scholarly journals Pengaruh Pemberian Madu terhadap Perbaikan Kerusakan Mukosa Gaster dan Penyembuhan Luka pada Penderita Ulkus Peptikum

2021 ◽  
Vol 3 (1) ◽  
pp. 61-67
Author(s):  
Clarisa Rahmah
Keyword(s):  
Wound Healing ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Gastric Mucosa ◽  
Healing Process ◽  
Gastric Ulcers ◽  
Wound Healing Process ◽  
Peptic Ulcers ◽  
Literature Study ◽  
Anti Inflammatory

Background: Peptic ulcer is one of the diseases that many people experience in digestive tract disorders. Peptic ulcers occur due to excessive secretion of gastric acid (HCl) and pepsin by the gastric mucosa. Objectives: This discussion aims to determine the gastroprotector effect of honey on peptic ulcer healing. Methods: The method used is literature study from national and international journals by summarizing the discussion presented in the article. Discussion: The incidence of gastric ulcers commonly occurs due to because of Helicobacter pylori infection with increased mortality in older people with the use of Anti-Inflammatory Steroids (NSAIDs). Treatment and prevention of disease using traditional medicine that is widely reused, one of which is honey. Honey contains more than 200 compounds that are useful in the wound healing process such as anti-inflammatory, antibacterial, antioxidant, tissue stimulation, retaining moisture, and healing wound healing activities. Conclusion: Honey has a gastroprotective effect on the irritated stomach until the ulcer acts as an antibiotic, balancing gastric pH, and as an inducer of epithelialization of the gastric mucosa. Keywords: gastric, honey, mucosal repair, peptic ulcer, wound healing   Latar Belakang: Ulkus peptikum merupakan salah satu penyakit yang banyak dialami masyarakat dalam gangguan saluran pencernaan. Ulkus peptikum terjadi karena sekresi asam lambung (HCl) dan pepsin berlebih oleh mukosa lambung. Tujuan: Pembahasan ini bertujuan untuk mengetahui efek gastroprotektor pada madu terhadap penyembuhan ulkus peptikum. Metode: Metode yang digunakan studi literatur dari jurnal nasional dan internasional dengan merangkum pembahasan yang disajikan dalam artikel. Pembahasan: Insidensi tukak lambung banyak terjadi karena adanya infeksi Helicobacter pylori yang angka mortalitasnya meningkat pada orang tua dengan penggunaan Obat Anti Inflamasi Steroid (OAINS). Pengobatan dan pencegahan penyakit dengan obat tradisional/ herbal banyak digunakan kembali, salah satunya madu. Madu mengandung lebih dari 200 senyawa yang bermanfaat dalam proses penyembuhan luka seperti aktivitas antiinflamasi, antibakterial, antioksidan, stimulasi pengangkatan jaringan, mempertahankan kelembapan, dan mempercepat penyembuhan luka. Kesimpulan: Madu memiliki efek gastroprotektor pada mukosa gaster yang mengalami iritasi hingga ulkus berperan sebagai antibiotik, penyeimbang pH gaster, dan penginduksi epitelisasi mukosa gaster. Kata Kunci: gaster, madu, penyembuhan luka, perbaikan mukosa, ulkus peptikum

scholarly journals Anti-inflammatory activity of Schrebera Swietenioides Roxb. in cream formulation on CD68 expression in mice skin wound

2019 ◽  
Vol 9 (5) ◽  
pp. 39-42
Author(s):  
Piush Sharma ◽  
Charanjeet Singh
Keyword(s):  
Wound Healing ◽  
Surgical Procedures ◽  
Healing Process ◽  
Skin Incision ◽  
Skin Wound ◽  
Inflammatory Activity ◽  
Wound Healing Process ◽  
Male Mice ◽  
Entire Surface ◽  
Anti Inflammatory

Aim: The purpose of this study was to determine the potential of Schrebera Swietenioides alcohol leaf extract in cream composition in the expression of immunoglobulin CD68 (macrophage) during the wound healing process in the inflammatory stage of mice skin. Materials and Methods: Amount of 12 two-months-old male mice were used between 30 and 40 g. To surgical procedures, wound skin incision was performed 2.0 cm in length until subcutaneous on the paravertebral of each animal. The treatment was carried under locally anesthetized with procaine cream. The mice were allotted into four groups of each, entire surface of each group wound covered by base cream control, sulfadiazine 0.1% cream, alcoholic leaves extract of Schrebera Swietenioides cream 10% and, 15%, respectively. All experiments were performed twice a day for 3 days. The wound healing was assayed in stained histological sections in immunohistochemical of the wounds. CD68 expression was investigated under a microscope. Amount of 12-month-old male mice between 30 and 40 g was used. For surgical procedures, a 2.0 cm skin lesion was also performed under the skin on the vertebrae surrounding each animal. Treatment was performed under local anesthetic with procaine cream. Rats were assigned to four groups each, the entire surface of each group of lesions covered by control cream, 0.1% sulfadiazine cream, alcohol leaf from Schrebera Swietenioides cream respectively at 10% and at 15%. All tests were performed twice a day for 3 days. The lesions were analyzed in sections of tissue with staining of wound immunochemistry. The expression of CD68 was studied under a microscope. Results: The results showed that the cream from the 10% and 15% alcoholic leaves extract of Schrebera Swietenioides revealed moderate immune reaction to CD68 on wound healing. Conclusion: We concluded that the alcoholic leaves extract cream of Schrebera Swietenioides possesses anti-inflammatory activity in wound healing process of mice skin.

scholarly journals Isolation and Characterization of Wound Healing Compounds from Chloroform Extract of Binahong Leaves (Anredera cordifolia (Ten.) Steenis)

2021 ◽  
Vol 8 (1) ◽  
pp. 40
Author(s):  
Siti Rohani
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Chloroform Extract ◽  
Pharmaceutical Products ◽  
Wound Healing Process ◽  
Literature Study ◽  
Isolation And Characterization ◽  
Pure Compounds ◽  
Healing Agent ◽  
The One

The leaves of Binahong (Anredera cordifolia (Ten) Steenis) have been widely studied to have benefits and uses in various medical purposes, one of which is in the wound healing process. The existence of several active compounds contained in the leaves of the Binahong tree plant have an important role in wound healing, such as flavonoids, terpenoids, alkaloids, saponins, ascorbic acid and citrate compounds, these compounds are the targeted for further process of this natural product. The eminence of the extraction method that is used repeatedly and consistently to obtain pure compounds from Binahong leaves to be isolated is the one of topics discussed in this literature study. The perspective of implementation from liquid-solid extraction followed by liquid-liquid extraction using chloroform as a solvent is discussed comprehensively in this article. The identification of the isolation of compounds are able to conducted by implemented a thin layer chromatography (TLC) techniques, and for the further structural determination by UV, MS, FTIR, NMR spectroscopy and separation techniques using GC-MS. Respectively, the components are successfully to be identified and reported in previous research, for the following criteria that have been completed, some isolated active compound are purposed as the candidate for the wound healing agent. For the further application it is reasonable to implied these matters for some pharmaceutical products.

scholarly journals High Efficiency In Vitro Wound Healing of Dictyophora indusiata Extracts via Anti-Inflammatory and Collagen Stimulating (MMP-2 Inhibition) Mechanisms

2021 ◽  
Vol 7 (12) ◽  
pp. 1100
Author(s):  
Yasir Nazir ◽  
Pichchapa Linsaenkart ◽  
Chiranan Khantham ◽  
Tanakarn Chaitep ◽  
Pensak Jantrawut ◽  
...  
Keyword(s):  
Wound Healing ◽  
Interleukin 1 ◽  
Healing Process ◽  
Matrix Metalloproteinase 2 ◽  
Nucleotide Sequencing ◽  
Wound Healing Process ◽  
Healing Effect ◽  
Wound Healing Effect ◽  
Anti Inflammatory ◽  
Collagen Stimulation

Dictyophora indusiata or Phallus indusiatus is widely used as not only traditional medicine, functional foods, but also, skin care agents. Biological activities of the fruiting body from D. indusiata were widely reported, while the studies on the application of immature bamboo mushroom extracts were limited especially in the wound healing effect. Wound healing process composed of 4 stages including hemostasis, inflammation, proliferation, and remodelling. This study divided the egg stage of bamboo mushroom into 3 parts: peel and green mixture (PGW), core (CW), and whole mushroom (WW). Then, aqueous extracts were investigated for their nucleotide sequencing, biological compound contents, and wound healing effect. The anti-inflammatory determination via the levels of cytokine releasing from macrophages, and the collagen stimulation activity on fibroblasts by matrix metalloproteinase-2 (MMP-2) inhibitory activity were determined to serve for the wound healing process promotion in the stage 2–4 (wound inflammation, proliferation, and remodelling of the skin). All D. indusiata extracts showed good antioxidant potential, significantly anti-inflammatory activity in the decreasing of the nitric oxide (NO), interleukin-1 (IL-1), interleukin-1 (IL-6), and tumour necrosis factor-α (TNF-α) secretion from macrophage cells (p < 0.05), and the effective collagen stimulation via MMP-2 inhibition. In particular, CW extract containing high content of catechin (68.761 ± 0.010 mg/g extract) which could significantly suppress NO secretion (0.06 ± 0.02 µmol/L) better than the standard anti-inflammatory drug diclofenac (0.12 ± 0.02 µmol/L) and their MMP-2 inhibition (41.33 ± 9.44%) was comparable to L-ascorbic acid (50.65 ± 2.53%). These findings support that CW of D. indusiata could be an essential natural active ingredient for skin wound healing pharmaceutical products.

scholarly journals The Wound Healing Property of N-Methyl-(2S,4R)-trans-4-Hydroxy-L-Proline from Sideroxylon obtusifolium is Related to its Anti-Inflammatory and Antioxidant Actions

2019 ◽  
Vol 24 ◽  
pp. 2515690X1986516 ◽  
Author(s):  
Pedro Everson Alexandre de Aquino ◽  
Tamiris de Fátima Goebel de Souza ◽  
Flávia Almeida Santos ◽  
Ana Flávia Seraine Custódio Viana ◽  
Bianca Oliveira Louchard ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Wound Healing Process ◽  
Collagen Deposition ◽  
Control Groups ◽  
Wound Induction ◽  
Extracellular Matrix Components ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
And Control

Wound healing involves the interaction of blood cells, proteins, proteases, growth factors, and extracellular matrix components. Inflammation is one of the first events occurring during this process. Previously, we showed that the N-Methyl-(2S,4R)-trans-4-Hydroxy-L-Proline (NMP) from Sideroxylon obtusifolium leaves (a Brazilian medicinal species) presents an anti-inflammatory action. Considering inflammation as an important event in the wound healing process, the objectives were to investigate the topical effects of the NMP gel on a mice wound-induced model. Male Swiss mice were divided into 4 groups: Sham (surgical procedure only), Control (gel-base treated), and 3% or 10% NMP gel-treated groups. Measurements of wound areas and microscopic analyses (HE [hematoxylin-eosin] and PSR [picrosirius red] stainings) were carried out, at the 7th and 12th, days after the wound induction. Furthermore, immunohistochemical assays for iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2) and biochemical measurements for TBARS (thiobarbituric acid reactive substances), GSH (glutathione), and myeloperoxidase (MPO) were also performed, at the second day after the wound induction. The work showed that NMP decreases the wound areas, after topical application, relatively to the Sham and Control groups. In addition, microscopic alterations were reduced and collagen deposition was increased, at the 7th and 12th days, in the 10% NMP group. While iNOS and COX-2 immunostainings and GSH contents increased, in relation to the Sham and Control groups, TBARS and MPO decreased. Altogether, the results showed NMP to improve the wound healing process, by upregulating iNOS and COX-2 activities, reducing lipid peroxidation and MPO activity, and increasing GSH contents. In addition, NMP certainly contributes to the increased collagen deposition. These data may stimulate translational studies dealing with the possible use of NMP from Sideroxylon obtusifolium or from other sources for the management of wound healing.

Effective Reduction of Gastric Cancer Risk With Regular Use of Nonsteroidal Anti-Inflammatory Drugs in Helicobacter Pylori–Infected Patients

2010 ◽  
Vol 28 (18) ◽  
pp. 2952-2957 ◽  
Author(s):  
Chun-Ying Wu ◽  
Ming-Shiang Wu ◽  
Ken N. Kuo ◽  
Chang-Bi Wang ◽  
Yi-Ju Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Protective Factor ◽  
Nsaid User ◽  
Gastric Ulcers ◽  
Number Needed To Treat ◽  
Peptic Ulcers ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
H Pylori

Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) play protective roles in gastric carcinogenesis. However, the interaction between NSAIDs and Helicobacter pylori (H pylori) infection and the number needed to treat to prevent gastric cancer remains unclear. Patients and Methods We conducted a nationwide retrospective cohort study based on data from the Taiwan National Health Insurance Database. Hospitalized patients with a primary diagnosis of peptic ulcer disease were selected. Overall, 52,161 patients were divided into non-NSAID user and regular NSAID user cohorts. Standardized incidence ratios (SIRs), cumulative incidences, and hazard ratios (HRs) were calculated. Results Patients with peptic ulcers who never used NSAIDs had higher risk of gastric cancer compared with the general population (SIR, 2.11; 95% CI, 2.07 to 2.15), but regular NSAID use conferred lower risk (SIR, 0.79; 95% CI, 0.77 to 0.81). The protective role of NSAID use was observed in patients with gastric ulcer, but not in patients with non–H pylori-associated duodenal ulcer. On multivariate analysis, regular NSAID use was an independent protective factor for gastric cancer development (HR, 0.79 for each incremental year; P < .001), especially in H pylori-associated patients (HR, 0.52 for each incremental year; P < .001). Among patients with H pylori-infected gastric ulcers, the NNT to prevent a gastric cancer was 50. Conclusion Regular NSAID use may be a feasible way to prevent gastric cancer, at least in patients with gastric ulcers, and especially in H pylori-infected subjects.

scholarly journals Antibacterial and anti-inflammatory activity of extracts and major constituents derived from Stachytarpheta indica Linn. leaves and their potential implications for wound healing

2021 ◽  
Author(s):  
Vajira Asela Agampodi ◽  
Peter Katavic ◽  
Christopher Collet ◽  
Trudi Collet
Keyword(s):  
Wound Healing ◽  
Plant Extracts ◽  
Colorimetric Assay ◽  
Morphological Changes ◽  
Healing Process ◽  
Human Keratinocytes ◽  
Wound Healing Process ◽  
Keratinocyte Proliferation ◽  
Anti Inflammatory ◽  
Treatment Of Wounds

Abstract Wounds of various types continue to have a severe socioeconomic impact on the cost of health care. Globally, there has been increased interest surrounding the identification of bioactive compounds that promote or modulate the wound healing process. Stachytarpheta indica Linn. is traditionally used to heal wounds and relieve inflammation, however, the theorised pharmacological properties have not yet been scientifically validated. In this study, dried and ground plant leaves were extracted with water and methanol, which were then subjected to various analyses. Antimicrobial activity of the plant extracts and isolated compounds was determined using well diffusion assays, while the minimum inhibitory concentrations were determined with a colorimetric assay. Morphological changes of human keratinocytes in response to plant extracts were observed with differential interference contrast microscope imaging. Cell viability, proliferation and migratory effects post-treatment with the plant extracts were also evaluated via colorimetric cytotoxicity assays and a real-time cell analyser protocol. Anti-inflammatory effects of plant extracts and isolated compounds were evaluated by flow cytometry and cyclooxygenase and lipoxygenase enzyme inhibition assays. Three active compounds i.e. ipolamiide, verbascoside and iso-verbascoside, were isolated from S. indica leaves. Verbascoside demonstrated broad-range antibacterial activity and imposed strong inhibition at 9.77 μg/mL against Staphylococci spp. S. indica extracts (0.1-0.2 mg/mL) were shown to improve human keratinocyte proliferation up to 60 % and induce morphological changes by producing cytoplasmic projections at concentrations higher than 0.4 mg/mL. Plant extracts (6.25-100 μg/mL) and individual compounds (3.125-50 μg/mL) elicited strong anti-inflammatory effects by suppressing the expression of interleukin-8 and inhibiting cyclooxygenase-1 and 5-lipoxygenase enzymes. Collectively, these results indicate that plant extracts and isolated compounds derived from S. indica have the potential to inhibit bacterial growth, promote tissue regeneration and reduce inflammation, hence, potentially providing the basis for a novel therapeutic for the treatment of wounds.

scholarly journals Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review

2021 ◽  
Vol 11 (4) ◽  
pp. 1713
Author(s):  
Ilenia De Luca ◽  
Parisa Pedram ◽  
Arash Moeini ◽  
Pierfrancesco Cerruti ◽  
Gianfranco Peluso ◽  
...  
Keyword(s):  
Wound Healing ◽  
Essential Oils ◽  
Wound Dressing ◽  
Healing Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Efficient Treatment ◽  
Anti Inflammatory ◽  
Dressing Materials ◽  
Wound Dressing Materials

Wound healing refers to the replacement of damaged tissue through strongly coordinated cellular events. The patient’s condition and different types of wounds complicate the already intricate healing process. Conventional wound dressing materials seem to be insufficient to facilitate and support this mechanism. Nanotechnology could provide the physicochemical properties and specific biological responses needed to promote the healing process. For nanoparticulate dressing design, growing interest has focused on natural biopolymers due to their biocompatibility and good adaptability to technological needs. Polysaccharides are the most common natural biopolymers used for wound-healing materials. In particular, alginate and chitosan polymers exhibit intrinsic antibacterial and anti-inflammatory effects, useful for guaranteeing efficient treatment. Recent studies highlight that several natural plant-derived molecules can influence healing stages. In particular, essential oils show excellent antibacterial, antifungal, antioxidant, and anti-inflammatory properties that can be amplified by combining them with nanotechnological strategies. This review summarizes recent studies concerning essential oils as active secondary compounds in polysaccharide-based wound dressings.

scholarly journals The Wound-Healing Effect of Mango Peel Extract on Incision Wounds in a Murine Model

Molecules ◽  
2022 ◽  
Vol 27 (1) ◽  
pp. 259
Author(s):  
Lesslie Espinosa-Espinosa ◽  
Leticia Garduño-Siciliano ◽  
Mario Rodriguez-Canales ◽  
Luis Barbo Hernandez-Portilla ◽  
Maria Margarita Canales-Martinez ◽  
...  
Keyword(s):  
Wound Healing ◽  
Histological Analysis ◽  
Mangifera Indica ◽  
Normal Skin ◽  
Healing Process ◽  
Antibacterial Activities ◽  
Wound Contraction ◽  
Wound Healing Process ◽  
Mango Peel ◽  
Anti Inflammatory

Mangifera indica can generate up to 60% of polluting by-products, including peels. However, it has been shown that flavonoids and mangiferin are mainly responsible for the antioxidant, anti-inflammatory, and antibacterial activities closely related to the wound-healing process. The chemical composition of MEMI (methanolic extract of M. indica) was analyzed by HPLC-DAD, as well as concentrations of total phenol (TPC) and flavonoids (TFC) and antioxidant activity (SA50). Wound-healing efficacy was determined by measurements of wound contraction, histological analysis, and tensiometric method; moreover, anti-inflammatory, antibacterial, and acute dermal toxicity (OECD 402) were also evaluated. Phenol, resorcinol, conjugated resorcinol, and mangiferin were detected. TPC, TFC, and SA50 were 136 mg GAE/g, 101.66 mg QE/g, and 36.33 µg/mL, respectively. Tensile strength and wound contraction closure did not show significant differences between MEMI and dexpanthenol groups. Histological analysis (after 14 days) shows a similar architecture between MEMI treatment and normal skin. MEMI exhibits a reduction in edema. Staphylococcus epidermidis had an MIC of 2 mg/mL, while Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli reached 4 mg/mL. The MEMI showed no signs of toxicity. Therefore, this study demonstrates multiple targets that flavonoids and mangiferin of MEMI may present during the healing process.

scholarly journals Anti Inflammatory Effect Of Toman Fish (Channa micropeltes) Extract In Wound Healing Process

2018 ◽  
Vol 14 (2) ◽  
pp. 83
Author(s):  
Maharani Laillyza Apriasari ◽  
Dewi Puspitasari ◽  
Amy Nindia Carabelly
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Healing Process ◽  
Positive Control ◽  
Positive Control Group ◽  
Control Group ◽  
Wound Healing Process ◽  
Inflammatory Phase ◽  
Anti Inflammatory ◽  
Inflammatory Effect

 Abstract: One phase of wound healing is the inflammatory phase. Haruan fish extract has shown to accelerate the healing process up because it has anti-inflammatory effects. Toman fish originates from the same genus as the Haruan fish, but its anti-inflammatory effect remains unknown. It was done to analyzed anti-inflammatory effects of Toman fish extract. This study was true experimental design with posttest-only control design. Twenty-seven male mice of Balb-C strain were divided into 3 groups. Incision wound of 1 cm was made along the back of the mice. Nine mice in each group were sacrificed on 3rd days, then histopathology examination was conducted with Haematoxylin eosin. There were significant differences between treatment group given Toman fish extract and positive control group given Haruan fish extract, and also compared to the negative control group in PMN cell examination. There were significant differences between treatment group given Toman fish extract and positive control group given Haruan fish extract compared to negative controls on the number of macrophage cells. Toman fish extract could lower the number of PMN cells and was able to increase the number of macrophages on the 3rd days. Toman fish has anti-inflammatory effects on the wound healing process. Keywords: Anti-inflammatory effects, haruan fish extract, macrophages, PMN cells, toman fish extract

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