scholarly journals Povidone iodine hookah therapy for the treatment of COVID-19 and other respiratory virus: A hypothesis we must test

2021 ◽  
Vol 5 (1) ◽  
pp. e000258
Author(s):  
Raj K Gandhi
Keyword(s):  
Dosage Form ◽  
Therapeutic Agent ◽  
Respiratory Virus ◽  
Povidone Iodine ◽  
Clinical Use ◽  
Long Time ◽  
Antiseptic Agent

Povidone – Iodine has been known to have strong bactericidal and virucidal properties for a long time. It has been in clinical use as an antiseptic agent for over fifty years. Now a new indication for this old drug is recommended as Hookah therapy. It is hypothesized that in this form it will be an effective therapeutic agent to kill the coronavirus (SARS-COV2) or significantly inhibit its multiplication to achieve a cure. Details of treatment and dosage form are presented.

Versatile Use of Nanosponge in the Pharmaceutical Arena: A Mini-Review

2020 ◽  
Vol 14 (4) ◽  
pp. 351-359
Author(s):  
Shubham Shrestha ◽  
Sankha Bhattacharya
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Porous Structure ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Carrier System ◽  
Current Review ◽  
Long Time ◽  
Preparation Techniques

Drug delivery for a long time has been a major problem in the pharmaceutical field. The development of a new Nano-carrier system called nanosponge has shown the potential to solve the problem. Nanosponge has a porous structure and can entrap the drug in it. It can carry both hydrophilic and hydrophobic drugs. They also provide controlled release of the drugs and can also protect various substances from degradation. Nanosponge can increase the solubility of drugs and can also be formulated into an oral, topical and parenteral dosage form. The current review explores different preparation techniques, characterization parameters, as well as various applications of nanosponge. Various patents related to nanosponge drug delivery system have been discussed in this study.

scholarly journals Gut Microbiota and Response to Immunotherapeutic Drugs in Oncology: More Questions Than Answers

2020 ◽  
Vol 14 ◽  
pp. 117955492093386
Author(s):  
Dhiraj Abhyankar ◽  
Kelly T McKee ◽  
Pavle Vukojevic
Keyword(s):  
Gut Microbiota ◽  
Gut Microbiome ◽  
Clinical Evidence ◽  
Response Rate ◽  
Clinical Use ◽  
Patients With Cancer ◽  
Long Time ◽  
Gut Microorganisms

Immuno-oncology drugs (IODs) have revolutionized the treatment of some cancers. Although IODs are enabling some patients with cancer to become long-time survivors, only 30% to 40% respond to these drugs. There is experimental and clinical evidence that the gut microbiome may play a role in IOD response, leading to speculation that manipulation of the gut microenvironment might improve the response rate to IODs. We review the evidence relating to how gut microorganisms may affect response to IODs and discuss the implications of targeting the microbiome to improve IOD response, including the challenges to refine and translate the findings to practical clinical use.

scholarly journals The preparation of anti-typhoid serum in the horse for therapeutic use in man

1938 ◽  
Vol 38 (6) ◽  
pp. 673-682 ◽  
Author(s):  
A. Felix ◽  
G. F. Petrie
Keyword(s):  
Typhoid Fever ◽  
Therapeutic Agent ◽  
Salmonella Typhi ◽  
Therapeutic Use ◽  
Antigenic Structure ◽  
Clinical Use ◽  
Permissible Limits ◽  
Technical Details ◽  
High Level

The object of this paper is to describe the immunizing procedures that have proved to be the most suitable up to the present time for preparing a potent serum from the horse for the treatment of typhoid fever. The principles on which the methods are based have their origin in the studies of Felix and his collaborators on the antigenic structure of Salmonella typhi. The technical details that follow will, we hope, assist those who are interested in the preparation of the serum as a therapeutic agent to obtain products which maintain a consistently high level of potency. This objective is not readily attained, but is of paramount importance, because the clinical use of products that fall below the permissible limits of potency would tend to bring discredit upon the serum as a specific remedy owing to insufficient dosage. The adoption of standards of potency that are prescribed by an official authority is an obvious desideratum and would guard against this risk, but in the meantime we shall be pleased to help by providing the requisite cultures and serological reagents.

scholarly journals Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and SARS-CoV-2 variants

2021 ◽  
Author(s):  
Nicole L Welch ◽  
Meilin Zhu ◽  
Catherine Hau ◽  
Juliane Weller ◽  
Marzieh Ezzaty Mirhashemi ◽  
...  
Keyword(s):  
High Throughput ◽  
Quantitative Measurement ◽  
Respiratory Virus ◽  
Cost Effective ◽  
Respiratory Viruses ◽  
Variant Classification ◽  
Clinical Use ◽  
Clinical Testing ◽  
Variant Detection ◽  
Grade Performance

The COVID-19 pandemic has demonstrated a clear need for high-throughput, multiplexed, and sensitive assays for detecting SARS-CoV-2 and other respiratory viruses as well as their emerging variants. Here, we present microfluidic CARMEN (mCARMEN), a cost-effective virus and variant detection platform that combines CRISPR-based diagnostics and microfluidics with a streamlined workflow for clinical use. We developed the mCARMEN respiratory virus panel (RVP) and demonstrated its diagnostic-grade performance on 533 patient specimens in an academic setting and then 166 specimens in a clinical setting. We further developed a panel to distinguish 6 SARS-CoV-2 variant lineages, including Delta and Omicron, and evaluated it on 106 patient specimens, with near-perfect concordance to sequencing-based variant classification. Lastly, we implemented a combined Cas13 and Cas12 approach that enables quantitative measurement of viral copies in samples. mCARMEN enables high-throughput surveillance of multiple viruses and variants simultaneously.

scholarly journals A Critical Review and Significance of Ayurvedic preparation Kwatha - Herbal decoction

2020 ◽  
Vol 11 (2) ◽  
pp. 155-164
Author(s):  
Narendra Someshwar Bhatt ◽  
Manasi Deshpande
Keyword(s):  
Critical Review ◽  
Dosage Form ◽  
Academic Research ◽  
Dosage Forms ◽  
Clinical Use ◽  
Basic Principles ◽  
Classical Information ◽  
Herbal Decoction ◽  
Basic Concepts ◽  
Preparatory Method

The standardization of Ayurvedic classical dosage forms has been an area of academic, research, industrial and regulatory interests.  It is crucial to understand the basic principles and rationality of these dosage forms for their therapeutic relevance while adapting to newer technologies for its right pharmaceutical and clinical use. Kwatha Kalpana -frequently referred to as decoctions - aqueous extraction of a group of herbs, is one of the most commonly used classical dosage forms where the therapeutic attributes are extracted from the group of botanicals into water, with the use of heat. Though clinically effective, it is seldom used due to the cumbersome preparatory method, short shelf life and poor palatability. This elaborate review covers historical and basic concepts of the dosage form, its salient features, nuances of classical preparations, traditional and newly developed methods of preparations. This paper covers intricate classical information and specifics about Kwatha, the herbal decoction. 

scholarly journals Comparative Study of Bacterial Growth Inhibitory Effect of Three Types of Mouthwashes Marketed in Japan Containing Povidone Iodine, Benzethonium Chloride, and Chlorhexidine Gluconate by Bacterial Culture

2021 ◽  
Vol 7 (6) ◽  
Author(s):  
Funahara M ◽  
Tsujisawa T ◽  
Honda H ◽  
Yoshiga D ◽  
Yoshioka I ◽  
...  
Keyword(s):  
Povidone Iodine ◽  
Bacterial Culture ◽  
Inhibitory Effect ◽  
Chlorhexidine Gluconate ◽  
Pathogenic Microorganisms ◽  
Growth Inhibitory Effect ◽  
Benzethonium Chloride ◽  
Growth Inhibitory ◽  
Antiseptic Agent ◽  
Pathogen Populations

Purpose: Pathogenic microorganisms in saliva are thought to be a major cause of surgical site infection in patients who have undergone surgery for head and neck or upper digestive tract cancers, and a common cause of postoperative pneumonia and aspiration pneumonia in elderly people. Gargling with a mouthwash containing an antiseptic agent is recommended to control salivary pathogen populations, but it is not clear which antiseptic agents are most effective. The purpose of this study is to examine the potencies of three antiseptic mouthwashes marketed in Japan against salivary bacteria.

scholarly journals Aiweixin, a Traditional Uyghur Medicinal Formula, Extends the Lifespan of Caenorhabditis elegans

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Binggen Zhu ◽  
Kayama Jo ◽  
Ping Yang ◽  
Jurat Tohti ◽  
Jian Fei ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Signaling Pathway ◽  
Life Extension ◽  
Clinical Use ◽  
Wild Type ◽  
Traditional Uyghur Medicine ◽  
Medicine Prescription ◽  
Long Time ◽  
Extension Effect

Aiweixin (AWX) is a traditional Uyghur medicine prescription, which has been used to treat senile diseases for a long time. We investigate whether the AWX extends the lifespan of Caenorhabditis elegans. The AWX decoction was the conventional product for clinical use. The wild-type Caenorhabditis elegans (N2) and mutational worms, daf-16(mu86), glp-1(e2141), daf-2(e1370), and eat-2(ad465), were applied for the lifespan analysis. We found that the lifespan of the N2 adults' worm received 0.005 and 0.01 volume of AWX/total volume was extended significantly, compared to the control without treatment of AWX. The AWX at 0.01 volume of AWX/total volume significantly prolonged the life of both mutational worms, daf-16 (mu86) and eat-2(ad465), but did not increase the lifespan of the mutational worms, daf-2(e1370) and glp-1(e2141). These results indicated that the AWX significantly extended the lifespan of wild-type nematodes, and the life extension effect of AWX was related to the germline longevity pathway and IIS signaling pathway but independent of DAF-16/FOXO.

Lack of Influence of Povidone-Iodine on Tests of Thyroid Function

1978 ◽  
Vol 6 (5) ◽  
pp. 406-408 ◽  
Author(s):  
D P Lividas ◽  
G D Piperingos ◽  
J Sfontouris ◽  
D A Koutras
Keyword(s):  
Thyroid Function ◽  
Povidone Iodine ◽  
Test Methods ◽  
Thyroid Function Tests ◽  
In Vitro Test ◽  
External Application ◽  
Vitro Test ◽  
Antiseptic Agent

The external application of povidone-iodine, an antiseptic agent, was tested for its influence on thyroid function. Previous workers have described some in vitro changes in thyroid function tests following its use. In the present study topical application of povidone-iodine did not affect thyroid function as measured some days later using both in vivo and radio-active iodine in vitro test methods, despite the fact that the latter are notorious for being influenced by exogenous iodine.

scholarly journals Slaying the Dragon

2015 ◽  
Vol 137 (04) ◽  
pp. 36-41
Author(s):  
Mauro Ferrari
Keyword(s):  
Mouse Models ◽  
Therapeutic Agent ◽  
Metastatic Cancer ◽  
Biomolecular Recognition ◽  
Clinical Use ◽  
Breast Cancers

This article explains how nanomechanics can be used to treat metastatic cancer. Metastatic cancers are the cancers that spread from the organ in which they originated to other organs. Indeed, the rate at which metastatic cancers, especially those that grow in the lungs, liver, and brain, are cured remains abysmally low and they are responsible for the vast majority of cancer deaths. Nanodrugs in current clinical use have extended the lives of many metastatic patients on the order of weeks to months. The nanodrugs use nanoparticle materials such as liposomes and albumin to be injected into the bloodstream. These nanoparticles can also be added with a decoration of biomolecular recognition agents on the surfaces, such as antibodies that recognize cancer specifically. A new, multifunctional therapeutic agent (MSV-pX) has also been demonstrated by researchers which completely cured about 50 percent of animals with breast cancers, metastatic to the lungs, in several different mouse models.

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