scholarly journals Angiotensin type 1 receptor blockade prevents endocardial dysfunction of rapidly paced atria in rats

2007 ◽  
Vol 8 (3) ◽  
pp. 127 ◽  
Author(s):  
Takeshi Yamashita ◽  
Akiko Sekiguchi ◽  
Takeshi Kato ◽  
Takayuki Tsuneda ◽  
Yu-ki Iwasaki ◽  
...  
Keyword(s):  
Receptor Blockade ◽  
Angiotensin Type

Angiotensin type 2 receptors mediate depressor phase of biphasic pressure response to angiotensin

1993 ◽  
Vol 264 (5) ◽  
pp. R917-R923 ◽  
Author(s):  
D. A. Scheuer ◽  
M. H. Perrone
Keyword(s):  
Pressor Response ◽  
Pressure Response ◽  
Receptor Blockade ◽  
At1 Receptors ◽  
Angiotensin Iii ◽  
Depressor Action ◽  
Angiotensin Type ◽  
At2 Receptors

Angiotensin (ANG) can produce a biphasic arterial pressure response, i.e., an increase followed by a decrease. Because ANG type 1 (AT1) receptors mediate the pressor response to ANG, we hypothesized that the opposing depressor action is mediated by the ANG type 2 (AT2) receptors. In thiobutabarbital (Inactin)-anesthetized rats bolus injections of angiotensin III (ANG III; 100, 300, and 1,000 ng/kg iv) produced peak increases in MAP at 20 s of 13.4 +/- 1.4, 20.1 +/- 2, and 27.5 +/- 2.8 mmHg and maximum decreases in pressure at 120 s of -6.3 +/- 1.5, -6.8 +/- 2.2, and -11.4 +/- 4.9 mmHg. During blockade of the AT1 receptors with DuP 753 (losartan, 10 mg/kg) the increases in MAP were eliminated (P < 0.01), whereas the depressor responses (-24.7 +/- 8, -32.8 +/- 9.3, and -42.0 +/- 10.0 mmHg) were significantly (P < 0.05) larger. In separate groups of rats, combined blockade of both AT1 and AT2 receptors eliminated all changes in MAP in response to ANG III, whereas blockade of AT2 receptors alone enhanced the pressor response to ANG III. During AT1 receptor blockade angiotensin II also caused consistent decreases in pressure, which were inhibited during combined blockade of AT1 and AT2 receptors. Therefore, we have demonstrated that the AT2 receptors mediate a depressor response to ANG.

scholarly journals The effect of angiotensin type 1 receptor blockade on adhesion molecules in patients with IgA nephropathy

2008 ◽  
Vol 1 (5) ◽  
pp. 377-377
Author(s):  
D. Xydakis ◽  
A. Papadogiannakis ◽  
M. Sfakianaki ◽  
K. Kostakis ◽  
A. Sfyridakh
Keyword(s):  
Iga Nephropathy ◽  
Adhesion Molecules ◽  
Receptor Blockade ◽  
Angiotensin Type

scholarly journals Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat

2012 ◽  
Vol 176 (1-3) ◽  
pp. 36-44 ◽  
Author(s):  
Adam Whaley-Connell ◽  
Javad Habibi ◽  
Ravi Nistala ◽  
Melvin R. Hayden ◽  
Lakshmi Pulakat ◽  
...  
Keyword(s):  
Kidney Injury ◽  
Receptor Blockade ◽  
Renin Inhibition ◽  
Angiotensin Type

scholarly journals Angiotensin Type 1 Receptor Blockade Prevents Cardiac Remodeling in Mice with Pregnancy-Associated Hypertension

2008 ◽  
Vol 31 (12) ◽  
pp. 2165-2175 ◽  
Author(s):  
Akira SAKAIRI ◽  
Junji ISHIDA ◽  
Kaori HONJO ◽  
Saki INABA ◽  
Shoko NAKAMURA ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Receptor Blockade ◽  
Angiotensin Type
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