Characterization of an in vitro neural stem cell niche with educational component : Stem cells and society

2008 ◽  
Author(s):  
Chris Pierret
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Stem Cell Niche ◽  
Neural Stem Cell Niche ◽  
Cell Niche ◽  
Educational Component

scholarly journals Histological Studies of the Ventricular–Subventricular Zone as Neural Stem Cell and Glioma Stem Cell Niche

2021 ◽  
pp. 002215542110320
Author(s):  
Asa A. Brockman ◽  
Bret C. Mobley ◽  
Rebecca A. Ihrie
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Tumor Cells ◽  
Neural Stem Cell ◽  
Subventricular Zone ◽  
Stem Cell Niche ◽  
Special Focus ◽  
Neural Stem Cell Niche ◽  
Stem And Progenitor Cells ◽  
Cell Niche

The neural stem cell niche of the ventricular–subventricular zone supports the persistence of stem and progenitor cells in the mature brain. This niche has many notable cytoarchitectural features that affect the activity of stem cells and may also support the survival and growth of invading tumor cells. Histochemical studies of the niche have revealed many proteins that, in combination, can help to reveal stem-like cells in the normal or cancer context, although many caveats persist in the quest to consistently identify these cells in the human brain. Here, we explore the complex relationship between the persistent proliferative capacity of the neural stem cell niche and the malignant proliferation of brain tumors, with a special focus on histochemical identification of stem cells and stem-like tumor cells and an eye toward the potential application of high-dimensional imaging approaches to the field.

scholarly journals 3D Reconstitution of the Neural Stem Cell Niche: Connecting the Dots

2021 ◽  
Vol 9 ◽  
Author(s):  
Konstantinos Ioannidis ◽  
Ioannis Angelopoulos ◽  
Georgios Gakis ◽  
Nikolaos Karantzelis ◽  
Georgios A. Spyroulias ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Subventricular Zone ◽  
Stem Cell Niche ◽  
Ex Vivo ◽  
Neural Cells ◽  
Neural Stem Cell Niche ◽  
Cell Niche ◽  
Connecting The Dots

Neural stem cells (NSCs) are important constituents of the nervous system, and they become constrained in two specific regions during adulthood: the subventricular zone (SVZ) and the subgranular zone (SGZ) of the dentate gyrus in the hippocampus. The SVZ niche is a limited-space zone where NSCs are situated and comprised of growth factors and extracellular matrix (ECM) components that shape the microenvironment of the niche. The interaction between ECM components and NSCs regulates the equilibrium between self-renewal and differentiation. To comprehend the niche physiology and how it controls NSC behavior, it is fundamental to develop in vitro models that resemble adequately the physiologic conditions present in the neural stem cell niche. These models can be developed from a variety of biomaterials, along with different biofabrication approaches that permit the organization of neural cells into tissue-like structures. This review intends to update the most recent information regarding the SVZ niche physiology and the diverse biofabrication approaches that have been used to develop suitable microenvironments ex vivo that mimic the NSC niche physiology.

Elements of a Neural Stem Cell Niche Derived from Embryonic Stem Cells

2007 ◽  
Vol 16 (6) ◽  
pp. 1017-1026 ◽  
Author(s):  
Chris Pierret ◽  
Kathleen Spears ◽  
Jason A. Morrison ◽  
Joel A. Maruniak ◽  
Martin L. Katz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Neural Stem Cell ◽  
Stem Cell Niche ◽  
Embryonic Stem ◽  
Neural Stem Cell Niche ◽  
Cell Niche

scholarly journals Hypothalamic Neurons Take Center Stage in the Neural Stem Cell Niche

2017 ◽  
Vol 21 (3) ◽  
pp. 293-294 ◽  
Author(s):  
Julia P. Andreotti ◽  
Luiza Lousado ◽  
Luiz Alexandre V. Magno ◽  
Alexander Birbrair
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Stem Cell Niche ◽  
Hypothalamic Neurons ◽  
Center Stage ◽  
Neural Stem Cell Niche ◽  
Cell Niche

scholarly journals Extracellular matrix and the neural stem cell niche

2011 ◽  
Vol 71 (11) ◽  
pp. 1006-1017 ◽  
Author(s):  
Ilias Kazanis ◽  
Charles ffrench-Constant
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Stem Cell Niche ◽  
Neural Stem Cell Niche ◽  
Cell Niche
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