Effects of body weight reduction on body fat and plasma leptin, and adiponectin/leptin ratio in obese patients with type 1 diabetes mellitus

Nutrition ◽  
2014 ◽  
Vol 30 (10) ◽  
pp. 1223 ◽  
Author(s):  
F. Musil ◽  
V. Blaha ◽  
A. Ticha ◽  
R. Hyspler ◽  
M. Haluzik ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Body Weight ◽  
Type 1 Diabetes Mellitus ◽  
Body Fat ◽  
Weight Reduction ◽  
Obese Patients ◽  
Body Weight Reduction ◽  
Plasma Leptin

Effects of body weight reduction on body fat and plasma leptin in obese patients with type 1 diabetes mellitus

Nutrition ◽  
2013 ◽  
Vol 29 (11-12) ◽  
pp. 1435-1436
Author(s):  
F. Musil ◽  
V. Blaha ◽  
A. Ticha ◽  
R. Hyspler ◽  
M. Haluzik ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Body Weight ◽  
Type 1 Diabetes Mellitus ◽  
Body Fat ◽  
Weight Reduction ◽  
Obese Patients ◽  
Body Weight Reduction ◽  
Plasma Leptin

scholarly journals Effects of Body Weight Reduction on Plasma Leptin and Adiponectin/Leptin Ratio in Obese Patients With Type 1 Diabetes Mellitus

2015 ◽  
pp. 221-228 ◽  
Author(s):  
F. MUSIL ◽  
V. BLAHA ◽  
R. HYSPLER ◽  
M. HALUZIK ◽  
J. LESNA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Obese Patients ◽  
Low Calorie ◽  
Body Weight Reduction ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Plasma Leptin

The aim of this study was to explore the changes in the adipokines leptin and adiponectin in obese patients with type 1 diabetes mellitus (T1DM) who underwent seven days of fasting and 21 days of low-calorie diet (LCD). The plasma leptin and adiponectin concentrations were measured in 14 obese patients with T1DM at baseline, immediately after 7 days of fasting, and after 21 days of LCD. 13 non-obese patients with T1DM were studied only after an overnight fasting. Bioimpedance technique was used for determination of body composition. Obese T1DM patients lost 6.0 kg (6.0; 6.8) (median, 25 %; 75 %) and decreased their fat tissue after fasting and LCD. Plasma leptin in obese T1DM was significantly higher than in non-obese T1DM patients: 9.10 (5.06; 25.89) vs. 1.71 (1.12; 7.08) µg ∙ l−1 and transiently decreased immediately after fasting: 3.45 µg ∙ l−1 (1.47; 7.00), (P<0.05). Adiponectin/leptin ratio in obese T1DM was significantly lower than in non-obese T1DM patients: 0.67 (0.57; 1.49) vs. 3.50 (2.46; 6.30) ∙ 103 and transiently increased immediately after fasting: 2.22 (1.26; 3.24) ∙ 103, (P<0.05). We conclude that obese patients with T1DM are characterized by hyperleptinemia that is reduced by prolonged fasting, but only slightly affected by low calorie diet.

Dietary intake, body composition, and physical activity among young patients with type 1 diabetes mellitus

2015 ◽  
Vol 28 (7-8) ◽  
Author(s):  
Constanza Mosso ◽  
Victoria Halabi ◽  
Tamara Ortiz ◽  
Maria Isabel Hodgson
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Body Composition ◽  
Dietary Intake ◽  
Type 1 Diabetes Mellitus ◽  
Body Fat ◽  
Activity Level ◽  
The Mean

AbstractThe aim of this study was to assess dietary intake, nutritional status, body composition, and physical activity level in a group of Chilean children and adolescents with Type 1 diabetes mellitus (T1DM), compare these parameters with the recommendations of the International Society for Pediatric and Adolescent Diabetes (ISPAD), and determine the relationships between dietary intake, body composition, and diabetes control.A total of 30 patients with T1DM (aged 15.2±4.0 years) were included. Dietary intake was assessed using a 92-item quantitative food frequency questionnaire. Body composition was determined using dual-energy X-ray densitometry. Physical activity was assessed by means of a survey.The energy intake of these patients was derived from 21.4% protein, 48% carbohydrates, and 31.2% fat. The glycosylated hemoglobin (HbA1c) was significantly correlated with fat as grams per day (r: 0.363, p<0.05) and calories per day (r: 0.364, p<0.05). The mean body fat percentage in females was 31.2% and 20.2% in males (p < 0.01) and the mean amount of physical activity was 4.5±2.7 h per week.The study patients had a higher protein intake than recommended by ISPAD. Dietary carbohydrate intake was rather low, and dietary fat intake was the same as the limits recommended by ISPAD. Diabetic control was significantly correlated with protein, carbohydrates, fat, and sodium intake. The girls in the study had a higher percentage of body fat than the standard recommendations for their age. The level of physical activity was adequate.

scholarly journals The Role of SGLT-2 Inhibitors as an Adjuvant to Insulin Therapy in Type-1 Diabetes Mellitus- Literature Review

2021 ◽  
pp. 333-337
Author(s):  
Sultan Ali Alshehri ◽  
Sultan Abdulwahab M. Asiri ◽  
Aalaa Mohammad Algarni ◽  
Manal Mohammed Alamari
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Body Weight ◽  
Insulin Therapy ◽  
Type 1 Diabetes Mellitus ◽  
Insulin Regimen ◽  
Increase Body Weight ◽  
Pubmed Database

Background: Type 1 diabetes mellitus is the main risk factor for cardiovascular complications. Therefore, intensified insulin therapy might be needed to achieve better glycemic control in some patients. However, insulin therapy might lead to increase body weight and induce hypoglycemia. Increase body weight is directly correlated to insulin resistance, the main factor for cardiovascular risk.  Objective: To assess the effectiveness of adding SGLT2 inhibitors to insulin therapy in type 1 diabetes mellitus.  Methods: We searched in the PubMed database looking for relevant articles on the topic. We used Mesh words search, including SGLT2 inhibitor, sotagliflozin, type 1 diabetes mellitus, insulin treatment.  Conclusion: Adding oral antidiabetic agents, such as SGLT2 or dual SGLT inhibitors to insulin regimen might be beneficial in improving insulin resistance. Thus, it achieved better insulin resistance by decrease daily insulin requirements and bodyweight control, leading to better cardiovascular outcomes among Type-1 diabetes patients.

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