scholarly journals Insulin-Like Growth Factor Axis in Pregnancy and Gestational Diabetes Mellitus

2019 ◽  
pp. 807-816 ◽  
Author(s):  
K. ANDERLOVÁ ◽  
A. CINKAJZLOVÁ ◽  
P. ŠIMJÁK ◽  
J. KLOUČKOVÁ ◽  
H. KRATOCHVÍLOVÁ ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factor ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Insulin Like Growth Factor ◽  
Igf System ◽  
Visceral Adipose ◽  
Regulation Of Growth ◽  
Igfbp 3

The insulin-like growth factor (IGF) is involved in the regulation of growth and metabolism. The aim of this study was to determine selected parameters of IGF system at systemic and local levels [subcutaneous (SAT) and visceral adipose tissue (VAT)] to assess its possible role in gestational diabetes mellitus (GDM). 37 pregnant women (21 with GDM and 16 without GDM) and 15 age-matched non-pregnant females were included in the study. Blood samples were taken in 28-32 and 36-38 weeks of gestation and 6-12 months after delivery. SAT and VAT samples were obtained during delivery or surgery. Compared with non-pregnant women, serum IGF-1 and IGFBP-3 were increased in both groups of pregnant women. IGF-2 was elevated only in GDM women from 36 weeks of gestation culminating 6 months after delivery (p=0.003). Serum IGFBP-3 was increased and IGFBP-4 decreased in GDM women vs. pregnant women without GDM during the whole study (IGFBP-3: p˂0.001 for GDM vs. non-GDM; IGFBP-4: p=0.004 for GDM vs. non-GDM). Pregnant women with GDM had decreased mRNA expression of IGF-1, IGF-1R and IGF-2R and IGFBP-4 in VAT and IGF-1R in SAT compared to pregnant women without GDM. Changes in local activity of IGF are associated with the development of GDM.

Subclinical Inflammation and Adipose Tissue Lymphocytes in Pregnant Females With Gestational Diabetes Mellitus

2020 ◽  
Vol 105 (11) ◽  
Author(s):  
Anna Cinkajzlová ◽  
Kateřina Anderlová ◽  
Patrik Šimják ◽  
Zdeňka Lacinová ◽  
Jana Kloučková ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Adipose Tissue ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Visceral Adipose Tissue ◽  
Subclinical Inflammation ◽  
Serum Samples ◽  
Pregnant Females ◽  
Visceral Adipose

Abstract Context Gestational diabetes mellitus (GDM) is accompanied by subclinical inflammation; however, little is known about local inflammation in adipose tissue and placenta. Objective To analyze systemic and local subclinical inflammation and adipose tissue lymphocyte content and phenotype in pregnant women with and without GDM. Design Observational study. Settings Academic hospital. Patients Twenty-one pregnant women with GDM (GDM group), 16 pregnant women without GDM (non-GDM group) and 15 nonpregnant control women (N group). Interventions Serum samples taken at 28 to 32 (visit 1 [V1]) and 36 to 38 (V2) gestational weeks and 6 to 12 months after delivery (V3) in the GDM and non-GDM group and before elective gynecological surgery in the N group. Subcutaneous (SAT) and visceral adipose tissue (VAT) obtained during cesarean delivery or surgery. Main Outcome Measures Serum levels and adipose tissue expression of proinflammatory cytokines, adipose tissue lymphocyte content and phenotype (for a subset of GDM and non-GDM subjects). Results Accented proinflammatory state in GDM was documented by increased circulating tumor necrosis factor-α (TNF-α) levels. In both groups of pregnant females total lymphocytes were higher in VAT compared to SAT. In GDM subjects B cells and NKT cells were higher in SAT compared to VAT and T helper cells were increased relative to SAT of non-GDM group, while no intercompartmental adipose tissue differences were seen in non-GDM women. Conclusions Pregnant females had higher total lymphocyte count in VAT relative to SAT regardless of GDM. In addition to increased systemic subclinical inflammation, GDM was associated with significant differences in lymphocyte composition between subcutaneous and visceral adipose tissue depots.

scholarly journals Insulin-Like Growth Factor Axis and Gestational Diabetes Mellitus: A Longitudinal Study in a Multiracial Cohort

Diabetes ◽  
2016 ◽  
Vol 65 (11) ◽  
pp. 3495-3504 ◽  
Author(s):  
Yeyi Zhu ◽  
Pauline Mendola ◽  
Paul S. Albert ◽  
Wei Bao ◽  
Stefanie N. Hinkle ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Longitudinal Study ◽  
Growth Factor ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Insulin Like Growth Factor

Thyroid function in pregnant women; relation to Gestational Diabetes Mellitus (GDM) and Body Mass Index (BMI)

2018 ◽  
Author(s):  
George Simeakis ◽  
Evangelia Vogiatzi ◽  
Panagiota Konstantakou ◽  
Evangelia Zapanti ◽  
Katerina Saltiki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Body Mass ◽  
Thyroid Function

86-LB: Elevated First-Trimester Neutrophil Count Is Associated with the Development of Gestational Diabetes Mellitus in Pregnant Women

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 86-LB
Author(s):  
TIANGE SUN ◽  
FANHUA MENG ◽  
RUI ZHANG ◽  
ZHIYAN YU ◽  
SHUFEI ZANG ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Neutrophil Count ◽  
First Trimester
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