scholarly journals Vascularization of Diabetes-reversing Implants: Development of Sustained Release Formulations of Proangiogenic Growth Factors

10.33540/309 ◽  
2020 ◽  
Author(s):  
◽  
Karina Christiane Scheiner
Keyword(s):  
Growth Factors ◽  
Sustained Release

Collagen fibrous scaffolds for sustained delivery of growth factors for meniscal tissue engineering

Nanomedicine ◽  
2022 ◽  
Author(s):  
Jihye Baek ◽  
Kwang Il Lee ◽  
Ho Jong Ra ◽  
Martin K Lotz ◽  
Darryl D D'Lima
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Sustained Release ◽  
Ex Vivo ◽  
Synovial Cell ◽  
Growth Factor Delivery ◽  
Meniscal Tissue ◽  
A Cell

Aim: To mimic the ultrastructural morphology of the meniscus with nanofiber scaffolds coupled with controlled growth factor delivery to modulate cellular performance for tissue engineering of menisci. Methods: The authors functionalized collagen nanofibers by conjugating heparin to the following growth factors for sustained release: PDGF-BB, TGF-β1 and CTGF. Results: Incorporating growth factors increased human meniscal and synovial cell viability, proliferation and infiltration in vitro, ex vivo and in vivo; upregulated key genes involved in meniscal extracellular matrix synthesis; and enhanced generation of meniscus-like tissue. Conclusion: The authors' results indicate that functionalizing collagen nanofibers can create a cell-favorable micro- and nanoenvironment and can serve as a system for sustained release of bioactive factors.

Highly Aligned Electrospun Collagen/Polycaprolactone Surgical Sutures with Sustained Release of Growth Factors for Wound Regeneration

2020 ◽  
Vol 3 (2) ◽  
pp. 965-976 ◽  
Author(s):  
Jinyu Hu ◽  
Yi Song ◽  
Cuiyun Zhang ◽  
Wen Huang ◽  
Anqi Chen ◽  
...  
Keyword(s):  
Growth Factors ◽  
Sustained Release ◽  
Surgical Sutures

Release of Growth Factors from Gelatin Microsphere/CaP Composites

2007 ◽  
Vol 361-363 ◽  
pp. 527-530 ◽  
Author(s):  
W.J.E.M. Habraken ◽  
O.C. Boerman ◽  
Joop G.C. Wolke ◽  
Antonious G. Mikos ◽  
John A. Jansen
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Sustained Release ◽  
In Vitro Release ◽  
Gelatin Microspheres ◽  
Or Efficiency ◽  
Loading Method ◽  
Gelatin Microsphere ◽  
Release Curve

Composites of gelatin microspheres and injectable calcium phosphate cement were prepared to increase cement resorption and improve tissue ingrowth. To further enhance these properties, osteoinductive growth factors can be introduced into the microspheres. In this study, the in vitro release of preset gelatin microsphere/CaP composites was followed for 6 weeks by use of 125I-labelled rhBMP-2, rhTGF-β and rh-bFGF. Results for all gelatin microsphere composites showed a release curve that consisted of a small burst, followed by a sustained release. The magnitude of the sustained release was dependent on the growth factor used, and showed a slight dependency on the loading method and type of gelatin. Furthermore, no differences in release pattern or efficiency were found when growth factor concentration increased.

scholarly journals Surgical Sutures with Porous Sheaths for the Sustained Release of Growth Factors

2016 ◽  
Vol 28 (23) ◽  
pp. 4620-4624 ◽  
Author(s):  
Jianhua Li ◽  
Stephen W. Linderman ◽  
Chunlei Zhu ◽  
Hong Liu ◽  
Stavros Thomopoulos ◽  
...  
Keyword(s):  
Growth Factors ◽  
Sustained Release ◽  
Surgical Sutures

Sustained release of growth factors from photoactivated platelet rich plasma (PRP)

2020 ◽  
Vol 148 ◽  
pp. 67-76 ◽  
Author(s):  
Gülseren Irmak ◽  
Tuğrul Tolga Demirtaş ◽  
Menemşe Gümüşderelioğlu
Keyword(s):  
Growth Factors ◽  
Sustained Release ◽  
Platelet Rich Plasma

scholarly journals Heparin-Modified Amniotic Membrane Combined With Growth Factors for Promoting Corneal Wound Healing After Alkali Burn

2020 ◽  
Vol 8 ◽  
Author(s):  
Xuan Zhao ◽  
Xin Zuo ◽  
Jing Zhong ◽  
Bowen Wang ◽  
Saiqun Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Sustained Release ◽  
Corneal Epithelial Cell ◽  
Control Group ◽  
Therapeutic Effects ◽  
Cell Growth And Migration ◽  
Corneal Epithelial

Ocular chemical burns are potentially blinding ocular injuries and require urgent management. Amniotic membrane (AM) transplantation is an effective surgical treatment, one of the reasons is because AM is a rich source of growth factors that can promote epithelialization and wound healing. However, growth factors will be gradually lost and insufficient after preparation process and long-time storage, leading to unsatisfactory therapeutic effects. Herein, we present a modified AM (AM-HEP) for the supplement and sustained release of growth factor by surface grafting heparin for treatment of ocular chemical burns. Heparin grafting rate and stability, microstructure, physical property, and sustained release of epithelial growth factor (EGF) of AM-HEP were characterized. Biocompatibility and ability to promote corneal epithelial cell growth and migration were evaluated and compared with a biological amnion, which is available on the market in vitro. The therapeutic effects of AM-HEP combined with EGF (AM-HEP@EGF) in vivo had been evaluated in a model of mouse corneal alkali burn. The results indicated that heparin was introduced into AM and maintain stability over 3 weeks at 37°C. The modification process of AM-HEP did not affect microstructure and physical property after comparing with non-modified AM. EGF could be combined quickly and effectively with AM-HEP; the sustained release could last for more than 14 days. AM-HEP@EGF could significantly promote corneal epithelial cell growth and migration, compared with non-modified AM and control group. Faster corneal epithelialization was observed with the transplantation of AM-HEP@EGF in vivo, compared with the untreated control group. The corneas in the AM-HEP@EGF group have less inflammation and were more transparent than those in the control group. The results from in vitro and in vivo experiments demonstrated that AM-HEP@EGF could significantly enhance the therapeutic effects. Taken together, AM-HEP@EGF is exhibited to be a potent clinical application in corneal alkali burns through accelerating corneal epithelial wound healing.

scholarly journals Ultrahigh protein adsorption capacity and sustained release of nanocomposite scaffolds: implication for growth factor delivery systems

RSC Advances ◽  
2017 ◽  
Vol 7 (27) ◽  
pp. 16453-16459 ◽  
Author(s):  
Ji-Young Yoon ◽  
Jung-Ju Kim ◽  
Ahmed El-Fiqi ◽  
Jun-Hyeog Jang ◽  
Hae-Won Kim
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Sustained Release ◽  
Protein Adsorption ◽  
Adsorption Capacity ◽  
Delivery Systems ◽  
Growth Factor Delivery ◽  
Load Growth ◽  
Nanocomposite Scaffolds

Nanocomposite scaffolds that can load growth factors effectively and release them sustainably are developed for the regeneration of tissues.

scholarly journals Research Advances in Tissue Engineering Materials for Sustained Release of Growth Factors

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Hai-yang Zhao ◽  
Jiang Wu ◽  
Jing-jing Zhu ◽  
Ze-cong Xiao ◽  
Chao-chao He ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Sustained Release ◽  
Enzymatic Degradation ◽  
Bone Repair ◽  
Sustained Delivery ◽  
System Disease ◽  
Free Growth ◽  
Intense Research

Growth factors are a class of cytokines that stimulate cell growth and are widely used in clinical practice, such as wound healing, revascularization, bone repair, and nervous system disease. However, free growth factors have a short half-life and are instablein vivo. Therefore, the search of excellent carriers to enhance sustained release of growth factorsin vivohas become an area of intense research interest. The development of controlled-release systems that protect the recombinant growth factors from enzymatic degradation and provide sustained delivery at the injury site during healing should enhance the growth factor’s application in tissue regeneration. Thus, this study reviews current research on commonly used carriers for sustained release of growth factors and their sustained release effects for preservation of their bioactivity and their accomplishment in tissue engineering approaches.

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