scholarly journals Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review

2021 ◽  
Vol 11 (4) ◽  
pp. 1713
Author(s):  
Ilenia De Luca ◽  
Parisa Pedram ◽  
Arash Moeini ◽  
Pierfrancesco Cerruti ◽  
Gianfranco Peluso ◽  
...  
Keyword(s):  
Wound Healing ◽  
Essential Oils ◽  
Wound Dressing ◽  
Healing Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Efficient Treatment ◽  
Anti Inflammatory ◽  
Dressing Materials ◽  
Wound Dressing Materials

Wound healing refers to the replacement of damaged tissue through strongly coordinated cellular events. The patient’s condition and different types of wounds complicate the already intricate healing process. Conventional wound dressing materials seem to be insufficient to facilitate and support this mechanism. Nanotechnology could provide the physicochemical properties and specific biological responses needed to promote the healing process. For nanoparticulate dressing design, growing interest has focused on natural biopolymers due to their biocompatibility and good adaptability to technological needs. Polysaccharides are the most common natural biopolymers used for wound-healing materials. In particular, alginate and chitosan polymers exhibit intrinsic antibacterial and anti-inflammatory effects, useful for guaranteeing efficient treatment. Recent studies highlight that several natural plant-derived molecules can influence healing stages. In particular, essential oils show excellent antibacterial, antifungal, antioxidant, and anti-inflammatory properties that can be amplified by combining them with nanotechnological strategies. This review summarizes recent studies concerning essential oils as active secondary compounds in polysaccharide-based wound dressings.

scholarly journals Collagen-Based Nanofibers for Skin Regeneration and Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4368
Author(s):  
Zintle Mbese ◽  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Cellular Proliferation ◽  
Healing Process ◽  
Skin Regeneration ◽  
Wound Dressings ◽  
Wound Management ◽  
Major Constituent ◽  
Wound Healing Process ◽  
Frequent Change

Skin regeneration after an injury is very vital, but this process can be impeded by several factors. Regenerative medicine is a developing biomedical field with the potential to decrease the need for an organ transplant. Wound management is challenging, particularly for chronic injuries, despite the availability of various types of wound dressing scaffolds in the market. Some of the wound dressings that are in clinical practice have various drawbacks such as poor antibacterial and antioxidant efficacy, poor mechanical properties, inability to absorb excess wound exudates, require frequent change of dressing and fails to offer a suitable moist environment to accelerate the wound healing process. Collagen is a biopolymer and a major constituent of the extracellular matrix (ECM), making it an interesting polymer for the development of wound dressings. Collagen-based nanofibers have demonstrated interesting properties that are advantageous both in the arena of skin regeneration and wound dressings, such as low antigenicity, good biocompatibility, hemostatic properties, capability to promote cellular proliferation and adhesion, and non-toxicity. Hence, this review will discuss the outcomes of collagen-based nanofibers reported from the series of preclinical trials of skin regeneration and wound healing.

scholarly journals Current Trends in Advanced Alginate-Based Wound Dressings for Chronic Wounds

2021 ◽  
Vol 11 (9) ◽  
pp. 890
Author(s):  
Andreea Barbu ◽  
Bogdan Neamtu ◽  
Marius Zăhan ◽  
Gabriela Mariana Iancu ◽  
Ciprian Bacila ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Inflammation ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Healing Process ◽  
Wound Dressings ◽  
In Vivo Studies ◽  
Public Health Issue ◽  
Wound Healing Process ◽  
Special Importance

Chronic wounds represent a major public health issue, with an extremely high cost worldwide. In healthy individuals, the wound healing process takes place in different stages: inflammation, cell proliferation (fibroblasts and keratinocytes of the dermis), and finally remodeling of the extracellular matrix (equilibrium between metalloproteinases and their inhibitors). In chronic wounds, the chronic inflammation favors exudate persistence and bacterial film has a special importance in the dynamics of chronic inflammation in wounds that do not heal. Recent advances in biopolymer-based materials for wound healing highlight the performance of specific alginate forms. An ideal wound dressing should be adherent to the wound surface and not to the wound bed, it should also be non-antigenic, biocompatible, semi-permeable, biodegradable, elastic but resistant, and cost-effective. It has to give protection against bacterial, infectious, mechanical, and thermal agents, to modulate the level of wound moisture, and to entrap and deliver drugs or other molecules This paper explores the roles of alginates in advanced wound-dressing forms with a particular emphasis on hydrogels, nanofibers networks, 3D-scaffolds or sponges entrapping fibroblasts, keratinocytes, or drugs to be released on the wound-bed. The latest research reports are presented and supported with in vitro and in vivo studies from the current literature.

scholarly journals Developmental prospectives of new generation super absorbent wound dressing materials from sulfated polysaccharide of marine red algae

2021 ◽  
Vol 23 (09) ◽  
pp. 400-408
Author(s):  
Amruth P ◽  
◽  
Amruth P ◽  
Rosemol Jacob M ◽  
Suseela Mathew ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Antimicrobial Agents ◽  
Wound Care ◽  
Healing Process ◽  
Cost Effective ◽  
Sulfated Polysaccharide ◽  
Wound Dressings ◽  
New Generation ◽  
Dressing Materials ◽  
Wound Dressing Materials

Wound healing remains as a dynamic process and the type of dressing material significantly affects the efficacy of healing. The identification of ideal dressings to use for a particular wound type is an important requisite facilitating the entire process of healing. Chronic, high exudate wounds are dynamic in presentation and remain as a major health care burden. Researchers have sort to design and optimize biodegradable wound dressings that focuses to optimize moisture retentiveness, as superior character in the healing process. In addition, dressings have been designed to visualize the wound bed by improving the optical property, target and kill infection-causing bacteria, with the incorporation of antimicrobial agents, nanomaterials and numerous other measures. For the practitioners, choosing the optimal dressing decreases time to healing, provides cost-effective care and improves patient quality of life. The current mini review highlights the ideal characters of wound dressing materials and presents insights on the superior characters of carrageenan bio composites for prospective advancements in research in the area of wound care and management.

Preparation and in vivo evaluation of a novel gel-based wound dressing using arginine–alginate surface-modified chitosan nanofibers

2017 ◽  
Vol 32 (6) ◽  
pp. 689-701 ◽  
Author(s):  
Mahsa Hoseinpour Najar ◽  
Mohsen Minaiyan ◽  
Azade Taheri
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Healing Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
In Vivo Evaluation ◽  
Animal Group ◽  
Modified Chitosan ◽  
Surface Modified

The development of an effective wound dressing with the ability to induce skin wound healing is a great challenge in medicine. Nanofibers are highly attractive for wound dressing preparation due to their properties such as hemostasis induction, good absorption of wound exudates, and facilitation of cell growth. Chitosan nanofibers have attracted great attention for application in wound dressings due to their accelerating effects on wound healing. In this study, arginine surface-modified chitosan nanofibers were successfully prepared by attachment of arginine molecules on the surface of chitosan nanofibers using sodium alginate through electrostatic interaction. The effect of pH on the amount of attached arginine was evaluated at three different pH values; 5, 6, and 7. Fourier-transform infrared spectroscopy and zeta potential of chitosan nanofibers before and after surface modification suggested the occurrence of the attachment of arginine to chitosan nanofibers. Scanning electron microscope images showed the nanofibrous structure of arginine surface-modified chitosan nanofibers with an average diameter ranging from 100 nm to 150 nm. The release of arginine from arginine surface-modified chitosan nanofibers gel showed a sustained release manner. The suitable viscosity and spreadability of arginine surface-modified chitosan nanofibers gel verified its easy application at the wound site. Arginine surface-modified chitosan nanofibers gel significantly improved the wound healing process including wound closure when tested in vivo using rat model. Additionally, histological examination and immunohistochemical studies showed the significant enhancement of the re-epithelialization, collagen deposition, and angiogenesis in the skin of the animal group treated with arginine surface-modified chitosan nanofibers gel compared with the other control groups. These results suggested that arginine surface-modified chitosan nanofibers gel could be introduced as an effective wound dressing.

Evaluation of a novel bioactive wound dressing: an in vitro and in vivo study

2021 ◽  
Vol 30 (6) ◽  
pp. 482-490
Author(s):  
Fahimeh Farshi Azhar ◽  
Paria Rostamzadeh ◽  
Monireh Khordadmehr ◽  
Mehran Mesgari-Abbasi
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Healing Process ◽  
Wound Dressings ◽  
Bilayer Film ◽  
Wound Healing Process ◽  
Tissue Contraction ◽  
Experimental Rat Model

Objective: Hard-to-heal wounds, such as pressure ulcers and diabetic ulcers, are a major challenge for wound dressings. The aim of this study was to develop a bioactive dressing based on polymers and natural materials with unique biological and therapeutic properties. Method: The dressing was composed of an active layer containing polyvinyl alcohol (PVA), honey, curcumin and keratin, and an upper layer with lower hydrophilicity comprising PVA to induce flexibility. Physicochemical properties of the dressing were characterised by Fourier transform infrared spectroscopy, field emission scanning electron microscopy, swelling behaviour and antibacterial measurements. A wound healing study was performed using an experimental rat model and two different compositions of the bioactive dressing were compared with a commercial wound dressing (Comfeel, Coloplast, Denmark). Histopathological evaluation was conducted for this purpose. Results: Characterisation results showed that a smooth bilayer film with two homogenous but distinct layers was produced. The dressing also provided adequate moisture to the wound environment without infection and adhesion due to dryness occurring. Our results exhibited significant bactericidal activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria and improved the wound healing process without any scarring. Histopathological findings demonstrated a significant higher healing rate in vivo together with well-formed epidermis, granulation tissue formation and tissue contraction, when compared with the commercial wound dressing. Conclusion: Our results demonstrated acceptable physical and healing effects for the novel bioactive wound dressing; however, more investigations are recommended.

Electrospinning nanofibrous graft preparation and wound healing studies using ZnO nanoparticles and glucosamine loaded with poly(methyl methacrylate)/polyethylene glycol

2021 ◽  
Author(s):  
Suganya Bharathi Balakrishnan ◽  
Manawwer Alam ◽  
Naushad Ahmad ◽  
Manikandan Govindasamy ◽  
Sakthivelu Kuppu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Polyethylene Glycol ◽  
Zno Nanoparticles ◽  
Wound Dressing ◽  
Antioxidant Properties ◽  
Wound Dressings ◽  
Nanofibrous Scaffolds ◽  
Successful Technique ◽  
Dressing Materials ◽  
Wound Dressing Materials

As wound dressing materials, electrospun nanofibrous scaffolds have a lot of promise. Electrospun nanofibrous scaffolds in combination with ZnO nanoparticles have antimicrobial and antioxidant properties, making electrospinning a successful technique for wound dressings.

scholarly journals Recent Updates on Biopolymers based Wound Dressings

2021 ◽  
Vol 33 (7) ◽  
pp. 1457-1470
Author(s):  
Sonia Arora ◽  
Manju Nagpal ◽  
Malkiet Kaur
Keyword(s):  
Extracellular Matrix ◽  
Wound Dressing ◽  
Low Cost ◽  
Healing Process ◽  
Synthetic Polymer ◽  
Wound Dressings ◽  
Naturally Occurring ◽  
Current Review ◽  
Dressing Materials ◽  
Wound Dressing Materials

Wound dressing is designed to support the wound bed and protect it from the factors that may delay or impede its healing such as contamination and moisture thereby facilitating and accelerate the healing process. The material used to prepare wound dressing include natural and synthetic polymer as their combination in the form of film and sponges that may be extensively used in wound dressing material. Naturally occurring polymers having many importance because of high biocompatibility and environmentally finding properties. Polysaccharides are naturally occurring polymers that have been extensively used as wound dressing materials. Homopolysaccharide are a class of polysaccharides consists of only one type of monosaccharide. Naturally occurring polymers are used for wound dressing properties because of their extracellular matrix as good acceptance by biological system. Polysaccharide is type of naturally occurring polymers that offer the advantage of good hemocompatibility and low cost in comparison with other biopolymers. The current review intends to overview the studies in which wound dressings from naturally-occurring polymers including chitosan, silk fibroin, sodium alginate and hyaluronic acid were considered.

Cerium-oxide-loaded poly(ɛ-caprolactone) hydrogel wound dressing for cutaneous wound healing and antimicrobial treatment in burn wound infection: Development and detailed biological evaluation

2021 ◽  
Vol 11 (12) ◽  
pp. 1966-1974
Author(s):  
Wei Wei ◽  
Liang Xing ◽  
Jianke Feng
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Care Management ◽  
Metal Oxide Nanoparticles ◽  
Healing Process ◽  
Biological Evaluation ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Dressing Materials ◽  
Wound Dressing Materials

Wound dressing materials are essential in wound healing care management. In addition to their supportive effect on the care management, polysaccharides and metal oxide nanoparticles actively contribute to the healing process. CeO2 nanoparticles can promote wound healing through oxidative damage in the wound environment against elevated levels of reactive oxygen species. Therefore, it is necessary to develop multi-functional hydrogel wound dressing materials to stimulate wound healing. In this study, a CeO2-loaded poly(ɛ-caprolactone)/PEC polymeric hydrogel was fabricated as a cutaneous wound-healing material. The in-vitro cytotoxic and wound healing activities were analyzed using the fabricated material in mice. A histological examination showed that the nanofibrous material accelerated the reepithelialization and provided an excellent collagen deposition. In addition, the prepared hydrogels were tested against S. aureus and E. coli. Our results evidence the unique characteristics of the hydrogel wound dressing material exhibiting antibacterial and antioxidant activities and good biocompatibility and healing efficiencies by enhancing the reepithelialization and granulation formation and effectively accelerating the wound healing to prevent skin infections.

scholarly journals Macrophage immunomodulation: An indispensable tool to evaluate the performance of wound dressing biomaterials

2019 ◽  
Vol 17 (1) ◽  
pp. 228080001983035 ◽  
Author(s):  
Patrícia Varela ◽  
Susanna Sartori ◽  
Richard Viebahn ◽  
Jochen Salber ◽  
Gianluca Ciardelli
Keyword(s):  
Wound Healing ◽  
Immune Cells ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Macrophage Polarization ◽  
Healing Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Immunomodulatory Effects ◽  
Wide Range

A major burden of the healthcare system resides in providing proper medical treatment for all types of chronic wounds, which are usually treated with dressings to induce a faster regeneration. Hence, to reduce healing time and improve the patient’s quality of life, it is extremely important to select the most appropriate constituent material for a specific wound dressing. A wide range of wound dressings exist but their mechanisms of action are poorly explored, especially concerning the immunomodulatory effects that occur from the interactions between immune cells and the biomaterial. Tissue-resident and monocyte-derived recruited macrophages are key regulators of wound repair. These phagocytic immune cells exert specific functions during the different stages of wound healing. The recognition of the substantial role of macrophages in the outcome of the wound healing process requires specific understanding of the immunomodulatory effects of commercially available or newly developed wound dressings. For a precise intervention, it is necessary to obtain more knowledge on macrophage polarization in different phases of wound healing in the presence of the dressings. The main purpose of this review is to collect clinical cases in which macrophage immunomodulation was taken into consideration as an indicator of the performances of novel or mainstream wound dressing materials, including those provided with antimicrobial properties.

scholarly journals Starch/hyaluronic acid/sorbitol composite films as potential wound dressing materials that protect against P. Aeruginosa

2019 ◽  
Vol 10 (SPL1) ◽  
Author(s):  
R. M. Zaki ◽  
K. Ramasamy ◽  
R. K. Mishra ◽  
A. B. A. Majeed ◽  
S. M. Lim
Keyword(s):  
Hyaluronic Acid ◽  
Bacterial Infection ◽  
Wound Dressing ◽  
Healing Process ◽  
Composite Films ◽  
Antibacterial Properties ◽  
Wound Healing Process ◽  
Protection Against Infection ◽  
Dressing Materials ◽  
Wound Dressing Materials

Bacterial infection is one of the key challenges to the wound healing process. Ideal wound dressing materials should, therefore, be able to inhibit bacterial infection. The present study evaluated the antibacterial properties of composite films for use as wound dressing materials. The composite films, which were made up of starch, sodium hyaluronic acid (SHA), and sorbitol, were prepared at varying concentrations of hyaluronic acid (25-100mg) by solvent casting method. The composite films were tested against gram-negative Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhimurium as well as gram-positive Staphylococcus aureus for 24 hours by using the disc diffusion assay. Chloramphenicol and ciprofloxacin were included as positive controls. Amongst the tested pathogens, composite films with SHA > 25mg inhibited only P. aeruginosa. It is noteworthy that the antibacterial effect of composite films with SHA > 50mg were comparable to those of chloramphenicol and ciprofloxacin. The present findings implied the possible incorporation of starch/ hyaluronic acid/ sorbitol composite films as part of wound dressing for protection against infection caused by P. aeruginosa.

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