scholarly journals Cardioprotective Effects of Vasopeptidase Inhibition vs. Angiotensin Type 1-Receptor Blockade in Spontaneously Hypertensive Rats on a High Salt Diet

2004 ◽  
Vol 27 (8) ◽  
pp. 609-618 ◽  
Author(s):  
Tina GRÖHOLM ◽  
Piet FINCKENBERG ◽  
Eeva PALOJOKI ◽  
Antti SARASTE ◽  
Tom BÄCKLUND ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Receptor Blockade ◽  
Hypertensive Rats ◽  
High Salt Diet ◽  
Salt Diet ◽  
Spontaneously Hypertensive ◽  
Vasopeptidase Inhibition ◽  
Cardioprotective Effects ◽  
Angiotensin Type

scholarly journals TANNIC ACID AN INHIBITOR FOR ANGIOTENSIN TYPE 1 RECEPTOR AND HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Upendra Gumaste ◽  
Russell Snyder ◽  
Sivaramakrishna Koganti ◽  
Vardan Karamyan ◽  
Thomas Thekkumkara
Keyword(s):  
Tannic Acid ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Angiotensin Type

scholarly journals Effects of Valsartan on Mechanical Properties of the Carotid Artery in Spontaneously Hypertensive Rats Under High-Salt Diet

Hypertension ◽  
2001 ◽  
Vol 38 (3) ◽  
pp. 439-443 ◽  
Author(s):  
Carlos Labat ◽  
Patrick Lacolley ◽  
Malika Lajemi ◽  
Marc de Gasparo ◽  
Michel E. Safar ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Carotid Artery ◽  
Spontaneously Hypertensive Rats ◽  
High Salt ◽  
Hypertensive Rats ◽  
High Salt Diet ◽  
Salt Diet ◽  
Spontaneously Hypertensive

Genetic linkage of albuminuria and renal injury in Dahl salt-sensitive rats on a high-salt diet: comparison with spontaneously hypertensive rats

2004 ◽  
Vol 18 (2) ◽  
pp. 218-225 ◽  
Author(s):  
Anja-Kristin Siegel ◽  
Peter Kossmehl ◽  
Michael Planert ◽  
Angela Schulz ◽  
Markus Wehland ◽  
...  
Keyword(s):  
Renal Injury ◽  
Spontaneously Hypertensive Rats ◽  
High Salt ◽  
Hypertensive Rats ◽  
Tubulointerstitial Injury ◽  
High Salt Diet ◽  
Salt Diet ◽  
Spontaneously Hypertensive ◽  
Damage Indices ◽  
Salt Sensitive Hypertension

Our aim was to study the effects of high-salt diet on the genetics of albuminuria and renal injury in the Dahl salt-sensitive (SS) rat. We compared SS with salt-resistant spontaneously hypertensive rats (SHR) and with genetically related salt-sensitive stroke-prone SHR (SHRSP). Moreover, we performed genome-wide linkage analysis to identify quantitative trait loci (QTL) contributing to salt-induced renal injury in an F2 population derived from SS and SHR ( n = 230). In response to high-salt diet SS and SHRSP developed a striking increase in systolic blood pressure, urinary albumin excretion (UAE), and renal damage indices compared with SHR. Both SHRSP and SS developed severe glomerulosclerosis, whereas microangiopathy, tubulointerstitial fibrosis, and inflammation were more pronounced in SHRSP. We detected two QTL with significant linkage to UAE on rat chromosomes (RNO) 6 and 19. Comparison with the recently identified salt-independent UAE QTL in young animals revealed that the UAE QTL on RNO6 is unique to high-salt conditions, whereas RNO19 plays a significant role during both low- and high-salt conditions. Some F2 animals demonstrated severe microangiopathy and tubulointerstitial injury, which exceeded the degree observed in the parental SS strain. Three loci demonstrated suggestive linkage to these phenotypes on RNO3, RNO5, and RNO20, whereas no linkage to glomerular damage was found. Further analyses at these loci indicated that the severity of renal injury was attributable to the SHR allele. Our data suggest that the SHR genetic background confers greater susceptibility for the development of microangiopathy and tubulointerstitial injury in salt-sensitive hypertension than the SS background.

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