Evaluation of cytotoxic potential of latex of Calotropis procera and Podophyllotoxin in Allum cepa root model

BIOCELL ◽  
2006 ◽  
Vol 30 (1) ◽  
pp. 9-13 ◽  
Author(s):  
R. SEHGAL ◽  
S. ROY ◽  
V.L. KUMAR
Keyword(s):  
Calotropis Procera ◽  
Cytotoxic Potential ◽  
Root Model

scholarly journals In vitro and in vivo antiproliferative activity of Calotropis procera stem extracts

2010 ◽  
Vol 82 (2) ◽  
pp. 407-416 ◽  
Author(s):  
Hemerson I.F. Magalhães ◽  
Paulo M.P. Ferreira ◽  
Eraldo S. Moura ◽  
Márcia R. Torres ◽  
Ana P.N.N. Alves ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Antiproliferative Activity ◽  
Calotropis Procera ◽  
Tumor Growth Inhibition ◽  
Cytotoxic Potential ◽  
Cytotoxic Compound ◽  
Antimitotic Activity ◽  
Ic50 Values

The cytotoxic potential of stem organic extracts from Calotropis procera (Asclepiadaceae) was firstly evaluated against cancer cell lines by MTT assay. Subsequently, samples considered cytotoxic were tested for antimitotic activity on sea urchin egg development and for in vivo antiproliferative activity in mice bearing Sarcoma 180 tumor. Among the five extracts (hexane, dichloromethane, ethyl acetate, acetone and methanol), ethyl acetate and acetone extracts displayed higher cytotoxic potential against tumor cells, with IC50 ranging from 0.8 to 4.4 μg/mL, while methanolic extract was weakly cytotoxic. Cytotoxic extracts also exhibited cell division inhibition capacity by antimitotic assay, revealing IC50 values lower than 5 μg/mL. In the in vivo antitumor assessments, ethyl acetate- and acetone-treated animals showed tumor growth inhibition ratios of 64.3 and 53.1%, respectively, with reversible toxic effects on liver and kidneys. Further studies are in progress in order to identify C. procera cytotoxic compound(s) and to understand the mechanism of action responsible for this tumor-decreasing potential.

Cytotoxic potential of new phenylpropanoid derivatives isolated from Nectandra leucantha Nees & Mart (Lauraceae)

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
SS Grecco ◽  
EGA Martins ◽  
CR Figueiredo ◽  
N Girola ◽  
AL Matsuo ◽  
...  
Keyword(s):  
Cytotoxic Potential ◽  
Phenylpropanoid Derivatives

Phytostabilization Ability and Growth Response of Calotropis procera and Lantana camara towards Tannery Amended Soil

2019 ◽  
Vol 35 (2) ◽  
pp. 215-224
Author(s):  
Poonam Rani ◽  
◽  
Adarsh Kumar ◽  
Ramesh Chandra Arya ◽  
◽  
...  
Keyword(s):  
Growth Response ◽  
Lantana Camara ◽  
Calotropis Procera ◽  
Amended Soil

STRUCTURAL CHARACTERIZATION AND IN VITRO CYTOTOXIC POTENTIAL OF COAL DUST IN A ROMANIAN POWER PLANT

2010 ◽  
Vol 9 (9) ◽  
pp. 1297-1304
Author(s):  
Alice Raducanu ◽  
Aurica Suvergel ◽  
George Darie ◽  
Ileana Rau ◽  
Constantin Grigoriu ◽  
...  
Keyword(s):  
Power Plant ◽  
Structural Characterization ◽  
Coal Dust ◽  
Cytotoxic Potential
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