scholarly journals Synthesis and Antibacterial Activity of Novel Vanillic Acid Hybrid Derivatives [Part II]

2018 ◽  
pp. 219-223 ◽  
Author(s):  
Maruti S. Satpute ◽  
Vijay D. Gangan ◽  
Indu Shastri
Keyword(s):  
Antibacterial Activity ◽  
Vanillic Acid ◽  
Chemotherapeutic Agents ◽  
Active Pharmaceutical Ingredients ◽  
Dihydroxybenzoic Acid ◽  
Drug Candidates ◽  
Pharmaceutical Ingredients ◽  
Derivatives Of ◽  
Flavoring Agent ◽  
Methoxybenzoic Acid

Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a dihydroxybenzoic acid derivative used as a flavoring agent. It is used in the synthesis of various active pharmaceutical ingredients such as Etamivan, Modecainide, Brovanexine, Vanitiolide, Vanyldisulfamide etc. In this paper, novel ester / hybrid derivatives of vanillic acid were synthesized and tested for potential antibacterial activity. This combinatorial synthesis of novel vanillic ester / hybrid derivatives can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates.

scholarly journals Methyl Vanillate Ether Derivatives as Future Potential Drug

2019 ◽  
pp. 129-134
Author(s):  
Maruti S. Satpute ◽  
Vijay D. Gangan ◽  
Indu Shastri
Keyword(s):  
Vanillic Acid ◽  
Chemotherapeutic Agents ◽  
Combinatorial Synthesis ◽  
Active Pharmaceutical Ingredients ◽  
Dihydroxybenzoic Acid ◽  
Drug Candidates ◽  
Pharmaceutical Ingredients ◽  
Future Potential ◽  
Derivatives Of ◽  
Methoxybenzoic Acid

Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a dihydroxybenzoic acid derivative used as a flavouring agent. It is used in the synthesis of various active pharmaceutical ingredients such as Etamivan, Modecainide, Brovanexine, Vanitiolide, Vanyldisulfamide etc. In this paper, novel ether derivatives of vanillic acid were synthesized and tested for potential antibacterial activity. This combinatorial synthesis of novel vanillic acid ether derivatives can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates.

scholarly journals A Review of the Pharmacological Characteristics of Vanillic Acid

2021 ◽  
Vol 11 (2-S) ◽  
pp. 200-204
Author(s):  
Ashwini Ingole ◽  
Megha P Kadam ◽  
Aishwarya P. Dalu ◽  
Shital M Kute ◽  
Piyusha R Mange ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vanillic Acid ◽  
The Other ◽  
Pharmacological Properties ◽  
Dihydroxybenzoic Acid ◽  
Acid Analog ◽  
Effective Antioxidant ◽  
Pharmacological Potential ◽  
Flavoring Agent ◽  
Methoxybenzoic Acid

A dihydroxybenzoic acid analog used as a flavoring agent is vanillic acid (4hydroxy-3-methoxybenzoic acid). It's a form of vanillin that has been oxidized. It's also a step in the process of making vanillin from Ferulic Acid. Vanillic acid has seen a lot of press because of its many uses in the cosmetics, fruit, flavorings, cigarettes,alcohols, drinks, and polymer sectors. It's said to have effective antioxidant, anti-inflammatory, and neuroprotective properties. The pharmacological impact on oxidative stress-induced neuro-degeneration, on the other hand, have not been thoroughly examined. The pharmacological properties of vanillic Acid lead to its possible use in the treatment of various diseases. Keywords: Vanillic acid, Pharmacological Potential, wound healing, Antioxidants

scholarly journals Synthesis and Antibacterial Activity of Novel 3-Hydroxy Benzoic Acid Hybrid Derivative [Part I]

2018 ◽  
pp. 369-374
Author(s):  
Maruti S. Satpute ◽  
Vijay D. Gangan ◽  
Indu Shastri
Keyword(s):  
Antibacterial Activity ◽  
Benzoic Acid ◽  
Direct Action ◽  
Biological Properties ◽  
Chemotherapeutic Agents ◽  
Organic Chemical ◽  
Cell Disease ◽  
Drug Candidates ◽  
Derivatives Of ◽  
Hybrid Derivative

3-hydroxy benzoic acid is an organic chemical which can be obtained naturally as well as synthetically. The literature survey reveals its various biological properties viz. antimicrobial, antialgal, antimutagenic, antiestrogenic, hypoglycemic, anti-inflammatory, anti-platelet aggregating, nematicidal, antiviral, antioxidant etc. It is also reported to be used as preservative in many drugs, cosmetic products, pharmaceuticals, food and beverages. Some derivatives of 3-hydroxybenzoic acid are found to possess direct action on Hbs molecules, inhibit acetic acid induced oedema and used in management of sickle cell disease. It is also has wide applications in perfumery industries. In this paper, novel ester / hybrid derivative of 3- Hydroxy benzoic acid was synthesized and tested for its potential antibacterial activity. This combinatorial synthesis of novel 3-Hydroxy benzoic ester / hybrid derivative can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates.

scholarly journals The Lisbon Supramolecular Green Story: Mechanochemistry towards New Forms of Pharmaceuticals

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2705
Author(s):  
João Luís Ferreira da Silva ◽  
M. Fátima Minas da Piedade ◽  
Vânia André ◽  
Sofia Domingos ◽  
Inês C. B. Martins ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Physicochemical Properties ◽  
Mechanochemical Synthesis ◽  
Crystal Engineering ◽  
Short Review ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Polymorphic Forms ◽  
Derivatives Of

This short review presents and highlights the work performed by the Lisbon Group on the mechanochemical synthesis of active pharmaceutical ingredients (APIs) multicomponent compounds. Here, we show some of our most relevant contributions on the synthesis of supramolecular derivatives of well-known commercial used drugs and the corresponding improvement on their physicochemical properties. The study reflects, not only our pursuit of using crystal engineering principles for the search of supramolecular entities, but also our aim to correlate them with the desired properties. The work also covers our results on polymorphic screening and describes our proposed alternatives to induce and maintain specific polymorphic forms, and our approach to avoid polymorphism using APIs as ionic liquids. We want to stress that all the work was performed using mechanochemistry, a green advantageous synthetic technique.

Preparation of esterified derivatives of α-lactalbumin and investigation of their antibacterial activity

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Negar Ghorbani ◽  
Abdol-Khalegh Bordbar ◽  
Asghar Taheri-Kafrani ◽  
Akbar Vaseghi
Keyword(s):  
Antibacterial Activity ◽  
Derivatives Of

Reversed-Phase High Performance Liquid Chromatographic Analysis of Three First Line Anti-Tuberculosis Drugs

2019 ◽  
Vol 69 (12) ◽  
pp. 3590-3592
Author(s):  
Nela Bibire ◽  
Romeo Iulian Olariu ◽  
Luminita Agoroaei ◽  
Madalina Vieriu ◽  
Alina Diana Panainte ◽  
...  
Keyword(s):  
High Performance ◽  
Biological Fluids ◽  
Gradient Elution ◽  
High Performance Liquid Chromatographic ◽  
Reversed Phase ◽  
Assay Method ◽  
Active Pharmaceutical Ingredients ◽  
First Line ◽  
Pharmaceutical Ingredients ◽  
Liquid Chromatographic

Active pharmaceutical ingredients such as isoniazid, pyrazinamide and rifampicin are among the most important first-line anti-tuberculosis drugs. A simple, rapid and sensitive reversed phase-high performance liquid chromatographic assay method for the simultaneous determination of isoniazid, pyrazinamide and rifampicin has been developed. Separation of the interest compounds was achieved in a 10 min chromatographic run in gradient elution mode on a Zorbax SB-C18 stainless steel column (150 � 4 mm, 5 mm) using a guard column containing the same stationary phase. The gradient elution was carried out with a mobile phase of 10% CH3CN aqueous solution for channel A and 50% CH3CN in pH = 6.8 phosphate buffer (20 mM), to which 1.5 mL triethylamine were added for channel B. Quantification of the analyzed substances was carried out spectrophotometrically at 269 nm. Detection limits of 0.48 mg/L for isoniazid, 0.52 mg/L for pyrazinamide and 0.48 mg/L for rifampicin were established for the developed assay method. The present work showed that the proposed analysis method was advantageous for simple and rapid analysis of the active pharmaceutical ingredients in pharmaceuticals and biological fluids.

Synthesis and Evaluation of Aromatic Surfactants as Potential Antibacterial and Cytotoxic Agents

2019 ◽  
Vol 16 (6) ◽  
pp. 478-484
Author(s):  
Kenia Barrantes ◽  
Mary Fuentes ◽  
Luz Chacón ◽  
Rosario Achí ◽  
Jorge Granados-Zuñiga ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Hela Cells ◽  
Cytotoxic Agents ◽  
Cytotoxic Activities ◽  
Hydroxybenzoic Acid ◽  
Derivatives Of

Two ether and one ester derivatives of the 4-nitro-3-hydroxybenzoic acid were synthesized and characterized. The in vitro antimicrobial and cytotoxic activities of the three novel compounds were also evaluated. The aromatic derivatives showed antibacterial activity against one of the four microorganisms tested and two compounds (C8 and NOBA) had a lower IC50 in HeLa cells.

The Effect of N-4 Substituent on Antibacterial Activity of Novel Hydroxymethyl/Aminomethyl Derivatives of 1,2,4-Triazole-3-thione

2012 ◽  
Vol 9 (6) ◽  
pp. 633-637 ◽  
Author(s):  
Tomasz Plech ◽  
Monika Wujec ◽  
Urszula Kosikowska ◽  
Anna Malm ◽  
Magdalena Barylka ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Aminomethyl Derivatives ◽  
Derivatives Of
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