scholarly journals Effects of Body Weight Reduction on Plasma Leptin and Adiponectin/Leptin Ratio in Obese Patients With Type 1 Diabetes Mellitus

2015 ◽  
pp. 221-228 ◽  
Author(s):  
F. MUSIL ◽  
V. BLAHA ◽  
R. HYSPLER ◽  
M. HALUZIK ◽  
J. LESNA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Obese Patients ◽  
Low Calorie ◽  
Body Weight Reduction ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Plasma Leptin

The aim of this study was to explore the changes in the adipokines leptin and adiponectin in obese patients with type 1 diabetes mellitus (T1DM) who underwent seven days of fasting and 21 days of low-calorie diet (LCD). The plasma leptin and adiponectin concentrations were measured in 14 obese patients with T1DM at baseline, immediately after 7 days of fasting, and after 21 days of LCD. 13 non-obese patients with T1DM were studied only after an overnight fasting. Bioimpedance technique was used for determination of body composition. Obese T1DM patients lost 6.0 kg (6.0; 6.8) (median, 25 %; 75 %) and decreased their fat tissue after fasting and LCD. Plasma leptin in obese T1DM was significantly higher than in non-obese T1DM patients: 9.10 (5.06; 25.89) vs. 1.71 (1.12; 7.08) µg ∙ l−1 and transiently decreased immediately after fasting: 3.45 µg ∙ l−1 (1.47; 7.00), (P<0.05). Adiponectin/leptin ratio in obese T1DM was significantly lower than in non-obese T1DM patients: 0.67 (0.57; 1.49) vs. 3.50 (2.46; 6.30) ∙ 103 and transiently increased immediately after fasting: 2.22 (1.26; 3.24) ∙ 103, (P<0.05). We conclude that obese patients with T1DM are characterized by hyperleptinemia that is reduced by prolonged fasting, but only slightly affected by low calorie diet.

Effects of body weight reduction on body fat and plasma leptin in obese patients with type 1 diabetes mellitus

Nutrition ◽  
2013 ◽  
Vol 29 (11-12) ◽  
pp. 1435-1436
Author(s):  
F. Musil ◽  
V. Blaha ◽  
A. Ticha ◽  
R. Hyspler ◽  
M. Haluzik ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Body Weight ◽  
Type 1 Diabetes Mellitus ◽  
Body Fat ◽  
Weight Reduction ◽  
Obese Patients ◽  
Body Weight Reduction ◽  
Plasma Leptin

scholarly journals Effect of Low Calorie Diet and Controlled Fasting on Insulin Sensitivity and Glucose Metabolism in Obese Patients With Type 1 Diabetes Mellitus

2013 ◽  
pp. 267-276 ◽  
Author(s):  
F. MUSIL ◽  
A. ŠMAHELOVÁ ◽  
V. BLÁHA ◽  
R. HYŠPLER ◽  
A. TICHÁ ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Insulin Sensitivity ◽  
Glucose Metabolism ◽  
Glucose Oxidation ◽  
Glucose Disposal ◽  
Obese Patients ◽  
Low Calorie Diet ◽  
Calorie Diet

Obesity in T1DM patients is associated with the components of metabolic syndrome. The influence of controlled fasting and low calorie diet (LCD) on insulin sensitivity and glucose metabolism was studied in 14 obese patients with type 1 diabetes mellitus (T1DM) (42.6±9.4 years, BMI 32.4±2.1 kg m−2). Insulin sensitivity in obese T1DM patients was measured using a hyperinsulinemic-euglycemic clamp before fasting, immediately after 7 days of fasting, and after 21 days of LCD. Glucose oxidation and non-oxidative glucose disposal were measured before and during the clamp by indirect calorimetry. In the control group of 13 of non-obese T1DM patients (36.9±13.9 years, BMI 22.6±2.1 kg m−2), only one hyperinsulinemic-euglycemic clamp was performed. Obese T1DM patients lost 6.1±1.1 kg after fasting and maintained reduction in body weight after 21 days of LCD. Fasting transiently reduced insulin-mediated glucose disposal in the clamp (from 9.69±1.48 to 6.78±1.21 mg min−1 kg−1, P<0.001). This was caused by reduced glucose oxidation after the fasting period (from 2.81±0.52 to 0.88±0.98 mg min−1 kg−1, P<0.001). We conclude that one week of fasting transiently decreased insulin-mediated glucose disposal in T1DM patients. This was caused by reduced glucose oxidation.

Liraglutide as Additional Treatment to Insulin in Obese Patients with Type 1 Diabetes Mellitus

2013 ◽  
Vol 19 (6) ◽  
pp. 963-967 ◽  
Author(s):  
Nitesh Kuhadiya ◽  
Ritu Malik ◽  
Natalie Bellini ◽  
Jane Patterson ◽  
Andrea Traina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Additional Treatment ◽  
Obese Patients
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