scholarly journals Apolipoprotein E/intrauterine undernutrition interaction and hypercholesterolemia in children

2008 ◽  
pp. 965-968
Author(s):  
P Szitányi ◽  
H Pistulková ◽  
JA Hubáček ◽  
H Stuchlíková ◽  
R Poledne
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Gene Polymorphism ◽  
Apolipoprotein E ◽  
High Cholesterol ◽  
Apo E ◽  
Low Cholesterol ◽  
Intrauterine Programming

The inconsistency of data regarding intrauterine programming of cardiovascular risk factors may be largely caused by genetic predisposition and later lifestyle. We analyzed whether low birth weight and apolipoprotein E (Apo E) polymorphism participate in the onset of hypercholesterolemia in children. Our approach was based on hypothesis that genetically enhanced susceptibility of different individuals might influence the effects of intrauterine programming. Two groups were selected from 2000 children at the beginning of an ongoing study: high-cholesterol group (HCG, n=67) and low-cholesterol group as a control (LCG, n=72). Both groups were divided into tertilles according to birth weight and we compared birth weight and apo E gene polymorphism between and within groups. The birth weight in HCG was 0.3 kg lower than the controls (p<0.001). The frequency of apoE4 was 31 % in HCG and only 10 % in LCG. The frequency of apoE4+ genotypes was not significantly different between tertilles based on birth weight in HCG. We suppose that intrauterine undernutrition, demonstrated by a lower birth weight, participates in the development of hypercholesterolemia already in childhood. The effects of low birth weight and the candidate gene - apoE, are synergic.

Association of adipokines with cardiovascular risk factors in low birth weight children: a case–control study

2012 ◽  
Vol 172 (1) ◽  
pp. 71-76 ◽  
Author(s):  
Maria Wany Louzada Strufaldi ◽  
Rosana Fiorini Puccini ◽  
Olga Maria Amâncio Silvério ◽  
Maria Carmo do Pinho Franco
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Cardiovascular Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Low Birth Weight Children ◽  
Control Study

scholarly journals No Association between Low Birth Weight and Cardiovascular Risk Factors in Early Adulthood: Evidence from São Paulo, Brazil

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66554 ◽  
Author(s):  
Filumena Maria Gomes ◽  
S. V. Subramanian ◽  
Ana Maria de Ulhôa Escobar ◽  
Maria Helena Valente ◽  
Sandra Josefina Ferraz Ellero Grisi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Cardiovascular Risk Factors ◽  
Early Adulthood ◽  
Sao Paulo ◽  
São Paulo

scholarly journals Impact of Low Birth Weight and Cardiovascular Risk Factors on Endothelial Function in Early Adult Life

Circulation ◽  
2001 ◽  
Vol 103 (9) ◽  
pp. 1264-1268 ◽  
Author(s):  
C. P. M. Leeson ◽  
M. Kattenhorn ◽  
R. Morley ◽  
A. Lucas ◽  
J. E. Deanfield
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Endothelial Function ◽  
Cardiovascular Risk Factors ◽  
Adult Life ◽  
Early Adult Life

Risk factors for low birth weight in a rural community in southern Brazil

1996 ◽  
Vol 72 (6) ◽  
pp. 369-373 ◽  
Author(s):  
Ricardo Halpern ◽  
Earl S. Schaefer ◽  
Airton S. Pereira ◽  
Ernesto M. Arnt ◽  
Jandira Pureza Valente Bezerra ◽  
...  
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Rural Community ◽  
Southern Brazil

scholarly journals Intraventricular haemorrhage in a Ugandan cohort of low birth weight neonates: the IVHU study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
R. MacLeod ◽  
J. N. Paulson ◽  
N. Okalany ◽  
F. Okello ◽  
L. Acom ◽  
...  
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Intraventricular Haemorrhage ◽  
Sub Saharan Africa ◽  
Cranial Ultrasound ◽  
High Grade ◽  
Odds Ratios ◽  
Antenatal Steroids ◽  
Eastern Uganda

Abstract Background Globally, 15 million neonates are born prematurely every year, over half in low income countries (LICs). Premature and low birth weight neonates have a higher risk of intraventricular haemorrhage (IVH). There are minimal data regarding IVH in sub-Saharan Africa. This study aimed to examine the incidence, severity and timing of and modifiable risk factors for IVH amongst low-birth-weight neonates in Uganda. Methods This is a prospective cohort study of neonates with birthweights of ≤2000 g admitted to a neonatal unit (NU) in a regional referral hospital in eastern Uganda. Maternal data were collected from interviews and medical records. Neonates had cranial ultrasound (cUS) scans on the day of recruitment and days 3, 7 and 28 after birth. Risk factors were tabulated and are presented alongside odds ratios (ORs) and adjusted odds ratios (aORs) for IVH incidence. Outcomes included incidence, timing and severity of IVH and 28-day survival. Results Overall, 120 neonates were recruited. IVH was reported in 34.2% of neonates; 19.2% had low grade (Papile grades 1–2) and 15% had high grade (Papile grades 3–4). Almost all IVH (90.2%) occurred by day 7, including 88.9% of high grade IVH. Of those with known outcomes, 70.4% (81/115) were alive on day 28 and survival was not associated with IVH. We found that vaginal delivery, gestational age (GA) < 32 weeks and resuscitation in the NU increased the odds of IVH. Of the 6 neonates who received 2 doses of antenatal steroids, none had IVH. Conclusion In this resource limited NU in eastern Uganda, more than a third of neonates born weighing ≤2000 g had an IVH and the majority of these occurred by day 7. We found that vaginal birth, earlier gestation and need for resuscitation after admission to the NU increased the risk of IVH. This study had a high rate of SGA neonates and the risk factors and relationship of these factors with IVH in this setting needs further investigation. The role of antenatal steroids in the prevention of IVH in LICs also needs urgent exploration.

Prevalence, Risk Factors, and Short-Term Outcomes of Full-Term Low Birth Weight Infants Born at a Tertiary Academic Center: A Prospective Case–Control Study

2021 ◽  
Author(s):  
Heidi K. Al-Wassia ◽  
Shahd K. Baarimah ◽  
Asmaa H. Mohammedsaleh ◽  
Manal O. Alsulami ◽  
Ragad S. Abbas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Case Control Study ◽  
Case Control ◽  
Adverse Outcomes ◽  
Chromosomal Anomalies ◽  
Short Term ◽  
Term Infants ◽  
Control Study

Objective Low birth weight (LBW) infants (<2,500 g) continued to be a global health problem because of the associated short- and long-term adverse outcomes. The study aimed to determine the prevalence, risk factors, and short-term outcomes of term LBW infants Study Design A prospective and case–control study. All infants born consecutively from September 1, 2018 to August 31, 2019 were included. Cases, term LBW infants, were 1:1 matched to controls, appropriate for gestational age (AGA) term infants. Major congenital or chromosomal anomalies and multiple pregnancies were excluded. Results The prevalence of term LBW in the studied period was 4.8%. Mothers of term LBW infants had significantly lower body mass index (p = 0.05), gained less weight (p = 0.01), had a history of previous LBW (p = 0.01), and lower monthly income (p = 0.04) compared with mothers of term AGA infants even after adjustment for confounders. A nonsignificant higher number of term LBW infants needed NICU admission, while their need for phototherapy was deemed significant. Conclusion We identified nutritional and socioeconomic maternal factors that are significantly associated with LBW infants and should be targeted during antenatal visits to improve neonatal outcomes. Key Points

scholarly journals Frequency, risk factors and materno-foetal outcomes among cases of Placenta previa at a tertiary care hospital: a two year study

2019 ◽  
Vol 8 (6) ◽  
pp. 2240
Author(s):  
Pamulaparthi Bindu Reddy ◽  
Gurram Swetha Reddy
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Tertiary Care Hospital ◽  
Placenta Previa ◽  
Tertiary Care ◽  
Previous History ◽  
Morbidity And Mortality ◽  
Care Hospital ◽  
Early Date

Background: Placenta previa refers to the presence of placental tissue that extends over the internal cervical os.  Placenta previa is linked to maternal hypovolemia, anaemia, and long hospital stay and with prematurity, low birth weight, low APGAR score in newborn. So it is very important to identify the condition at an early date to warn the condition thereby reducing the maternal and foetal morbidity and mortality. The present study was aimed to estimate the prevalence of PP, its associated predisposing risk factors and maternal morbidity, mortality and the perinatal outcome.Methods: A prospective observational study for two years was conducted at a tertiary care hospital. Pregnant mothers with >28 weeks of age with H/o ante partum haemorrhage were screened for placenta previa, confirmed by ultra sonography and included in the study. Clinical history, obstetric examination was done and followed up till the delivery. Maternal and foetal outcomes were recorded. Data analyzed by using SPSS version 20.Results: 1.4% incidence of PP was noted, mean age of group was 29.17±1.6 years. Age group of 21-30 years, multiparity Gravida 2-4, previous history of caesarean section and less number of ante natal checkups were significant risk factors and LSCS was most common outcome. Prematurity, low birth weight and APGAR <7 score for 1 minute was common foetal outcomes.Conclusions: Our study strongly suggests foetal surveillance programmes in cases of placenta previa. Measures should be made to bring awareness about PP, in urban slums and to increase medical checkups regularly. Making USG mandatory during every ANC and referral of cases of PP to tertiary care centres would definitely reduce the chances of morbidity and mortality.

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