scholarly journals Breath Analysis in Real Time by Mass Spectrometry in Chronic Obstructive Pulmonary Disease

Respiration ◽  
2014 ◽  
Vol 87 (4) ◽  
pp. 301-310 ◽  
Author(s):  
Pablo Martinez-Lozano Sinues ◽  
Lukas Meier ◽  
Christian Berchtold ◽  
Mark Ivanov ◽  
Noriane Sievi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Chronic Obstructive Pulmonary Disease ◽  
Real Time ◽  
Pulmonary Disease ◽  
Breath Analysis ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Proteome of a Moraxella catarrhalis Strain under Iron-Restricted Conditions

2020 ◽  
Vol 9 (12) ◽  
Author(s):  
Luke V. Blakeway ◽  
Aimee Tan ◽  
Ian R. Peak ◽  
John M. Atack ◽  
Kate L. Seib
Keyword(s):  
Mass Spectrometry ◽  
Chronic Obstructive Pulmonary Disease ◽  
Differential Expression ◽  
Pulmonary Disease ◽  
Moraxella Catarrhalis ◽  
Chronic Obstructive ◽  
Iron Starvation ◽  
Data Set ◽  
Obstructive Pulmonary Disease ◽  
Content Type

Moraxella catarrhalis is a leading cause of otitis media and exacerbations of chronic obstructive pulmonary disease; however, its response to iron starvation during infection is not completely understood. Here, we announce a sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) data set describing the differential expression of the M. catarrhalis CCRI-195ME proteome under iron-restricted versus iron-replete conditions.

scholarly journals Hemoglobin Rambam (β69[E13]Gly→Asp), a pitfall in the assessment of diabetic control: characterization by electrospray mass spectrometry and HPLC

1998 ◽  
Vol 44 (10) ◽  
pp. 2172-2177 ◽  
Author(s):  
E Bissé ◽  
N Zorn ◽  
A Eigel ◽  
M Lizama ◽  
P Huaman-Guillen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Electrospray Mass Spectrometry ◽  
Clinical Symptoms ◽  
Dependent Diabetes Mellitus ◽  
Chronic Obstructive ◽  
Diabetic Patients ◽  
Obstructive Pulmonary Disease ◽  
Hb A1c

Abstract Hemoglobin (Hb) Rambam, or β69[E13]Gly→Asp, has been identified in a German woman also suffering from non-insulin-dependent diabetes mellitus and chronic obstructive pulmonary disease. This is the first observation of this Hb variant in a German family thus far. The detailed evaluation of its structure using electrospray mass spectrometry revealed new minor glycohemoglobin components and showed that the attachment of glucose to the β NH2 terminus occurred at an almost identical rate in both wild-type and mutant β-chains. However, the introduction of a carboxyl group at β69 seems to increase the glycation of ε-amino groups of lysine residues. The glycemic state in the propositus was well reflected by the total glycohemoglobin concentrations but not by the Hb A1C values, which did not reflect hemoglobin glycation in this patient. This case demonstrates that Hb A1C cannot be used reliably in the management of diabetic patients carrying Hb variants such as Hb Rambam. Functional studies of the whole blood of the heterozygous carrier demonstrated extremely low oxygen affinity, which may have been caused by increased 2,3-diphosphoglycerate related to chronic obstructive pulmonary disease and hyperthyroidism. None of the clinical symptoms could be directly associated to Hb Rambam.

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