Molecular imaging in oncology: Current impact and future directions

Molecular imaging is revolutionizing the way we study the inner workings of the human body, diagnose diseases, approach drug design, and assess therapies. The field as a whole is making possible the visualization of complex biochemical processes involved in normal physiology and disease states, in real time, in living cells, tissues, and intact subjects. In this review, we focus specifically on molecular imaging of intact living subjects. We provide a basic primer for those who are new to molecular imaging, and a resource for those involved in the field. We begin by describing classical molecular imaging techniques together with their key strengths and limitations, after which we introduce some of the latest emerging imaging modalities. We provide an overview of the main classes of molecular imaging agents (i.e., small molecules, peptides, aptamers, engineered proteins, and nanoparticles) and cite examples of how molecular imaging is being applied in oncology, neuroscience, cardiology, gene therapy, cell tracking, and theranostics (therapy combined with diagnostics). A step-by-step guide to answering biological and/or clinical questions using the tools of molecular imaging is also provided. We conclude by discussing the grand challenges of the field, its future directions, and enormous potential for further impacting how we approach research and medicine.

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Water sustainability: future directions

Microbiology Australia ◽

10.1071/ma09004 ◽

2009 ◽

Vol 30 (1) ◽

pp. 4

Author(s):

Simon Toze

Keyword(s):

Global Warming ◽

Human Activity ◽

Water Usage ◽

Water Sustainability ◽

Future Directions ◽

Australian Community ◽

Rainfall Patterns ◽

Current Impact

Water sustainability: future directions Whether you?re a believer or a sceptic about global warming and the influence of human activity on the climate, there is little argument about the current impact of drought and changing rainfall patterns on Australia. The Australian community is coming to grips with the fact that we need to be cleverer on how we use water. This has resulted in a significant increase in interest about water sustainability and has increased demands on governments at all levels to improve water usage and efficiency.

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Molecular imaging of fibrosis: recent advances and future directions

Journal of Clinical Investigation ◽

10.1172/jci122132 ◽

2019 ◽

Vol 129 (1) ◽

pp. 24-33 ◽

Cited By ~ 27

Author(s):

Sydney B. Montesi ◽

Pauline Désogère ◽

Bryan C. Fuchs ◽

Peter Caravan

Keyword(s):

Molecular Imaging ◽

Future Directions ◽

Recent Advances

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Smart molecules for imaging, sensing and health (SMITH)

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.11.274 ◽

2015 ◽

Vol 11 ◽

pp. 2540-2548 ◽

Cited By ~ 9

Author(s):

Bradley D Smith

Keyword(s):

Molecular Imaging ◽

Membrane Transport ◽

Supramolecular Chemistry ◽

Ion Pair ◽

Personal Account ◽

Future Directions ◽

Squaraine Rotaxanes

This autobiographical review provides a personal account of the author’s academic journey in supramolecular chemistry, including brief summaries of research efforts in membrane transport, molecular imaging, ion-pair receptors, rotaxane synthesis, squaraine rotaxanes, and synthtavidin technology. The article concludes with a short perspective of likely future directions in biomedical supramolecular chemistry.

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