scholarly journals The Role Of Nitric Oxide In Cancer Development & it`s Therapy

2020 ◽  
Vol 3 (1) ◽  
pp. 21-34
Author(s):  
Najlaa Qassim Muftin ◽  
Asma Jameil Al-Lamei ◽  
Suzanne Jubair ◽  
Abdalla Raied Jabber ◽  
Rasha Shakir Mahmood
Keyword(s):  
Nitric Oxide ◽  
Reactive Nitrogen Species ◽  
Tumor Formation ◽  
Cancer Development ◽  
Biological Processes ◽  
Nitrogen Species ◽  
Signal Molecule ◽  
Different Types ◽  
Proliferation And Metastasis

The Nitric oxide is a free radical belongs to reactive nitrogen species, acts as a signal molecule in many physiological and pathological processes as well as plays a significant role in a variety of biological processes including its action as a regulator to programmed cell death (apoptosis). In addition to its role in tumor formation, proliferation, and metastasis, Nitric oxide has also been stated to have tumoricidal effects. Therefore this review deals with the effect of nitric oxide on different types of cancer and its use in cancer drugs

scholarly journals m6A Modification: A Double-Edged Sword in Tumor Development

2021 ◽  
Vol 11 ◽  
Author(s):  
Runnan Gao ◽  
Mujie Ye ◽  
Baihui Liu ◽  
Meng Wei ◽  
Duan Ma ◽  
...  
Keyword(s):  
Dynamic Properties ◽  
Tumor Development ◽  
Tumor Formation ◽  
Cancer Development ◽  
Research Progress ◽  
Biological Processes ◽  
Rna Methylation ◽  
Anti Cancer ◽  
Elevated Expression

Modification of m6A, as the most abundant mRNA modification, plays diverse roles in various biological processes in eukaryotes. Emerging evidence has revealed that m6A modification is closely associated with the activation and inhibition of tumor pathways, and it is significantly linked to the prognosis of cancer patients. Aberrant reduction or elevated expression of m6A regulators and of m6A itself have been identified in numerous tumors. In this review, we give a description of the dynamic properties of m6A modification regulators, such as methyltransferases, demethylases, and m6A binding proteins, and indicate the value of the balance between these proteins in regulating the expression of diverse genes and the underlying effects on cancer development. Furthermore, we summarize the “dual-edged weapon” role of RNA methylation in tumor progression and discuss that RNA methylation can not only result in tumorigenesis but also lead to suppression of tumor formation. In addition, we summarize the latest research progress on small-molecule targeting of m6A regulators to inhibit or activate m6A. These studies indicate that restoring the balance of m6A modification via targeting specific imbalanced regulators may be a novel anti-cancer strategy.

scholarly journals Nitric Oxide, an Essential Intermediate in the Plant–Herbivore Interaction

2021 ◽  
Vol 11 ◽  
Author(s):  
Ana Arnaiz ◽  
Irene Rosa-Diaz ◽  
Maria C. Romero-Puertas ◽  
Luisa M. Sandalio ◽  
Isabel Diaz
Keyword(s):  
Nitric Oxide ◽  
Metabolic Pathway ◽  
Reactive Nitrogen Species ◽  
Plant Response ◽  
Nitrogen Species ◽  
Signal Molecule ◽  
Metabolic Intermediate ◽  
Plant Herbivore Interaction ◽  
Plant Herbivore ◽  
Herbivore Interaction

Reactive nitrogen species (RNS), mainly nitric oxide (NO), are highly reactive molecules with a prominent role in plant response to numerous stresses including herbivores, although the information is still very limited. This perspective article compiles the current progress in determining the NO function, as either a signal molecule, a metabolic intermediate, or a toxic oxidative product, as well as the contribution of molecules associated with NO metabolic pathway in the generation of plant defenses against phytophagous arthropods, in particular to insects and acari.

scholarly journals Nitric Oxide in Cerebral Vasospasm: Theories, Measurement, and Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Michael Siuta ◽  
Scott L. Zuckerman ◽  
J. Mocco
Keyword(s):  
Nitric Oxide ◽  
Cerebral Vasospasm ◽  
Reactive Nitrogen Species ◽  
Large Body ◽  
Treatment Strategies ◽  
Reactive Nitrogen ◽  
Future Research ◽  
Nitrogen Species ◽  
No Donors

In recent decades, a large body of research has focused on the role of nitric oxide (NO) in the development of cerebral vasospasm (CV) following subarachnoid hemorrhage (SAH). Literature searches were therefore conducted regarding the role of NO in cerebral vasospasm, specifically focusing on NO donors, reactive nitrogen species, and peroxynitrite in manifestation of vasospasm. Based off the assessment of available evidence, two competing theories are reviewed regarding the role of NO in vasospasm. One school of thought describes a deficiency in NO due to scavenging by hemoglobin in the cisternal space, leading to an NO signaling deficit and vasospastic collapse. A second hypothesis focuses on the dysfunction of nitric oxide synthase, an enzyme that synthesizes NO, and subsequent generation of reactive nitrogen species. Both theories have strong experimental evidence behind them and hold promise for translation into clinical practice. Furthermore, NO donors show definitive promise for preventing vasospasm at the angiographic and clinical level. However, NO augmentation may also cause systemic hypotension and worsen vasospasm due to oxidative distress. Recent evidence indicates that targeting NOS dysfunction, for example, through erythropoietin or statin administration, also shows promise at preventing vasospasm and neurotoxicity. Ultimately, the role of NO in neurovascular disease is complex. Neither of these theories is mutually exclusive, and both should be considered for future research directions and treatment strategies.

Plasmonic Enhancement of Nitric Oxide Generation

Nanoscale ◽  
2021 ◽  
Author(s):  
Rachael Knoblauch ◽  
Chris Geddes
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Reactive Nitrogen Species ◽  
Reactive Oxygen ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Plasmonic Enhancement ◽  
Cancer Treatments

While the utility of reactive oxygen species in photodynamic therapies for both cancer treatments and antimicrobial applications has received much attention, the inherent potential of reactive nitrogen species (RNS) including...

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