47. Evaluation of the Dermal Absorption of Toluene in F344 Rats Using Real-Time Breath Analysis and PBPK Modeling

2002 ◽  
Author(s):  
K. Thrall ◽  
A. Woodstock
Keyword(s):  
Real Time ◽  
Breath Analysis ◽  
Dermal Absorption ◽  
Pbpk Modeling ◽  
F344 Rats

scholarly journals Real Time Breath Analysis Using Portable Gas Chromatography for Adult Asthma Phenotypes

Metabolites ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 265
Author(s):  
Ruchi Sharma ◽  
Wenzhe Zang ◽  
Menglian Zhou ◽  
Nicole Schafer ◽  
Lesa A. Begley ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Real Time ◽  
Rapid Assessment ◽  
Principal Component ◽  
Corticosteroid Treatment ◽  
Breath Analysis ◽  
Blood Eosinophil ◽  
Exhaled Breath ◽  
Respiratory Illnesses ◽  
Linear Discriminant

Asthma is heterogeneous but accessible biomarkers to distinguish relevant phenotypes remain lacking, particularly in non-Type 2 (T2)-high asthma. Moreover, common clinical characteristics in both T2-high and T2-low asthma (e.g., atopy, obesity, inhaled steroid use) may confound interpretation of putative biomarkers and of underlying biology. This study aimed to identify volatile organic compounds (VOCs) in exhaled breath that distinguish not only asthmatic and non-asthmatic subjects, but also atopic non-asthmatic controls and also by variables that reflect clinical differences among asthmatic adults. A total of 73 participants (30 asthma, eight atopic non-asthma, and 35 non-asthma/non-atopic subjects) were recruited for this pilot study. A total of 79 breath samples were analyzed in real-time using an automated portable gas chromatography (GC) device developed in-house. GC-mass spectrometry was also used to identify the VOCs in breath. Machine learning, linear discriminant analysis, and principal component analysis were used to identify the biomarkers. Our results show that the portable GC was able to complete breath analysis in 30 min. A set of nine biomarkers distinguished asthma and non-asthma/non-atopic subjects, while sets of two and of four biomarkers, respectively, further distinguished asthmatic from atopic controls, and between atopic and non-atopic controls. Additional unique biomarkers were identified that discriminate subjects by blood eosinophil levels, obese status, inhaled corticosteroid treatment, and also acute upper respiratory illnesses within asthmatic groups. Our work demonstrates that breath VOC profiling can be a clinically accessible tool for asthma diagnosis and phenotyping. A portable GC system is a viable option for rapid assessment in asthma.

Real Time Mental Stress Detection Through Breath Analysis

2020 ◽  
pp. 403-410
Author(s):  
Paulo Santos ◽  
Peter Roth ◽  
Jorge M. Fernandes ◽  
Viktor Fetter ◽  
Valentina Vassilenko
Keyword(s):  
Real Time ◽  
Mental Stress ◽  
Breath Analysis ◽  
Stress Detection

Real Time Breath Analysis of Multiple Markers of Respiratory Disease.

2009 ◽  
Author(s):  
JH Shorter ◽  
DD Nelson ◽  
MS Zahniser ◽  
JB McManus ◽  
DK Milton ◽  
...  
Keyword(s):  
Real Time ◽  
Respiratory Disease ◽  
Breath Analysis ◽  
Multiple Markers

scholarly journals Breath Analysis in Real Time by Mass Spectrometry in Chronic Obstructive Pulmonary Disease

Respiration ◽  
2014 ◽  
Vol 87 (4) ◽  
pp. 301-310 ◽  
Author(s):  
Pablo Martinez-Lozano Sinues ◽  
Lukas Meier ◽  
Christian Berchtold ◽  
Mark Ivanov ◽  
Noriane Sievi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Chronic Obstructive Pulmonary Disease ◽  
Real Time ◽  
Pulmonary Disease ◽  
Breath Analysis ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease
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