324. Evaluating the Barrier Effectiveness of TYVEK® Spunbonded Olefin Protective Clothing Fabrics and Other Commercial Spunbonded/Meltblown/Spunbonded Fabrics to Aerosolized Chrysotile Asbestos Fibers

1999 ◽  
Author(s):  
D. Warheit ◽  
M. Hartsky
Keyword(s):  
Protective Clothing ◽  
Chrysotile Asbestos ◽  
Asbestos Fibers

Asbestos fiber identification in liver from cholangiocarcinoma patients living in an asbestos polluted area: a preliminary study

2019 ◽  
Vol 105 (5) ◽  
pp. 404-410 ◽  
Author(s):  
Federica Grosso ◽  
Alessandro Croce ◽  
Roberta Libener ◽  
Narciso Mariani ◽  
Massimo Pastormerlo ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Asbestos Exposure ◽  
Optical Microscope ◽  
Variable Pressure ◽  
Chrysotile Asbestos ◽  
Neoplastic Tissue ◽  
Asbestos Fibers ◽  
Preliminary Study ◽  
Scanning Electron

Purpose: To assess whether asbestos fibers may be observed in liver tissue of patients with cholangiocarcinoma (CC) with environmental or working asbestos exposure. Methods: Detection of fibers was performed directly on histologic sections of liver from 7 patients with CC using optical microscope and variable pressure scanning electron microscopy equipped with energy-dispersive spectroscopy (VP-SEM/EDS). All patients were from Casale Monferrato, Italy, a highly asbestos-polluted town. Due to ethical constraints, observers were blinded to patients’ clinical features. Results: Fibers/bundles of fibers of chrysotile were detected in 5 out of 7 patients (71%). The boundary between healthy and neoplastic tissue or the fibrocollagen tissue produced by the neoplasia were identified as areas of fiber incorporation. Conclusions: This study is the first report about the detection of chrysotile asbestos fibers in the liver of patients with CC. Further studies on larger cohorts are needed to corroborate our preliminary findings.

Vitronectin adsorption to chrysotile asbestos increases fiber phagocytosis and toxicity for mesothelial cells

2000 ◽  
Vol 279 (5) ◽  
pp. L916-L923 ◽  
Author(s):  
J. Wu ◽  
W. Liu ◽  
K. Koenig ◽  
S. Idell ◽  
V. C. Broaddus
Keyword(s):  
Surface Area ◽  
Mesothelial Cells ◽  
Lower Amount ◽  
Target Cells ◽  
Chrysotile Asbestos ◽  
Adhesive Protein ◽  
Asbestos Fibers ◽  
Arginine Glycine Aspartic Acid ◽  
Biological Modification ◽  
Integrin Ligand

Biological modification of asbestos fibers can alter their interaction with target cells. We have shown that vitronectin (VN), a major adhesive protein in serum, adsorbs to crocidolite asbestos and increases fiber phagocytosis by mesothelial cells via integrins. Because chrysotile asbestos differs significantly from crocidolite in charge and shape, we asked whether VN would also adsorb to chrysotile asbestos and increase its toxicity for mesothelial cells. We found that VN, either from purified solutions or from serum, adsorbed to chrysotile but at a lower amount per surface area than to crocidolite. Nevertheless, VN coating increased the phagocytosis of chrysotile as well as of crocidolite asbestos. VN coating of both chrysotile and crocidolite, but not of glass beads, increased intracellular oxidation and apoptosis of mesothelial cells. The additional apoptosis could be blocked by integrin-ligand blockade with arginine-glycine-aspartic acid peptides, confirming a role for integrins in the fiber-induced toxicity. We conclude that VN increases the phagocytosis of chrysotile as well as of crocidolite asbestos and that phagocytosis is important in fiber-induced toxicity for mesothelial cells.

scholarly journals Persistence of Long, Thin Chrysotile Asbestos Fibers in the Lungs of Rats

1994 ◽  
Vol 102 ◽  
pp. 197 ◽  
Author(s):  
Patrick G. Coin ◽  
Victor L. Roggli ◽  
Arnold R. Brody
Keyword(s):  
Chrysotile Asbestos ◽  
Asbestos Fibers

Intrapulmonary deposition and retention modeling of chrysotile asbestos fibers in rats

1991 ◽  
Vol 22 (6) ◽  
pp. 757-763 ◽  
Author(s):  
C.P. Yu ◽  
B. Asgharian ◽  
K.E. Pinkerton
Keyword(s):  
Chrysotile Asbestos ◽  
Asbestos Fibers
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