scholarly journals The use of analytical methods for quality control of promising active pharmaceutical ingredients among derivatives of 4-oxoquinoline- 3-propanoic acids

2016 ◽  
Vol 0 (4(88)) ◽  
pp. 22-30
Author(s):  
V. O. Zubkov ◽  
N. I. Ruschak ◽  
M. M. Suleiman ◽  
A. O. Devyatkіna ◽  
I. S. Gritsenko
Keyword(s):  
Quality Control ◽  
Analytical Methods ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Derivatives Of

Analytical Methods of Dihydropyridines Based Calcium Channel Blockers - Amlodipine, Lacidipine, Isradipine, Nifedipine, Felodipine, Cilnidipine and its related formulations: A Review

2021 ◽  
pp. 221-234
Author(s):  
Pankaj Kisan Chatki ◽  
Sana Tabassum
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Analytical Methods ◽  
Biological Fluids ◽  
Analytical Techniques ◽  
Channel Blockers ◽  
Active Pharmaceutical Ingredients ◽  
Analytical Technique ◽  
Pharmaceutical Ingredients ◽  
Analytical Instruments

Objectives: Various analytical techniques are applied in pharmaceutical field to estimate the quality of active pharmaceutical ingredients, amount of drug in biological fluids and in formulations. The aim of this review article is to provide utmost existing analytical methods for analysis of dihydropyridines based calcium channel blockers for estimation of Amlodipine, Lacidipine, Isradipine, Nifedipine, Felodipine, and Cilnidipine in pure form, biological fluids (like Human Plasma, Human Serum, Human Urine etc.,) and its related formulations including novel formulations. Dihydropyridines based Calcium Channel blockers is a major chemical class of drugs used in the treatment of hypertension and various coronary artery diseases. Evidence acquisition: Current analytical techniques available for active pharmaceutical ingredients and its related formulations are tabulated with extensive method conditions which can be used in analysis of dihydropyridines based calcium channel blockers drugs outlined from official pharmacopoeias and other relevant research articles. Conclusion: Various analytical techniques such as HPLC, HPTLC, UPLC, GC, LC-MS, and GC-MS are involved. This review assists in appropriate selection of analytical technique, solvent, mobile phase, column, detector based on available analytical instruments and chemicals, by referring tabulated extensive method conditions. It can be implemented in quality control and quality assurance department for quality assessment of diverse pharmaceutical formulations.

Fractal Analysis of Lyophilized Active Pharmaceutical Ingredients

2020 ◽  
Vol 36 (5) ◽  
pp. 98-103
Author(s):  
I.A. Selivanova
Keyword(s):  
Quality Control ◽  
Fractal Analysis ◽  
Fractal Geometry ◽  
Pharmaceutical Analysis ◽  
Bifidobacterium Bifidum ◽  
Academic Excellence ◽  
Control Methods ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Rapid Tests

The development of effective drug quality control methods based on intelligent technologies is an urgent task for pharmaceutical analysis in the context of production robotization. This is particularly topical for biotechnology-derived pharmaceutical ingredients due to the peculiarities of the analysis of these compounds and limited number of quality control methods for drugs. Fractal geometry can be a mathematical background for the creation of such method. In this work we studied the possibility of fractal geometry using for the development of rapid tests for bifidumbacterin lyophilisates. A correlation was established between the fractal dimension of the structure of the Bifidobacterium bifidum dry mixture solids with sucrose-gelatin-milk medium and the specified pharmaceutical ingredient parameters, such as drug reconstitution time (R2=0,97) and pH (R2=0,95). This work demonstrated that fractal analysis is a promising tool for automated rapid tests of lyophilized biotechnology-derived active pharmaceutical ingredients without losing the analyzed sample. fractal analysis, pharmaceutical analysis, quality control, lyophilisates, bifidumbacterin. This work was supported by the Russian Academic Excellence Project 5-100

scholarly journals The Lisbon Supramolecular Green Story: Mechanochemistry towards New Forms of Pharmaceuticals

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2705
Author(s):  
João Luís Ferreira da Silva ◽  
M. Fátima Minas da Piedade ◽  
Vânia André ◽  
Sofia Domingos ◽  
Inês C. B. Martins ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Physicochemical Properties ◽  
Mechanochemical Synthesis ◽  
Crystal Engineering ◽  
Short Review ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Polymorphic Forms ◽  
Derivatives Of

This short review presents and highlights the work performed by the Lisbon Group on the mechanochemical synthesis of active pharmaceutical ingredients (APIs) multicomponent compounds. Here, we show some of our most relevant contributions on the synthesis of supramolecular derivatives of well-known commercial used drugs and the corresponding improvement on their physicochemical properties. The study reflects, not only our pursuit of using crystal engineering principles for the search of supramolecular entities, but also our aim to correlate them with the desired properties. The work also covers our results on polymorphic screening and describes our proposed alternatives to induce and maintain specific polymorphic forms, and our approach to avoid polymorphism using APIs as ionic liquids. We want to stress that all the work was performed using mechanochemistry, a green advantageous synthetic technique.

scholarly journals Synthesis and Antibacterial Activity of Novel Vanillic Acid Hybrid Derivatives [Part II]

2018 ◽  
pp. 219-223 ◽  
Author(s):  
Maruti S. Satpute ◽  
Vijay D. Gangan ◽  
Indu Shastri
Keyword(s):  
Antibacterial Activity ◽  
Vanillic Acid ◽  
Chemotherapeutic Agents ◽  
Active Pharmaceutical Ingredients ◽  
Dihydroxybenzoic Acid ◽  
Drug Candidates ◽  
Pharmaceutical Ingredients ◽  
Derivatives Of ◽  
Flavoring Agent ◽  
Methoxybenzoic Acid

Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a dihydroxybenzoic acid derivative used as a flavoring agent. It is used in the synthesis of various active pharmaceutical ingredients such as Etamivan, Modecainide, Brovanexine, Vanitiolide, Vanyldisulfamide etc. In this paper, novel ester / hybrid derivatives of vanillic acid were synthesized and tested for potential antibacterial activity. This combinatorial synthesis of novel vanillic ester / hybrid derivatives can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates.

scholarly journals Methyl Vanillate Ether Derivatives as Future Potential Drug

2019 ◽  
pp. 129-134
Author(s):  
Maruti S. Satpute ◽  
Vijay D. Gangan ◽  
Indu Shastri
Keyword(s):  
Vanillic Acid ◽  
Chemotherapeutic Agents ◽  
Combinatorial Synthesis ◽  
Active Pharmaceutical Ingredients ◽  
Dihydroxybenzoic Acid ◽  
Drug Candidates ◽  
Pharmaceutical Ingredients ◽  
Future Potential ◽  
Derivatives Of ◽  
Methoxybenzoic Acid

Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a dihydroxybenzoic acid derivative used as a flavouring agent. It is used in the synthesis of various active pharmaceutical ingredients such as Etamivan, Modecainide, Brovanexine, Vanitiolide, Vanyldisulfamide etc. In this paper, novel ether derivatives of vanillic acid were synthesized and tested for potential antibacterial activity. This combinatorial synthesis of novel vanillic acid ether derivatives can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates.

scholarly journals Model-Based Tools for Pharmaceutical Manufacturing Processes

Processes ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 49 ◽  
Author(s):  
René Schenkendorf ◽  
Dimitrios Gerogiorgis ◽  
Seyed Mansouri ◽  
Krist Gernaey
Keyword(s):  
Quality Control ◽  
Pharmaceutical Manufacturing ◽  
Manufacturing Processes ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Model Based ◽  
Production Processes ◽  
Highly Sensitive

Active pharmaceutical ingredients (APIs) are highly valuable, highly sensitive products resulting from production processes with strict quality control specifications and regulations that are required for the safety of patients [...]

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