scholarly journals Variability of Peripheral Pulse Wave Velocity in Patients With Diabetes Mellitus Type 2 During Orthostatic Challenge

2021 ◽  
pp. S433-S441
Author(s):  
J SVAČINOVÁ ◽  
J HRUŠKOVÁ ◽  
J JAKUBÍK ◽  
K BUDINSKAYA ◽  
S HIDEGOVÁ ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Arterial Stiffness ◽  
Lower Extremity ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Whole Body ◽  
Mean Power ◽  
Postural Changes ◽  
Patients With Diabetes

Diabetes mellitus 2 (DM2) is the seventh cause of death worldwide. One of the reasons is late diagnosis of vascular damage. Pulse wave velocity (PWV) has become an independent marker of arterial stiffness and cardiovascular risk. Moreover, the previous studies have shown the importance of beat-to-beat PWV measurement due to its variability among the heart cycle. However, variability of PWV (PWVv) of the whole body hasn't been examined yet. We have studied a group of DM II and heathy volunteers, to investigate the beat-to-beat mean PWV (PWVm) and PWVv in the different body positions. PWV of left lower and upper extremities were measured in DM2 (7 m/8 f, age 68±10 years, BP 158/90±19/9 mm Hg) and healthy controls (5 m/6 f, age 23±2 years, BP 117/76±9/5 mm Hg). Volunteers were lying in the resting position and of head-up-tilt in 45° (HUT) for 6 min. PWVv was evaluated as a mean power spectrum in the frequency bands LF and HF (0.04-0.15 Hz, 0.15-0.5 Hz). Resting PWVm of upper extremity was higher in DM2. HUT increased lower extremity PWVm only in DM2. Extremities PWVm ratio was significantly lower in DM2 during HUT compared to controls. LF and HF PWVv had the same response to HUT. Resting PWVv was higher in DM2. Lower extremity PWVv increased during HUT in both groups. PWVm and PWVv in DM2 differed between extremities and were significantly influenced by postural changes due to hydrostatic pressure. Increased resting PWVm and PWVv in DM2 is a marker of increased arterial stiffness.

Six-channel ECG-based pulse wave velocity for assessing whole-body arterial stiffness

2012 ◽  
Vol 21 (3) ◽  
pp. 167-176 ◽  
Author(s):  
Hsien-Tsai Wu ◽  
Po-Chun Hsu ◽  
An-Bang Liu ◽  
Zong-Li Chen ◽  
Ruay-Ming Huang ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Whole Body

scholarly journals Insulin Increases Central Aortic Stiffness in Response To Hyperglycemia in Healthy Humans: A Randomized Four-Way Crossover Study

2021 ◽  
Author(s):  
William B Horton ◽  
Linda A Jahn ◽  
Lee M Hartline ◽  
Kevin W Aylor ◽  
James T Patrie ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Diastolic Blood Pressure ◽  
Wave Velocity ◽  
Wave Reflection ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Healthy Humans

Abstract Introduction: Increasing arterial stiffness is a feature of vascular aging that is accelerated by conditions that enhance cardiovascular risk, including diabetes mellitus. Multiple studies demonstrate divergence of carotid-femoral pulse wave velocity and augmentation index in persons with diabetes mellitus, though mechanisms responsible for this are unclear.Materials and Methods: We tested the effect of acutely and independently increasing plasma glucose, plasma insulin, or both on hemodynamic function and markers of arterial stiffness (including carotid-femoral pulse wave velocity, augmentation index, forward and backward wave reflection amplitude, and wave reflection magnitude) in a four-arm, randomized study of healthy young adults.Results: Carotid-femoral pulse wave velocity increased only during hyperglycemic-hyperinsulinemia (+0.36 m/s; p=0.032), while other markers of arterial stiffness did not change (all p>0.05). Heart rate (+3.62 bpm; p=0.009), mean arterial pressure (+4.14 mmHg; p=0.033), central diastolic blood pressure (+4.16 mmHg; p=0.038), and peripheral diastolic blood pressure (+4.09 mmHg; p=0.044) also significantly increased during hyperglycemic-hyperinsulinemia.Conclusions: We conclude that the acute combination of moderate hyperglycemia and hyperinsulinemia preferentially stiffens central elastic arteries. This effect may be due to increased sympathetic activity. (ClinicalTrials.gov number NCT03520569; registered 9 May 2018).

Abstract WP383: The Effect of Stretching on Pulse Wave Velocity

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Jeongok G Logan ◽  
Suk-Sun Kim ◽  
Mijung Lee ◽  
SeonAe Yeo
Keyword(s):  
Heart Rate ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Whole Body ◽  
Large Artery ◽  
Long Term Effects ◽  
Cardiovascular Morbidity And Mortality ◽  
Trunk Flexibility

Introduction: Large-artery stiffness is an independent predictor of hypertension which is a leading cause of excess cardiovascular morbidity and mortality. Carotid-femoral pulse wave velocity (cf-PWV) is considered the ‘gold-standard’ measure of arterial stiffness because it measures along the aorto-iliac pathway, which makes the largest contribution to the arterial buffering function. While there is well-documented evidence on the health benefits of aerobic and resistance exercise, the information for the effect of stretching on arterial stiffness is limited. Previous studies have shown that arterial stiffness is associated with trunk flexibility. Stretching exercise targeted to improve flexibility may exert a beneficial effect on reducing arterial stiffness. Purpose: This study aimed (1) to determine the association between trunk flexibility and arterial stiffness and (2) to examine whether one bout of stretching exercise will increase trunk flexibility and decrease arterial stiffness. Methods: Thirty healthy women (mean age = 44.37 years) were instructed to follow a 20-minute DVD demonstration of whole-body stretching. Before and after stretching, cf-PWV and trunk flexibility were measured by using the SphygmoCor system and by sit-and-reach test, respectively, as well as systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) by using a Welch Allyn Monitor. All data were measured after taking a 10-minute rest in a supine position. Results: cf-PWV was not related to trunk flexibility, however, cf-PWV was significantly decreased after stretching compared with before stretching (mean difference [MD]=.63, , p=.01). Trunk flexibility was also significantly increased after stretching (MD=-3.08, p=.00). Furthermore, while SBP and DBP did not change significantly, HR was significantly reduced after stretching compared with before stretching (MD=3.12, p=.00). Conclusions: Our results showed that one bout of stretching exercise had significant effects on reducing arterial stiffness and heart rate. Further testing of long-term effects of stretching exercise is warranted for development of preventative interventions to reduce arterial stiffness, an important subclinical biomarker of cardiovascular disease.

The Relationship Between Carotid Artery Structural Abnormality and Stiffness in Patients With Prehypertension

2021 ◽  
Vol 34 (8) ◽  
pp. 888-888
Author(s):  
Ling-yu Zhang ◽  
Jian-hua Li ◽  
Yi-hua Shen ◽  
Guo-yan Xu ◽  
Ying Han ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Carotid Artery ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Structural Abnormality ◽  
Resting Heart Rate ◽  
The Relationship

Abstract Background To investigate the difference of carotid structural abnormality and stiffness, and the relationship between carotid structural abnormality and stiffness in prehypertensive and normotensive subjects. Methods A total of 581 participants (270 with prehypertension, 311 normotensive control subjects) from the First Affiliated Hospital of Fujian Medical University were enrolled from January 2017 to March 2019. Body height/weight, resting heart rate, and blood pressure were recorded. Blood biochemical indexes and carotid–femoral pulse wave velocity were determined, and carotid ultrasonography was performed. Carotid intima–media thickness ≥1.0 mm and carotid–femoral pulse wave velocity ≥10.0 m/s were defined as carotid structural abnormality and arterial stiffness, respectively. Results The percentage of patients with carotid structural abnormality (60.7% vs. 51.4%), carotid–femoral pulse wave velocity [(8.78 ± 1.48) vs. (7.92 ± 1.30) m/s], and the percentage of patients with arterial stiffness (13.7% vs. 5.8%) were increased in the prehypertension group compared with the control group (all P < 0.05). In the prehypertension group, the percentage of patients with arterial stiffness in the abnormal carotid structure subgroup (n = 164) was higher than that in the normal carotid structure subgroup (n = 106) (20.1% vs. 3.8%, χ2 = 14.551, P < 0.001). Furthermore, carotid structural abnormality, age, diabetes mellitus, resting heart rate, systolic blood pressure, fasting blood glucose, glycosylated hemoglobin A1c, and hypoglycemic therapy were all correlated with arterial stiffness (all P < 0.05). After adjusting for other cardiovascular risk factors, multiple logistic regression analysis showed that carotid structural abnormality, age, diabetes mellitus, and resting heart rate were independently correlated with arterial stiffness, and patients with carotid structural abnormality had 5.25-fold higher risk of arterial stiffness than those with a normal carotid arterial structure (odds ratio = 5.250, 95% confidence interval 1.580–17.448, P = 0.007). However, in the normotensive group, no such relationships were observed between carotid artery structural abnormality and stiffness. Conclusions In prehypertensives but not normotensives, carotid artery structural abnormalities and stiffness are common, and independently correlated.

scholarly journals Correlation between sclerostin and Dickkopf-1 with aortic arterial stiffness in patients with type 2 diabetes: A prospective, cross-sectional study

2018 ◽  
Vol 16 (3) ◽  
pp. 281-288 ◽  
Author(s):  
Hsin-Yu Yang ◽  
Du-An Wu ◽  
Ming-Chun Chen ◽  
Bang-Gee Hsu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Aortic Stiffness ◽  
Pulse Wave ◽  
Dickkopf 1

Background: Sclerostin and Dickkopf-1 are extracellular inhibitors of the canonical Wnt/β-catenin signalling pathway, which is implicated in the development of arterial stiffness. However, the correlation between aortic stiffness and sclerostin or Dickkopf-1 levels in patients with type 2 diabetes mellitus is unknown. Methods: Fasting blood samples were collected from 125 patients with type 2 diabetes mellitus. Aortic stiffness was measured by carotid–femoral pulse wave velocity, and high aortic stiffness was defined by a carotid–femoral pulse wave velocity of >10 m/s. The serum sclerostin and Dickkopf-1 concentrations were determined using commercially available enzyme-linked immunosorbent assays. Results: In total, 46 patients with type 2 diabetes mellitus (36.8%) had high levels of aortic stiffness. Compared to the control group without aortic stiffness, this group was significantly older, had higher systolic and diastolic blood pressures, had higher blood urea nitrogen, creatinine, urinary albumin-to-creatinine ratio and serum sclerostin levels, and had significantly lower high-density lipoprotein cholesterol levels and estimated glomerular filtration rates. After adjusting for confounders, serum sclerostin [odds ratio = 1.005 (1.002–1.007), p = 0.002] levels remained an independent predictor of aortic stiffness. Multivariate analysis showed that the serum sclerostin level ( β = 0.374, adjusted R2 change = 0.221, p < 0.001) was positively associated with carotid–femoral pulse wave velocity. Conclusion: Serum levels of sclerostin, but not Dickkopf-1, are positively correlated with carotid–femoral pulse wave velocity and independently predict aortic stiffness in patients with type 2 diabetes mellitus.

scholarly journals Arterial stiffness evaluation by pulse wave velocity in hypertension and diabetes mellitus subjects

2016 ◽  
Vol 7 (3) ◽  
pp. 1195-1202
Author(s):  
Hongyu Wang ◽  
Jiyun Wang ◽  
Jinbo Liu ◽  
Yingyan Zhou ◽  
Huan Liu
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Vascular Diseases ◽  
Entire Group ◽  
Urine Albumin ◽  
Stiffness Evaluation

 Background: Arterial stiffness is an independent predictor for vascular diseases. Carotid-femoral pulse wave velocity (CFPWV) is a reliable index of arterial stiffness. In the present study, we investigated the possible risk factors involving CFPWV in hypertension and diabetes mellitus (DM) subjects.Methods: 425 subjects (M/F 168/257) from Shougang Corporation Examination Center were divided into four groups: healthy group (n=185), hypertension group (n=135), DM group (n=32), hypertension with DM group (n=73). CFPWV was measured by Complior apparatus.Results: Our results showed that CFPWV was significantly higher in hypertension subjects with DM than in healthy and hypertension group, respectively (12.00+2.57 vs 10.12+2.28 m/s; 12.00+2.57 vs 10.78+2.07 m/s, both p<0.05). CFPWV was positively correlated with age, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), fasting plasma glucose ( FBG), HbA1c, uric acid, Log NT-proBNP and Log Urine Albumin (microalbumin) Excretion [Log UAE] in the entire group(r=0.437, 0.410, 0.206, 0.423, 0.210, 0.275, 0.130, 0.135, 0.166, all p<0.05, respectively). Multivariate analysis showed that age, body mass index, SBP, PP, FBG were independent associating factors of CFPWV in all subjects (β=0.287, p<0.001; β= -0.194, p=0.003; β=0.223, p=0.001; β=0.293, p<0.001; β=0.161, p=0.008; respectively).Conclusions: Our present study suggested that CFPWV was significantly higher in hypertension subjects with DM compared to healthy and hypertension groups.Keywords: Carotid-femoral pulse wave velocity; Hypertension; Diabetes mellitus

scholarly journals Association of the Amount and Pattern of Physical Activity With Arterial Stiffness: The Maastricht Study

2020 ◽  
Vol 9 (20) ◽  
Author(s):  
Evelien J. Vandercappellen ◽  
Ronald M.A. Henry ◽  
Hans H.C.M. Savelberg ◽  
Julianne D. van der Berg ◽  
Koen D. Reesink ◽  
...  
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Intensity Physical Activity

Background Arterial stiffness is an independent risk factor for cardiovascular disease and can be beneficially influenced by physical activity. However, it is not clear how an individual’s physical activity pattern over a week is associated with arterial stiffness. Therefore, we examined the associations of the amount and pattern of higher intensity physical activity with arterial stiffness. Methods and Results Data from the Maastricht Study (n=1699; mean age: 60±8 years, 49.4% women, 26.9% type 2 diabetes mellitus) were used. Arterial stiffness was assessed by carotid‐to‐femoral pulse wave velocity and carotid distensibility. The amount (continuous variable as h/wk) and pattern (categorical variable) of higher intensity physical activity were assessed with the activPAL3. Activity groups were: inactive (<75 min/wk), insufficiently active (75–150 min/wk), weekend warrior (>150 min/wk in ≤2 sessions), and regularly active (>150 min/wk in ≥3 sessions). In the fully adjusted model (adjusted for demographic, lifestyle, and cardiovascular risk factors), higher intensity physical activity was associated with lower carotid‐to‐femoral pulse wave velocity (amount: β = −0.05, 95% CI, −0.09 to −0.01; insufficiently active: β = −0.33, 95% CI, −0.55 to −0.11; weekend warrior: β = −0.38, 95% CI, −0.64 to −0.12; and regularly active: β = −0.46, 95% CI, −0.71 to −0.21 [reference: inactive]). These associations were stronger in those with type 2 diabetes mellitus. There was no statistically significant association between higher intensity physical activity with carotid distensibility. Conclusions Participating in higher intensity physical activity was associated with lower carotid‐to‐femoral pulse wave velocity, but there was no difference between the regularly actives and the weekend warriors. From the perspective of arterial stiffness, engaging higher intensity physical activity, regardless of the weekly pattern, may be an important strategy to reduce the risk of cardiovascular disease, particularly in individuals with type 2 diabetes mellitus.

P6255Impact of whole grain consumption on arterial stiffness. Results of the Corinthian cross-sectional survey

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
G Vavouranaki ◽  
E Oikonomou ◽  
G Vogiatzi ◽  
G Lazaros ◽  
S Tsalamandris ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Whole Grain ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Group I ◽  
Group Ii

Abstract Introduction The benefits of certain dietary patterns on cardiovascular diseases has been questioned over the last years. Whole grain consumption has been one of the controversial issues regarding the effect on cardiovascular disease. In Greek rural population consumptions of bread is part of the daily meal and a possible source of whole grain. Purpose To investigated the effect of whole grain bread consumption on arterial stiffness in Mediterranean population. Methods In a cross-sectional survey (Corinthia study) volunteers subjects completed a food frequency questioner (FFQ), including a question of consumption of bread on regular basis, whole grain (group I) or not (group II). Medical history, lifestyle habits, anthropometric and vital signs, as well as, laboratory blood test were performed. All patients underwent carotid-femoral pulse wave velocity (C-F PWV) measurements which were obtained noninvasively by SphygmoCor devise. Results Among the 2043 volunteers 1389 patients had adequate quality of pulse wave velocity recordings and were regular consumers of bread. Whole grain bread was consumed by 473 subjects (male 37%, female 63%,) but 916 (male 43.1%, female 56.9%) did not consume. Subjects consuming whole grain bread were younger compare to those who were not (group I: 62±11 years vs. group II: 64±12 years, p=0.02), have lower C-F PWV (group I: 9.04±2.93 m/sec vs. group II: 9.57±2.76 m/sec, p=0.01) but no other statistical difference were observe among other parameters (i.e. hypertension, diabetes mellitus, BMI, smoking etc). Hierarchical multiple regression showed that whole grain consumption predicted pulse wave velocity statistically significantly (b=−0.33, 95% CI: −0.62, −0.17, p=0.03) in addition to age (b=0.09, 95% CI 0.08–0.10, p<0.001), systolic blood pressure (b=0.02, 95% CI 0.01, 0.03, p<0.001) beta=0.157) and diabetes mellitus (b=0.75, 95% CI 0.40, 1.09, p<0.001). Conclusion Whole grain bread consumption has a beneficial effect on arterial stiffness as detected by better carotid femoral pulse wave velocity. This may have a positively effect on cardiovascular diseases.

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