scholarly journals Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring

2017 ◽  
Vol 5 (6) ◽  
pp. e13210 ◽  
Author(s):  
Marcia S. Silva ◽  
Fabiana Lúcio-Oliveira ◽  
Andre Souza Mecawi ◽  
Lucas F. Almeida ◽  
Silvia G. Ruginsk ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Offspring ◽  
Pregnancy And Lactation ◽  
Neuroendocrine Responses

scholarly journals High-Fat Diet During Mouse Pregnancy and Lactation Targets GIP-Regulated Metabolic Pathways in Adult Male Offspring

Diabetes ◽  
2015 ◽  
Vol 65 (3) ◽  
pp. 574-584 ◽  
Author(s):  
Michael Kruse ◽  
Farnaz Keyhani-Nejad ◽  
Frank Isken ◽  
Barbara Nitz ◽  
Anja Kretschmer ◽  
...  
Keyword(s):  
Adult Male ◽  
Metabolic Pathways ◽  
High Fat Diet ◽  
Male Offspring ◽  
High Fat ◽  
Pregnancy And Lactation

Maternal exposure to diets containing flaxseed flour or flaxseed oil during pregnancy and lactation protects the aortic remodeling in adult male offspring of diabetic rat dams

2015 ◽  
Vol 95 (14) ◽  
pp. 2973-2980 ◽  
Author(s):  
Gabriela Câmara Vicente ◽  
André Manoel Correia-Santos ◽  
Akemi Suzuki ◽  
Luis Guillermo Coca Velarde ◽  
Maurício Alves Chagas ◽  
...  
Keyword(s):  
Adult Male ◽  
Flaxseed Oil ◽  
Maternal Exposure ◽  
Male Offspring ◽  
Diabetic Rat ◽  
Flaxseed Flour ◽  
Pregnancy And Lactation ◽  
Aortic Remodeling

scholarly journals Altered Gut Microbiota and Its Metabolites in Hypertension of Developmental Origins: Exploring Differences between Fructose and Antibiotics Exposure

2021 ◽  
Vol 22 (5) ◽  
pp. 2674
Author(s):  
Chien-Ning Hsu ◽  
Julie Y. H. Chan ◽  
Kay L. H. Wu ◽  
Hong-Ren Yu ◽  
Wei-Chia Lee ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Negative Impact ◽  
Short Chain Fatty Acids ◽  
Normal Diet ◽  
Male Offspring ◽  
Sprague Dawley ◽  
Minocycline Treatment ◽  
High Fructose ◽  
Induced Hypertension ◽  
Pregnancy And Lactation

Gut microbiota-derived metabolites, in particular short chain fatty acids (SCFAs) and their receptors, are linked to hypertension. Fructose and antibiotics are commonly used worldwide, and they have a negative impact on the gut microbiota. Our previous study revealed that maternal high-fructose (HF) diet-induced hypertension in adult offspring is relevant to altered gut microbiome and its metabolites. We, therefore, intended to examine whether minocycline administration during pregnancy and lactation may further affect blood pressure (BP) programmed by maternal HF intake via mediating gut microbiota and SCFAs. Pregnant Sprague-Dawley rats received a normal diet or diet containing 60% fructose throughout pregnancy and lactation periods. Additionally, pregnant dams received minocycline (50 mg/kg/day) via oral gavage or a vehicle during pregnancy and lactation periods. Four groups of male offspring were studied (n = 8 per group): normal diet (ND), high-fructose diet (HF), normal diet + minocycline (NDM), and HF + minocycline (HFM). Male offspring were killed at 12 weeks of age. We observed that the HF diet and minocycline administration, both individually and together, causes the elevation of BP in adult male offspring, while there is no synergistic effect between them. Four groups displayed distinct enterotypes. Minocycline treatment leads to an increase in the F/B ratio, but decreased abundance of genera Lactobacillus, Ruminococcus, and Odoribacter. Additionally, minocycline treatment decreases plasma acetic acid and butyric acid levels. Hypertension programmed by maternal HF diet plus minocycline exposure is related to the increased expression of several SCFA receptors. Moreover, minocycline- and HF-induced hypertension, individually or together, is associated with the aberrant activation of the renin–angiotensin system (RAS). Conclusively, our results provide a new insight into the support of gut microbiota and its metabolite SCAFs in the developmental programming of hypertension and cast new light on the role of RAS in this process, which will help prevent hypertension programmed by maternal high-fructose and antibiotic exposure.

Hypoxia or nutrient restriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring

2006 ◽  
Vol 20 (8) ◽  
pp. 1251-1253 ◽  
Author(s):  
Yi Xu ◽  
Sarah J. Williams ◽  
Darryl O'brien ◽  
Sandra T. Davidge ◽  
Yi Xu ◽  
...  
Keyword(s):  
Adult Male ◽  
Cardiac Remodeling ◽  
Male Offspring ◽  
Nutrient Restriction ◽  
Postischemic Recovery

Exposure to threshold doses of nicotine in utero: II. Neuroendocrine response to nicotine in adult male offspring

1994 ◽  
Vol 83 (2) ◽  
pp. 278-284 ◽  
Author(s):  
Russell E. Poland ◽  
Preetam Lutchmansingh ◽  
Denise Au ◽  
Chrissy Hsieh ◽  
Susan Afrane ◽  
...  
Keyword(s):  
Adult Male ◽  
In Utero ◽  
Male Offspring ◽  
Neuroendocrine Response ◽  
Threshold Doses

Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats

Toxicology ◽  
2019 ◽  
Vol 418 ◽  
pp. 11-21 ◽  
Author(s):  
Shuwei Hu ◽  
Kexin Liu ◽  
Hanwen Luo ◽  
Dan Xu ◽  
Liaobin Chen ◽  
...  
Keyword(s):  
Adult Male ◽  
Cholesterol Synthesis ◽  
Male Offspring ◽  
Pka Pathway

scholarly journals Effects of combined exposure of adult male mice to di-(2-ethylexyl)phthalate and nonylphenol on behavioral and neuroendocrine responses

Chemosphere ◽  
2019 ◽  
Vol 221 ◽  
pp. 573-582 ◽  
Author(s):  
Daphné Capela ◽  
Kevin Poissenot ◽  
Carlos Dombret ◽  
Matthieu Keller ◽  
Isabelle Franceschini ◽  
...  
Keyword(s):  
Adult Male ◽  
Combined Exposure ◽  
Male Mice ◽  
Neuroendocrine Responses
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