scholarly journals Forelimb Movement Disorder in Rat Experimental Model

2019 ◽  
pp. 1037-1042
Author(s):  
D. Marešová ◽  
K. Kotková ◽  
P. Kozler ◽  
J. Pokorný
Keyword(s):  
Motor Activity ◽  
Brain Edema ◽  
Movement Disorders ◽  
Experimental Models ◽  
Limb Movement ◽  
Spontaneous Motor Activity ◽  
Intact Group ◽  
Forelimb Movement ◽  
The Right ◽  
Neural Disorders

Study of motor activity is an important part of the experimental models of neural disorders of rats. It is used to study effects of the CNS impairment, however studies on the peripheral nervous system lesions are much less frequent. The aim of the study was to extend the spectrum of experimental models of anterior limb movement disorders in rats by blockade of the right anterior limb brachial plexus with the local anesthetic Marcaine (Ma), or with aqua for injection administered into the same location (Aq) (with control intact group C). Two other groups with anterior limb movement disorders underwent induction of cellular brain edema by water intoxication (MaWI and AqWI). Results showed a lower spontaneous motor activity of animals in all experimental groups versus controls, and lower spontaneous motor activity of animals in the MaWI group compared to other experimental groups in all categories. There was no difference in spontaneous activity between the groups Ma, Aq and AqWI. Our study indicates that alterations of spontaneous motor activity may result from the impaired forelimb motor activity induced by the anesthetic effect of Marcaine, by the volumetric effect of water, as a result of induced brain edema, or due to combination of these individual effects.

scholarly journals Potential of Pandanus odoratissimus as a CNS depressant in Swiss albino mice

2011 ◽  
Vol 47 (3) ◽  
pp. 629-634 ◽  
Author(s):  
Sama Raju ◽  
Narra Venkata Subbaiah ◽  
Kandukuri Sreeramulu Reddy ◽  
Amit Das ◽  
Krishnan Bala Murugan
Keyword(s):  
Motor Activity ◽  
Leaf Extract ◽  
Motor Coordination ◽  
Experimental Models ◽  
Spontaneous Motor Activity ◽  
Pentobarbital Sodium ◽  
Sleeping Time ◽  
Cns Depressant ◽  
Albino Mice ◽  
Pandanus Odoratissimus

In this study, several neuropharmacological effects of methanolic leaf extract of Pandanus odoratissimus (PO) (family; Pandanaceae) were studied in albino mice using various experimental models. The effect of PO on the CNS was studied by using different neuropharmacological paradigms including spontaneous motor activity, rota-rod performance and potentiation of Pentobarbital sodium sleeping time in albino mice. Preliminary phytochemical evaluation and acute toxicity studies were also carried out where LD50 >2000 mg/kg was considered non-toxic through acute exposure in rats by the oral route. The methanolic leaf extract (50,100 and 200 mg/kg i. p.) produced a reduction in spontaneous motor activity, motor coordination and prolonged Pentobarbital sodium sleeping time. Preliminary qualitative chemical studies indicated the presence of steroids, saponins, terpinoids, glycosides, tannins, flavonoids and phenolics in the extract. These observations suggest that the leaf of Pandanus odoratissimus contains some active principles which possess potential CNS-depressant action

Serotonin stimulates GH secretion through a direct pituitary action: studies in hypophysectomized autografted animals and in perifused pituitaries

1986 ◽  
Vol 113 (3) ◽  
pp. 317-322 ◽  
Author(s):  
F. López ◽  
D. Gónzalez ◽  
E. Aguilar
Keyword(s):  
Plasma Volume ◽  
Direct Action ◽  
Experimental Models ◽  
Male Rats ◽  
Blood Samples ◽  
Kidney Capsule ◽  
Gh Secretion ◽  
Significant Release ◽  
The Right ◽  
Dose Dependent

Abstract. To analyze a possible direct action of serotonin (5-hydroxytryptamine) at pituitary level in GH secretion, two experimental models were used: hypophysectomized autografted rats and perifused pituitaries. Adult male rats were hypophysectomized and their own pituitaries placed under the right kidney capsule. Ten days later an intra-atrial cannula was inserted. The next day, blood samples were obtained before and every 10 min during a 2 h period after the injection of saline or 5-hydroxytryptamin (1 or 2 mg/kg iv). Plasma volume was replaced with saline. Both doses of 5-hydroxytryptamine elicit a strong release of GH, the effect being dose-dependent. In pituitaries perifused with 5-hydroxytryptamine (100 μm during 115 min or 1, 10 and 100 μm during 15 min), a significant release of GH was also observed. These results suggested that 5-hydroxytryptamine may stimulate GH secretion through a direct pituitary action.

Gender-dependent reduction of spontaneous motor activity and growth in rats subjected to portacaval shunt

Hepatology ◽  
1994 ◽  
Vol 19 (2) ◽  
pp. 381-388 ◽  
Author(s):  
Hari S. Conjeevaram ◽  
Kevin D. Mullen ◽  
Elizabeth J. May ◽  
Arthur J. McCullough
Keyword(s):  
Motor Activity ◽  
Portacaval Shunt ◽  
Spontaneous Motor Activity

scholarly journals Acute Toxicity and Depressive Effect on Spontaneous Motor Activity of Piperidine N-Derivatives in Mice

1979 ◽  
Vol 99 (12) ◽  
pp. 1155-1160 ◽  
Author(s):  
KATSUHIKO KIMURA ◽  
MASAHUMI YOSHIDA ◽  
MASAO NAGAOKA ◽  
SHOZABURO OHGIYA
Keyword(s):  
Acute Toxicity ◽  
Motor Activity ◽  
Spontaneous Motor Activity ◽  
Depressive Effect

Experimental models for controlled burn injuries in rats: a systematic analysis of original methods and burn devices

2021 ◽  
Author(s):  
Stefan Morarasu ◽  
Bianca-Codrina Morarasu ◽  
Nicolae Ghețu ◽  
Mihail-Gabriel Dimofte ◽  
Radu Iliescu ◽  
...  
Keyword(s):  
Final Analysis ◽  
Experimental Models ◽  
Burn Injuries ◽  
Systematic Analysis ◽  
Experimental Burn ◽  
Controlled Burn ◽  
Histological Confirmation ◽  
The Right ◽  
Burn Depth

Abstract AIM Despite a wide variety of models found in literature, choosing the right one can be difficult as many of them are lacking precise methodology. This study aims to analyze and compare original burn models in terms of burn device and technique, parameters, and wound depth assessment. METHODS A systematic search was performed according to PRISMA guidelines on studies describing original experimental burn models in rats. The adapted PICO formula and ARRIVE checklist were followed for inclusion and assessment of quality of studies. Characteristics of animals, burn technique, burn parameters and method of histological confirmation of burn depth were recorded. RESULTS Twenty-seven studies were included in the final analysis. Most studies used direct contact with skin for burn infliction (n=20). The rat’s dorsum was the most common site (n=18). Ten studies used manually controlled burn devices, while ten designed automatic burn devices with control over temperature (n=10), exposure time (n=5), and pressure (n=5). Most studies (n=7) used a single biopsy taken from the center of the wound to confirm burn depth immediately after burn infliction. CONCLUSION From the wide variety of burn models in current literature, our study provides an overview of the most relevant experimental burn models in rats aiding researchers to understand what needs to be addressed when designing their burn protocol. Models cannot be compared as burn parameters variate significantly. Assessment of burn depth should be done in a standardized, sequential fashion in future burn studies to increase reproducibility.

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