◽  
Tnf Α ◽  
Microglia Polarization ◽  
Anti Inflammatory

The search for methods of cognitive impairment treatment and prevention in neurological and neurodegenerative diseases is an urgent task of modern neurobiology. It is now known that various diseases, accompanied by dementia, exhibit a pronounced neuroinflammation. Considering the significant docosahexaenoic and eicosapentaenoic polyunsaturated fatty acids’ therapeutic potential, we decided to investigate and compare anti-inflammatory activity of their N-acylethanolamine derivatives. As a result, we found that both N-docosahexaenoylethanolamine (synaptamide) and N-eicosapentaenoylethanolamine (EPEA) prevents an LPS-mediated increase in the proinflammatory cytokines TNF-α and IL-6 production in the SIM-A9 microglia culture. In an in vivo experiment, synaptamide reversed an increase in LPS-mediated hippocampal TNF-α and IL-1β, but EPEA did not. However, both compounds contributed to the microglia polarization towards the M2-phenotype. Synaptamide, rather than EPEA, inhibited the Iba-1-positive microglia staining area increase. However, both synaptamide and EPEA prevented the LPS-mediated astrogliosis. A study of BDNF immunoreactivity showed that synaptamide, but not EPEA, reversed an LPS-mediated decrease in BDNF production. Despite the more pronounced anti-inflammatory activity of synaptamide, both compounds were effective in maintaining a normal level of hippocampal long-term potentiation in neuroinflammation. The results indicate a high therapeutic potential for both compounds. However, some tests have shown higher activity of synaptamide compared to EPEA.

scholarly journals TIGIT-Fc as a Potential Therapeutic Agent for Fetomaternal Tolerance

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenyan Fu ◽  
Renfei Cai ◽  
Zetong Ma ◽  
Tian Li ◽  
Changhai Lei ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Immune Cell ◽  
Therapeutic Potential ◽  
Interleukin 10 ◽  
Immunological Tolerance ◽  
Tolerogenic Dendritic Cells ◽  
Immune Cell Subsets ◽  
Pregnant Mice ◽  
Antigen Presenting

The perfect synchronization of maternal immune-endocrine mechanisms and those of the fetus is necessary for a successful pregnancy. In this report, decidual immune cells at the maternal-fetal interface were detected that expressed TIGIT (T cell immunoreceptor with Ig and ITIM domains), which is a co-inhibitory receptor that triggers immunological tolerance. We generated recombinant TIGIT-Fc fusion proteins by linking the extracellular domain of TIGIT and silent Fc fragments. The treatment with TIGIT-Fc of human decidual antigen presenting cells (APCs), the decidual dendritic cells (dDCs), and decidual macrophages (dMϕs) increased the production of interleukin 10 and induced the decidua APCs to powerfully polarize the decidual CD4+ T cells toward a classic TH2 phenotype. We further proposed that Notch signaling shows a pivotal effect on the transcriptional regulation in decidual immune cell subsets. Moreover, the administration of TIGIT-Fc to CBA/J pregnant mice at preimplantation induced CD4+ forkhead box P3+ (Foxp3+) regulatory T cells and tolerogenic dendritic cells and increased pregnancy rates in an abortion-prone animal model stress. The results suggested the therapeutic potential of the TIGIT-Fc fusion protein in reinstating immune tolerance in failing pregnancies.

scholarly journals Anti-Inflammatory Effects of Saccharomyces Boulardii on Myeloid Dendritic Cells From Patients With Crohn's Disease and Ulcerative Colitis

2011 ◽  
Vol 140 (5) ◽  
pp. S-849
Author(s):  
Saskia Thomas ◽  
Diana Metzke ◽  
Yvonne Dörffel ◽  
Jürgen Schmitz ◽  
Andreas Radbruch ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dendritic Cells ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Saccharomyces Boulardii ◽  
Myeloid Dendritic Cells ◽  
Anti Inflammatory

scholarly journals Cholinergic anti-inflammatory pathway ameliorates murine experimental Th2-type colitis by suppressing the migration of plasmacytoid dendritic cells

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Yuya Kanauchi ◽  
Takeshi Yamamoto ◽  
Minako Yoshida ◽  
Yue Zhang ◽  
Jaemin Lee ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Therapeutic Potential ◽  
Plasmacytoid Dendritic Cells ◽  
Nerve Fibers ◽  
Chronic Inflammatory Bowel Disease ◽  
Jak2 Inhibitor ◽  
Cholinergic Pathway ◽  
Anti Inflammatory

AbstractUlcerative colitis (UC) is a chronic inflammatory bowel disease. Several studies have demonstrated that α7 nicotinic acetylcholine receptors (α7nAChRs) exert anti-inflammatory effects on immune cells and nicotine suppress UC onset and relapse. Plasmacytoid dendritic cells (pDCs) reportedly accumulate in the colon of UC patients. Therefore, we investigated the pathophysiological roles of α7nAChRs on pDCs in the pathology of UC using oxazolone (OXZ)-induced Th2-type colitis with BALB/c mice. 2-deoxy-D-glucose, a central vagal stimulant suppressed OXZ colitis, and nicotine also ameliorated OXZ colitis with suppressing Th2 cytokines, which was reversed by α7nAChR antagonist methyllycaconitine. Additionally, α7nAChRs were expressed on pDCs, which were located very close to cholinergic nerve fibers in the colon of OXZ mice. Furthermore, nicotine suppressed CCL21-induced bone marrow-derived pDC migration due to Rac 1 inactivation, which was reversed by methyllycaconitine, a JAK2 inhibitor AG490 or caspase-3 inhibitor AZ-10417808. CCL21 was mainly expressed in the isolated lymphoid follicles (ILFs) of the colon during OXZ colitis. The therapeutic effect of cholinergic pathway on OXZ colitis probably through α7nAChRs on pDCs were attributed to the suppression of pDC migration toward the ILFs. Therefore, the activation of α7nAChRs has innovative therapeutic potential for the treatment of UC.

ANTI-INFLAMMATORY ACTIVITY OF A ZINC-CONTAINING COMPOSITE IN THE PRESENCE OF SIMULATED ULCERATIVE COLITIS

2018 ◽  
Vol 67 (4) ◽  
Author(s):  
K.A. Apartsin ◽  
A.D. Kim ◽  
S.A. Lepekhova ◽  
Ya.A. Kostyro ◽  
E.Yu. Chashkova ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Anti-inflammatory Activity ofCarpinus tschonoskiiLeaves Extract in R848-stimulated Bone Marrow-derived Macrophages and Dendritic Cells

2012 ◽  
Vol 42 (1) ◽  
pp. 77 ◽  
Author(s):  
Sung-Ha Kang ◽  
Jung-Eun Koo ◽  
Hye-Jin Hong ◽  
Vivek Bhakta Mathema ◽  
Young-Sang Koh
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Inflammatory Activity ◽  
Anti Inflammatory
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