scholarly journals Penetration of >5-. mu. chrysotile asbestos fibers through DuPont Tyvek 1422A and Kimberly-Clark CPF fabrics

1981 ◽  
Author(s):  
R Weeks, Jr ◽  
M McLeod
Keyword(s):  
Chrysotile Asbestos ◽  
Asbestos Fibers

Asbestos fiber identification in liver from cholangiocarcinoma patients living in an asbestos polluted area: a preliminary study

2019 ◽  
Vol 105 (5) ◽  
pp. 404-410 ◽  
Author(s):  
Federica Grosso ◽  
Alessandro Croce ◽  
Roberta Libener ◽  
Narciso Mariani ◽  
Massimo Pastormerlo ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Asbestos Exposure ◽  
Optical Microscope ◽  
Variable Pressure ◽  
Chrysotile Asbestos ◽  
Neoplastic Tissue ◽  
Asbestos Fibers ◽  
Preliminary Study ◽  
Scanning Electron

Purpose: To assess whether asbestos fibers may be observed in liver tissue of patients with cholangiocarcinoma (CC) with environmental or working asbestos exposure. Methods: Detection of fibers was performed directly on histologic sections of liver from 7 patients with CC using optical microscope and variable pressure scanning electron microscopy equipped with energy-dispersive spectroscopy (VP-SEM/EDS). All patients were from Casale Monferrato, Italy, a highly asbestos-polluted town. Due to ethical constraints, observers were blinded to patients’ clinical features. Results: Fibers/bundles of fibers of chrysotile were detected in 5 out of 7 patients (71%). The boundary between healthy and neoplastic tissue or the fibrocollagen tissue produced by the neoplasia were identified as areas of fiber incorporation. Conclusions: This study is the first report about the detection of chrysotile asbestos fibers in the liver of patients with CC. Further studies on larger cohorts are needed to corroborate our preliminary findings.

Vitronectin adsorption to chrysotile asbestos increases fiber phagocytosis and toxicity for mesothelial cells

2000 ◽  
Vol 279 (5) ◽  
pp. L916-L923 ◽  
Author(s):  
J. Wu ◽  
W. Liu ◽  
K. Koenig ◽  
S. Idell ◽  
V. C. Broaddus
Keyword(s):  
Surface Area ◽  
Mesothelial Cells ◽  
Lower Amount ◽  
Target Cells ◽  
Chrysotile Asbestos ◽  
Adhesive Protein ◽  
Asbestos Fibers ◽  
Arginine Glycine Aspartic Acid ◽  
Biological Modification ◽  
Integrin Ligand

Biological modification of asbestos fibers can alter their interaction with target cells. We have shown that vitronectin (VN), a major adhesive protein in serum, adsorbs to crocidolite asbestos and increases fiber phagocytosis by mesothelial cells via integrins. Because chrysotile asbestos differs significantly from crocidolite in charge and shape, we asked whether VN would also adsorb to chrysotile asbestos and increase its toxicity for mesothelial cells. We found that VN, either from purified solutions or from serum, adsorbed to chrysotile but at a lower amount per surface area than to crocidolite. Nevertheless, VN coating increased the phagocytosis of chrysotile as well as of crocidolite asbestos. VN coating of both chrysotile and crocidolite, but not of glass beads, increased intracellular oxidation and apoptosis of mesothelial cells. The additional apoptosis could be blocked by integrin-ligand blockade with arginine-glycine-aspartic acid peptides, confirming a role for integrins in the fiber-induced toxicity. We conclude that VN increases the phagocytosis of chrysotile as well as of crocidolite asbestos and that phagocytosis is important in fiber-induced toxicity for mesothelial cells.

scholarly journals Persistence of Long, Thin Chrysotile Asbestos Fibers in the Lungs of Rats

1994 ◽  
Vol 102 ◽  
pp. 197 ◽  
Author(s):  
Patrick G. Coin ◽  
Victor L. Roggli ◽  
Arnold R. Brody
Keyword(s):  
Chrysotile Asbestos ◽  
Asbestos Fibers

Intrapulmonary deposition and retention modeling of chrysotile asbestos fibers in rats

1991 ◽  
Vol 22 (6) ◽  
pp. 757-763 ◽  
Author(s):  
C.P. Yu ◽  
B. Asgharian ◽  
K.E. Pinkerton
Keyword(s):  
Chrysotile Asbestos ◽  
Asbestos Fibers

Alternative interpretation of electron diffraction patterns from chrysotile asbestos fibers

1995 ◽  
Vol 53 ◽  
pp. 164-165
Author(s):  
P. Ling ◽  
H. Ling ◽  
H. Kawayoshi ◽  
F. Tsai ◽  
R. Gronsky ◽  
...  
Keyword(s):  
Diffuse Scattering ◽  
High Resolution Electron Microscopy ◽  
Alternative Interpretation ◽  
Circular Cylinders ◽  
Chrysotile Asbestos ◽  
X Ray Diffraction ◽  
Asbestos Fibers ◽  
Single Side ◽  
Resolution Electron ◽  
Diffraction Patterns

Chrysotile asbestos fibers have been the object of intensive study for many years, and their structure and growth mechanisms have perplexed investigators ever since the original 1930 X-ray diffraction work of Warren and Bragg confused superlattice for fundamental reflections along two of the three unit cell directions. Even after the lattice parameters were accurately found, the origins of the characteristic and plentiful diffuse scattering seen in diffraction patterns challenged the most careful analyses. In 1956, Whittaker performed very detailed calculations of the scattering from fibers that were assumed to adopt the structure of concentric circular cylinders, yet could not obtain agreement with experimental results, especially the intensity distribution of subsidiary maxima(diffuse scattering) bordering Bragg reflections on a single side. It took the beautiful high-resolution electron microscopy of Yada to show that the fibers were actually spiral cylinders rather than circular cylinders, an observation that removed some of the minor discrepancies in Whittaker's model.

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