scholarly journals The Influence of Statins on Bone Tissue in Ovariectomized Rats

2018 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Bone Density ◽  
Mass Density ◽  
Dual Energy ◽  
Bone Architecture ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Bone Mass Density ◽  
X Ray ◽  
Skeletal Disease ◽  
Coa Reductase

Objectives: Osteoporosis is a silent, progressive, systemic skeletal disease characterized by impaired bone architecture with decreased bone mass density, affecting mainly women. Statins, inhibitors of HMG-CoA-reductase, seem to interfere with bone formation exerting anabolic and anti-resorptive effect. The aim of the present study is to investigate the effect of simvastatin on size parameters and bone density of mandible and femur, in an ovariectomized rat model of osteoporosis. Methods: 50 Wistar female rats were randomized in five groups (n=10). Groups 1, 2,3 were ovariectomized, 4 and 5 serve as controls. Groups 2, 3 and 5 were treated with simvastatin (0.5mg/kg/daily per os). Size parameters of the isolated femur, mandible and uterus, BMD via dual energy X-Ray absorptiometry (DEXA) and serum interleukin-13 (IL-13) were estimated. Results: DEXA results showed significant decrease of BMD in ovariectomized group / controls while statins treatment decreased the severity of BMD lose. The serum IL-13, as osteogenesis index, seems to be positively influenced by statins treatment. Conclusions: Statins treatment seems to restore the decreased femur and mandible parameters and uterus weight in experimental menopause following ovariectomy.

scholarly journals Autoimmunological serum parameters and bone mass density in premature ovarian insufficiency: a retrospective cohort study

2020 ◽  
Author(s):  
Klara Beitl ◽  
Klara Rosta ◽  
Nina Poetsch ◽  
Manuel Seifried ◽  
Daniel Mayrhofer ◽  
...  
Keyword(s):  
Bone Mass ◽  
Retrospective Cohort ◽  
Mass Density ◽  
Dual Energy ◽  
Premature Ovarian Insufficiency ◽  
Bone Mass Density ◽  
Ovarian Insufficiency ◽  
X Ray ◽  
T Score ◽  
Normal Women

Abstract Purpose It is still not clear whether to screen women with primary premature ovarian insufficiency for autoimmunity. Moreover, a possible association of autoimmunity with decreased bone mass density in premature ovarian insufficiency patients has not been evaluated. Thus, the objectives of this study were to review our experience with the use of an autoimmune screening panel in premature ovarian insufficiency women and to focus on bone mass density. Methods In a retrospective cohort study, 76 chromosomally normal women with primary premature ovarian insufficiency were included. The main outcome parameters were the results of an autoimmune screening panel and of dual-energy X-ray absorptiometry. Results Median age was 33 years. Sixty percent of premature ovarian insufficiency patients revealed abnormal dual-energy X-ray absorptiometry results (minimal T-score < −1.0). Any signs of autoimmunity were found in 21 women (36.2%). The most frequent abnormal results were increased thyroperoxidase antibodies (24.1%) and thyroglobulin antibodies (20.7%). A longer duration of amenorrhea (β = −0.015; p = 0.007), any abnormality during autoimmune screening (β = −0.940; p = 0.010), and a lower body mass index (β = −0.057; p = 0.036) were associated with a lower minimal T-score. Conclusion In chromosomally normal women with primary premature ovarian insufficiency, the prevalence of autoimmunity and decreased bone mass density seem high. Our data highlight the association between autoimmune abnormalities and decreased dual-energy X-ray absorptiometry results.

scholarly journals Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss

2015 ◽  
Vol 227 (3) ◽  
pp. 129-141 ◽  
Author(s):  
Russell T Turner ◽  
Michael Dube ◽  
Adam J Branscum ◽  
Carmen P Wong ◽  
Dawn A Olson ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Body Weight ◽  
Bone Loss ◽  
Bone Mass ◽  
Bone Turnover ◽  
Cancellous Bone ◽  
Mass Density ◽  
Female Rats ◽  
Bone Mass Density ◽  
Age Related

Excessive weight gain in adults is associated with a variety of negative health outcomes. Unfortunately, dieting, exercise, and pharmacological interventions have had limited long-term success in weight control and can result in detrimental side effects, including accelerating age-related cancellous bone loss. We investigated the efficacy of using hypothalamic leptin gene therapy as an alternative method for reducing weight in skeletally-mature (9 months old) female rats and determined the impact of leptin-induced weight loss on bone mass, density, and microarchitecture, and serum biomarkers of bone turnover (CTx and osteocalcin). Rats were implanted with cannulae in the 3rd ventricle of the hypothalamus and injected with either recombinant adeno-associated virus encoding the gene for rat leptin (rAAV-Leptin,n=7) or a control vector encoding green fluorescent protein (rAAV-GFP,n=10) and sacrificed 18 weeks later. A baseline control group (n=7) was sacrificed at vector administration. rAAV-Leptin-treated rats lost weight (−4±2%) while rAAV-GFP-treated rats gained weight (14±2%) during the study. At study termination, rAAV-Leptin-treated rats weighed 17% less than rAAV-GFP-treated rats and had lower abdominal white adipose tissue weight (−80%), serum leptin (−77%), and serum IGF1 (−34%). Cancellous bone volume fraction in distal femur metaphysis and epiphysis, and in lumbar vertebra tended to be lower (P<0.1) in rAAV-GFP-treated rats (13.5 months old) compared to baseline control rats (9 months old). Significant differences in cancellous bone or biomarkers of bone turnover were not detected between rAAV-Leptin and rAAV-GFP rats. In summary, rAAV-Leptin-treated rats maintained a lower body weight compared to baseline and rAAV-GFP-treated rats with minimal effects on bone mass, density, microarchitecture, or biochemical markers of bone turnover.

scholarly journals General Influence of Biphasic Calcium Phosphate on Osteoporotic Bone Density

2019 ◽  
Vol 73 (2) ◽  
pp. 185-188
Author(s):  
Vladislavs Ananjevs ◽  
Aleksandra Ananjeva ◽  
Jānis Vētra ◽  
Andrejs Skaģers ◽  
Ilze Salma ◽  
...  
Keyword(s):  
Bone Density ◽  
Mass Density ◽  
Cone Beam ◽  
Bone Mass Density ◽  
Osteoporotic Bone ◽  
Left Femur ◽  
Experimental Osteoporosis ◽  
The Right ◽  
General Influence

Abstract Bone density of the femur body of rabbit was determined in vivo. Experimental osteoporosis was induced by ovariectomy and subsequent injections of methylprednisolone. In the greater trochanter region of right femur, defects were created and filled with granules of hydroxyapatite and tricalcium phosphate (HAP/TCP 70/30) or HAP/TCP 70/30 together with 5% strontium. After three months, the animals were euthanized. The bone mass density of the right and left body of femur was measured by cone beam computed tomography (CT) scan. The results of the study showed that the right femur of the rabbit, where biomaterials had been implanted, and the left femur, where no biomaterial implantation occurred, became denser after filling the defect with HAP/TCP 70/30 ceramic granules or 5% Sr modified HAP/TCP ceramic granules. There was no difference between operated and non-operated legs and HAP/TCP and HAP/TCP with 5% strontium groups.

Dual Energy X-Ray Absorptiometry-Based Assessment of Male Patients Using Standardized Bone Density Values and a National Reference Database

2007 ◽  
Vol 10 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Stefan Goemaere ◽  
Dirk Vanderschueren ◽  
Jean-Marc Kaufman ◽  
Jean-Yves Reginster ◽  
Yves Boutsen ◽  
...  
Keyword(s):  
Bone Density ◽  
Dual Energy ◽  
Reference Database ◽  
X Ray ◽  
National Reference ◽  
Density Values ◽  
Male Patients
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