scholarly journals Olfactory Bulbectomy in Methamphetamine-Treated Rat Mothers Induces Impairment in Somatic and Functional Development of Their Offspring

2017 ◽  
pp. S469-S479
Author(s):  
R. ŠLAMBEROVÁ ◽  
J. RUDÁ-KUČEROVÁ ◽  
Z. BABINSKÁ ◽  
M. ŠEVČÍKOVÁ
Keyword(s):  
Postnatal Development ◽  
Adult Male ◽  
Maternal Behavior ◽  
Saline Group ◽  
Olfactory Bulbectomy ◽  
Male Offspring ◽  
Maximal Velocity ◽  
Challenge Dose ◽  
Functional Development ◽  
Pup Development

Olfactory bulbectomy in rodents is considered a putative model of depression. Depression is often associated with drug addiction. Our previous studies demonstrated that methamphetamine (MA) administration to rat mothers affects both, mothers and their pups. The aim of the present study was to examine the effect of bulbectomy, as a model of depression, and MA administration on behavior of rat mothers and postnatal development of their pups. Adult female Wistar rats were randomly divided into two groups: bulbectomized (OBX) and sham-operated (SH). A period of 20 days was allowed for the development of the depressive-like phenotype. Animals were tested in the motor activity test and 2 % sucrose preference for anhedonia and hyperactive locomotor response to a novel environment, respectively. After then females were impregnated. Pregnant females were exposed to daily subcutaneous (s.c.) injection of MA (5 mg/kg) or saline (SA) during the entire gestation period. Postnatally, maternal behavior and pup development was examined. The effect of a challenge dose of MA (1 mg/kg, s.c.) on behavior was further examined in adult male offspring. Our results showed no differences in the maternal behavior as a matter of bulbectomy, only OBX rats slept more than all the SH controls. Pups from OBX mothers were born with lower birthweight and gained less weight during the postnatal development than pups from SH controls. Both, bulbectomy and MA administration, delayed the eyes opening. As a matter of functional development of the pups, maternal OBX procedure impaired the performance in the Bar-holding test, but only in saline group. OBX/SA group was the worst in the Bar-holding test relative to all the other groups. In addition, pups from OBX mothers dropped more boluses during the Bar-holding test, suggesting that they were more stressed. In adult male offspring, bulbectomy increased immobility only in the SA/SA group. Prenatal MA exposure increased locomotion, while decreasing immobility. In addition, challenge dose of MA in adulthood increased distance traveled, locomotion, rearing, and average and maximal velocity, while decreasing immobility and grooming. In conclusion, our results suggest that depressive-like phenotype of rat mothers induces impairment in somatic and functional development of their male offspring.

Hypoxia or nutrient restriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring

2006 ◽  
Vol 20 (8) ◽  
pp. 1251-1253 ◽  
Author(s):  
Yi Xu ◽  
Sarah J. Williams ◽  
Darryl O'brien ◽  
Sandra T. Davidge ◽  
Yi Xu ◽  
...  
Keyword(s):  
Adult Male ◽  
Cardiac Remodeling ◽  
Male Offspring ◽  
Nutrient Restriction ◽  
Postischemic Recovery

Exposure to threshold doses of nicotine in utero: II. Neuroendocrine response to nicotine in adult male offspring

1994 ◽  
Vol 83 (2) ◽  
pp. 278-284 ◽  
Author(s):  
Russell E. Poland ◽  
Preetam Lutchmansingh ◽  
Denise Au ◽  
Chrissy Hsieh ◽  
Susan Afrane ◽  
...  
Keyword(s):  
Adult Male ◽  
In Utero ◽  
Male Offspring ◽  
Neuroendocrine Response ◽  
Threshold Doses

scholarly journals Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring

2017 ◽  
Vol 5 (6) ◽  
pp. e13210 ◽  
Author(s):  
Marcia S. Silva ◽  
Fabiana Lúcio-Oliveira ◽  
Andre Souza Mecawi ◽  
Lucas F. Almeida ◽  
Silvia G. Ruginsk ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Offspring ◽  
Pregnancy And Lactation ◽  
Neuroendocrine Responses

Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats

Toxicology ◽  
2019 ◽  
Vol 418 ◽  
pp. 11-21 ◽  
Author(s):  
Shuwei Hu ◽  
Kexin Liu ◽  
Hanwen Luo ◽  
Dan Xu ◽  
Liaobin Chen ◽  
...  
Keyword(s):  
Adult Male ◽  
Cholesterol Synthesis ◽  
Male Offspring ◽  
Pka Pathway

Role of thyroxine on postnatal development of ileal active bile salt transport

1986 ◽  
Vol 251 (2) ◽  
pp. G237-G242 ◽  
Author(s):  
J. E. Heubi
Keyword(s):  
Thyroid Hormone ◽  
Postnatal Development ◽  
Active Transport ◽  
Salt Transport ◽  
Maximal Velocity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Taurocholate Transport

The role of thyroid hormone on the postnatal development of ileal active taurocholate transport uptake was measured by an in vitro incubation technique in Sprague-Dawley rats. In 16-day-old rats treated with pharmacological doses of L-thyroxine (50 micrograms X 100 g body wt-1 X day-1 on days 10-13), ileal active transport appeared precociously whose Km was 1.60 +/- 0.48 mM and Vapp (apparent maximal velocity) was 8.09 +/- 1.14 nmol X min-1 X mg dry wt-1, while age-matched shams had only passive diffusion of taurocholate. To determine whether enhanced endogenous secretion of thyroxine was capable of stimulating development of ileal active taurocholate transport, thyrotrophic stimulating hormone (TSH) (0.5 U/100 g body wt twice daily) was given on days 10-13, with uptake measured on day 16. Following TSH treatment, only passive transport for taurocholate was observed in the ileum; uptake rates were consistently higher than those for untreated controls at each study concentration. Thyroidectomy performed at age 14 days with uptake measured at age 21 days did not ablate development of ileal active transport but resulted in a significant reduction (P less than 0.001) in the Vapp (7.39 +/- 1.10 nmol X min-1 X mg dry wt-1) and a significant increase (P less than 0.014) in Km (1.72 +/- 0.53 mM) compared with age-matched controls. Thyroid hormone does not appear to be obligatory for the postnatal development of ileal active taurocholate transport.

Maternal soy protein isolate diet during lactation programmes to higher metabolic risk in adult male offspring

2020 ◽  
Vol 71 (8) ◽  
pp. 954-964
Author(s):  
Poliana Guiomar de Almeida Brasiel ◽  
Maíra Schuchter Ferreira ◽  
Adriana Moura Vieira ◽  
Mariana Sarto Figueiredo ◽  
Patrícia Cristina Lisboa ◽  
...  
Keyword(s):  
Adult Male ◽  
Soy Protein ◽  
Soy Protein Isolate ◽  
Protein Isolate ◽  
Male Offspring ◽  
Metabolic Risk

Cross-Generational THC Exposure Alters Heroin Reinforcement in Adult Male Offspring

2020 ◽  
Vol 212 ◽  
pp. 107985 ◽  
Author(s):  
Briana J. Hempel ◽  
Madeline E. Crissman ◽  
Aikerim Imanalieva ◽  
Mariam Melkumyan ◽  
Tania D. Weiss ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Offspring

scholarly journals Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet

2020 ◽  
Vol 21 (10) ◽  
pp. 3428 ◽  
Author(s):  
Mei-Hsin Hsu ◽  
Jiunn-Ming Sheen ◽  
I-Chun Lin ◽  
Hong-Ren Yu ◽  
Mao-Meng Tiao ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Cognitive Impairment ◽  
Adult Male ◽  
High Fat Diet ◽  
Dorsal Hippocampus ◽  
Fetal Brain ◽  
Male Offspring ◽  
High Fat ◽  
Peripheral Insulin Resistance

To examine the effects of maternal resveratrol in rats borne to dams with gestational high-fat diet (HFD)/obesity with or without postnatal high-fat diet. We first tested the effects of maternal resveratrol intake on placenta and male fetus brain in rats borne to dams with gestational HFD/obesity. Then, we assessed the possible priming effect of a subsequent insult, male offspring were weaned onto either a rat chow or a HFD. Spatial learning and memory were assessed by Morris water maze test. Blood pressure and peripheral insulin resistance were examined. Maternal HFD/obesity decreased adiponectin, phosphorylation alpha serine/threonine-protein kinase (pAKT), sirtuin 1 (SIRT1), and brain-derived neurotrophic factor (BDNF) in rat placenta, male fetal brain, and adult male offspring dorsal hippocampus. Maternal resveratrol treatment restored adiponectin, pAKT, and BDNF in fetal brain. It also reduced body weight, peripheral insulin resistance, increased blood pressure, and alleviated cognitive impairment in adult male offspring with combined maternal HFD and postnatal HFD. Maternal resveratrol treatment restored hippocampal pAKT and BDNF in rats with combined maternal HFD and postnatal HFD in adult male offspring dorsal hippocampus. Maternal resveratrol intake protects the fetal brain in the context of maternal HFD/obesity. It effectively reduced the synergistic effects of maternal HFD/obesity and postnatal HFD on metabolic disturbances and cognitive impairment in adult male offspring. Our data suggest that maternal resveratrol intake may serve as an effective therapeutic strategy in the context of maternal HFD/obesity.

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