scholarly journals Erythrocyte omega-3, omega-6 and trans fatty acids in relation to risk of preeclampsia among women delivering at harare maternity hospital, Zimbabwe

2007 ◽  
pp. 37-50
Author(s):  
K Mahomed ◽  
MA Williams ◽  
IB King ◽  
S Mudzamiri ◽  
GB Woelk
Keyword(s):  
Fatty Acids ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Trans Fatty Acids ◽  
Positive Association ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Omega 6 ◽  
3 Omega ◽  
Risk Of Preeclampsia

We sought to examine the association between maternal erythrocyte omega-3, omega-6 and trans fatty acids and risk of preeclampsia. We conducted a case-control study of 170 women with proteinuric, pregnancy-induced hypertension and 185 normotensive pregnant women who delivered at Harare Maternity Hospital, Harare, Zimbabwe. We measured erythrocyte omega-3, omega-6 and trans fatty acid as the percentage of total fatty acids using gas chromatography. After multivariate adjustment for confounding factors, women in the highest quartile group for total omega-3 fatty acids compared with women in the lowest quartile experienced a 14% reduction in risk of preeclampsia (odds ratio 0.86, 95% confidence interval 0.45 to 1.63). For total omega-6 fatty acids the odds ratio was 0.46 (95% confidence interval 0.23 to 0.92), although there was suggestion of a slight increase in risk of preeclampsia associated with high levels of arachidonic acid. Among women in the highest quartile for arachidonic acid the odds ratio was 1.29 (95% confidence interval 0.66 to 2.54). A strong statistically significant positive association of diunsaturated fatty acids with a trans double bond with risk of preeclampsia was observed. Women in the upper quartile of 9-cis 12-trans octadecanoic acid (C(18:2n6ct)) compared with those in the lowest quartile experienced a 3-fold higher risk of preeclampsia (odds ratio = 3.02, 95% confidence interval 1.41 to 6.45). Among women in the highest quartile for 9-trans 12-cis octadecanoic acid (C(18:2n6tc)) the odds ratio was 3.32 (95% confidence interval 1.55 to 7.13). Monounsaturated trans fatty acids were also positively associated with the risk of preeclampsia, although of much reduced magnitude. We observed a strong positive association of trans fatty acids, particularly diunsaturated trans fatty acids, with the risk of preeclampsia. We found little support for the hypothesized inverse association between omega-3 fatty acids and preeclampsia risk in this population. Polyunsaturated fatty acids, particularly omega-3 fatty acids, were comparatively lower in Zimbabwean than among US pregnant women. Given the limited inter-person variation in omega-3 fatty acids among Zimbabwean women, our sample size may be too small to adequately assess the relation in this population.

scholarly journals IDENTIFIKASI ASAM LEMAK OMEGA PADA ASI EKSKLUSIF MENGGUNAKAN KROMATOGRAFI GC-MS

2017 ◽  
Vol 1 (1) ◽  
pp. 1-7
Author(s):  
Titin Aryani ◽  
Fitria Siswi Utami ◽  
Sulistyaningsih Sulistyaningsih
Keyword(s):  
Fatty Acids ◽  
Breast Milk ◽  
Quantitative Research ◽  
Gas Chromatography Mass Spectrometry ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Omega Fatty Acids ◽  
Omega 3 Fatty Acid ◽  
Omega 6 ◽  
3 Omega

Abstract: Quantitative research aims to identify the omega fatty acids in exclusive breast milk (ASI) Exclusive. The data analysis used data chromatogram Gas Chromatography-Mass Spectrometry (GC-MS). The data generated is breast milk (ASI) had higher levels of omega-3 fatty acids amounting to 28.24%, omega-6 and omega of 0.57% 9 at 26.56%. The conclusion from this study is there is the content of omega-3, omega-6, omega-9 fatty acids in breast milk (ASI). Highest levels of omega fatty acids in breast milk is the omega-3 fatty acid that is equal to 28.24%.Keywords: milk, omega fatty acids, GC-MS

scholarly journals Pre-pregnancy Dietary Intake of Omega-3 and Omega-6 Fatty Acids and the Risk of Hypertensive Disorders of Pregnancy

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 709-709
Author(s):  
Mariel Arvizu ◽  
Lidia Minguez-Alarcon ◽  
Jennifer Stuart ◽  
Makiko Mitsunami ◽  
Janet Rich-Edwards ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Dietary Intake ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Increased Risk ◽  
Omega 6 ◽  
One Year ◽  
Long Chain ◽  
Risk Of Preeclampsia

Abstract Objectives To evaluate whether pre-pregnancy intakes of omega-3 and omega-6 fatty acids prevent HDP. Methods We followed 11,535 women from the Nurses' Health Study-II free of chronic disease that filled out food frequency questionnaires starting in 1991 before their 16,892 singleton pregnancies. Intakes of omega-3 fatty acids (alpha-linolenic acid[ALA] + long-chain omega-3 [LCN-3]) and omega-6 (linoleic acid [LA] + arachidonic acid[ARA]). In 2009, participants reported history of preeclampsia and GHTN. The relative risk (95%CI) of HDP across quintiles of intakes of omega-3 and omega-6 were estimated by log-binomial regression model using generalized estimating equation to account for repeated pregnancies from the same woman and adjusted for age at pregnancy, year of pregnancy, and pre-pregnancy: BMI, physical activity, smoking, infertility diagnosis, marital status, race, parity, multivitamin use, concurrent gestational diabetes, and preeclampsia at baseline. Results During 18 years of follow-up, there were 495 pregnancies with preeclampsia (2.9%) and 561 pregnancies (3.3%) with GHTN. Mean (SD) age at pregnancy was 34.6 (3.9) years. Intakes of total omega-6 and total omega-3 fatty acids before pregnancy were unrelated with the risk of either HDP. From individual omega subtypes, only ARA had a marginally significant relation to higher risk of GHTN. Women in the highest quintile of ARA had 43% increased risk of GHTN (CI: 1.00–2.04) compared to women in the lowest quintile of intake. Intakes of the remaining subtypes, LA, LCN-3, and ALA were not associated to HDP risk. When we restricted the analysis to a closer window of exposure among 5,208 women with diet assessment one year before pregnancy, only intakes of LCN-3 (RR = 0.55, CI:0.33–0.91) and LA (RR = 0.54, CI: 0.29,0.99) were associated with a lower risk of preeclampsia, comparing women in the highest versus the lowest quintile of intake. Conclusions Dietary intake of long-chain omega-3 fatty acid and linoleic acid one year before pregnancy was associated with a reduced risk of preeclampsia. The extent to which long-chain omega-3 prevents preeclampsia may be more relevant in a window of exposure closer to pregnancy. Funding Sources National Institutes of Health grants U01-HL145386–01, UM1-CA176726, P30-DK046200, and R00ES026648.

scholarly journals Significance of Trans Fatty Acids and Omega-3 Fatty Acids in Japanese Men with Coronary Heart Disease

2020 ◽  
Author(s):  
Shinji Koba ◽  
Tetsuya Takao ◽  
Fumiko Shimizu ◽  
Mutsumi Ogawa ◽  
Yuuya Yokota ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Trans Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Japanese Men

scholarly journals PENGARUH PADAT TEBAR TERHADAP KANDUNGAN ZAT GIZI IKAN LELE YANG DIPELIHARA DENGAN TEKNOLOGI BIOFLOK

2019 ◽  
Vol 20 (2) ◽  
pp. 120-131
Author(s):  
Settings Anang Suhardianto ◽  
Ariyanti Hartari
Keyword(s):  
Fatty Acids ◽  
Confidence Interval ◽  
Water Content ◽  
Unsaturated Fatty Acids ◽  
Statistical Tests ◽  
Stocking Density ◽  
Nutrient Content ◽  
Omega 3 ◽  
Omega 6 ◽  
Total Fat

This study aims to determine the effect of stocking density on the nutrient content of catfish that is maintained with biofloc technology. Nutrients observed: 1) water content, 2) protein, 3) carbohydrates, 4) total fat, 5) saturated fatty acids / SFA, 6) monounsaturated fatty acids/ MUFA, 7) plural unsaturated fatty acids / PUFA , 8) omega-3, 9) omega-6, and 10) omega 9. Statistical tests on the 10 variables showed that stocking density did not have a significant effect on the 10 variables at a 5% confidence interval. Stocking density of treatment is 1000 heads/pond (T1), 2000 heads/pond (T2), 3000 heads/pond (T3), with a pond size of 2.0 m x height 1.0 m. Research results: 1. The average water content is 69.40–71.47% and the highest T3. 2. The protein content is 14.70-15.90%, the highest T2. 3. Carbohydrate content of 5.16-5.50%, the highest T2. 4. The average total fat content of 6.73-7.78%, the highest T1. 5. SFA content is around 43%, PUFA around 23%, and MUFA around 32%. 6. The highest omega-3 content is T3, then T1, and T2. Omega-6 and 9 sequence contents are T1, T2, and T3. It was concluded, the treatment of biofloc catfish stocking densities at a 5% confidence interval did not have a significant effect on the specified nutrient content. Penelitian ini bertujuan untuk menentukan pengaruh padat tebar terhadap kandungan zat gizi ikan lele yang dipelihara dengan teknologi bioflok. Zat gizi yang diamati: 1) kandungan air, 2) protein, 3) karbohidrat, 4) lemak total, 5) asam lemak jenuh/SFA, 6) asam lemak tak jenuh tunggal/MUFA, 7) asam lemak tak jenuh jamak/PUFA, 8) omega-3, 9) omega 6, dan 10) omega 9. Uji statistik terhadap ke-10 variabel menunjukkan padat tebar tidak memberikan pengaruh nyata terhadap ke-10 variabel pada selang kepercayaan 5%.  Padat tebar perlakuan adalah 1000 ekor/kolam (T1),  2000 ekor/kolam (T2), 3000 ekor/kolam (T3), dengan ukuran kolam diameter 2,0 m x tinggi 1,0 m. Hasil penelitian: 1. Rata-rata kandungan air 69,40–71,47% dan T3 tertinggi. 2. Kandungan protein 14,70–15,90%, T2 tertinggi. 3. Kandungan karbohidrat 5,16–5,50%, T2 tertinggi. 4. Rata-rata kandungan lemak total 6,73–7,98%, T1 tertinggi. 5. Kandungan SFA sekitar 43%, PUFA sekitar 23%, dan MUFA sekitar 32%. 6. Kandungan omega-3 tertinggi T3, kemudian T1, dan T2. Omega-6 dan 9 urutan kandungannya T1, T2, dan T3.  Disimpulkan, perlakuan padat tebar lele bioflok pada selang kepercayaan 5% tidak memberikan pengaruh yang nyata terhadap kandungan zat gizi yang ditentukan.

scholarly journals 139 Nutrigenetics/Nutrigenomics: Nutrient-gene interactions in humans and animals

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 134-135
Author(s):  
Artemis P Simopoulos
Keyword(s):  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Genetic Variants ◽  
Genetic Variant ◽  
Fatty Acid Desaturase ◽  
Omega 3 Fatty Acids ◽  
Human Beings ◽  
Omega 3 ◽  
Omega 6

Abstract Human beings evolved on a diet that was balanced in the omega-6 and omega-3 essential fatty acids to which their genes were programmed to respond. Studies on gene-nutrient interactions using methods from molecular biology and genetics have clearly shown that there are genetic differences in the population, as well as differences in the frequency of genetic variations that interact with diet and influence the growth and development of humans and animals, as well as overall health and chronic disease. Nutrigenetics refers to studies on the role of genetic variants and their response to diet. For example, persons with genetic variants in the metabolism of omega-6 and omega-3 fatty acids have different levels of arachidonic acid (AA) and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) based on the type of genetic variant in the Fatty Acid Desaturase 1 (FADS1) and Fatty Acid Desaturase 2 (FADS2). At the same level of linoleic acid (LA) and alpha-linolenic acid (ALA) a person with a genetic variant that increases the activity of the FADS1 will have a higher AA in the red cell membrane phospholipids and a higher risk for obesity and cardiovascular disease. Nutrigenomics refers to how nutrients (diets) influence the expression of genes. For example, diets rich in omega-3 fatty acids, EPA and DHA decrease the expression of inflammatory genes and as a result decrease the risk of obesity and cardiovascular disease. Thus, through studies on Nutrigenetics/Nutrigenomics nutritional science stands at its “golden threshold” where personalized nutrition is the future, to improve an individual’s health.

scholarly journals PSV-39 Fatty acids profile of the meat from Nellore young bulls supplemented with lauric acid

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 339-340
Author(s):  
Sergiane A Araújo ◽  
Ronaldo L Oliveira ◽  
Analívia M Barbosa ◽  
Aline R Silva ◽  
Rebeca D X Ribeiro ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lauric Acid ◽  
Saturated Fatty Acids ◽  
Monounsaturated Fatty Acids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Fatty Acids Profile ◽  
Coronary Diseases ◽  
Total Diet ◽  
Omega 6

Abstract Lauric acid (LA) is an additive used in ruminant’s diet with the purpose of mitigating the methane effect. However, the presence of a certain amount of LA in the rumen can cause a reduction in the microbial population and ruminal metabolic processes, such as the biohydrogenation. This study aimed evaluate the effect of the LA inclusion in the diet of Nellore on the fatty acids profile of the meat. Thirty-two young Nellore bulls were used with an average age of 24-months. The animals were individually fed with a total mixed ration with 40% of roughage (Cynodon sp. hay) and 60% of concentrated mix, composed with ground corn, soybean meal, urea, mineral premix and LA in 0.0; 0.5; 1.0; 1.5% of inclusion in the total diet dry matter basis. Those amounts constituted the treatments. At the end of the trial, the animals were slaughtered and the meat was stored at -21oC, before analyses. The experimental design was completely randomized, with four treatments and eight replications. The data were submitted to regression analysis, and significance was declared when P < 0.05. There was no effect (P > 0.05) of the inclusion of LA in the sum of saturated fatty acids (∑SAF=43.45±1.55), monounsaturated fatty acids (∑MUFA=41.9±0.29), and polyunsaturated fatty acids (∑PUFA=12.25±1.40). The inclusion of LA in the diets also did not affect the sum of omega-3 fatty acids (∑ n-3=1.05±0.22), omega-6 fatty acids (∑ n-6=3.02±0.49, and the reason n-6: n-3 (2.91±0.12). The atherogenicity (0.65±0.05) and trombogenicity (1.47±0.10) indexes, important indexes to predict heart coronary diseases risk, were not affected by the inclusion of LA in the diet of the animals. The results suggest that LA can be included up to 1.5% (DM basis of total diet) in the diets of Nellore without causing any significant changes in the fatty acids profile of the meat.

Sign in / Sign up

Export Citation Format

Share Document