The role of nitric oxide and reactive nitrogen species in experimental ARDS

10.2741/s43 ◽  
2010 ◽  
Vol S2 (1) ◽  
pp. 18-29 ◽  
Author(s):  
Sebastian Rehberg
Keyword(s):  
Nitric Oxide ◽  
Reactive Nitrogen Species ◽  
Reactive Nitrogen ◽  
Nitrogen Species

scholarly journals Nitric Oxide in Cerebral Vasospasm: Theories, Measurement, and Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Michael Siuta ◽  
Scott L. Zuckerman ◽  
J. Mocco
Keyword(s):  
Nitric Oxide ◽  
Cerebral Vasospasm ◽  
Reactive Nitrogen Species ◽  
Large Body ◽  
Treatment Strategies ◽  
Reactive Nitrogen ◽  
Future Research ◽  
Nitrogen Species ◽  
No Donors

In recent decades, a large body of research has focused on the role of nitric oxide (NO) in the development of cerebral vasospasm (CV) following subarachnoid hemorrhage (SAH). Literature searches were therefore conducted regarding the role of NO in cerebral vasospasm, specifically focusing on NO donors, reactive nitrogen species, and peroxynitrite in manifestation of vasospasm. Based off the assessment of available evidence, two competing theories are reviewed regarding the role of NO in vasospasm. One school of thought describes a deficiency in NO due to scavenging by hemoglobin in the cisternal space, leading to an NO signaling deficit and vasospastic collapse. A second hypothesis focuses on the dysfunction of nitric oxide synthase, an enzyme that synthesizes NO, and subsequent generation of reactive nitrogen species. Both theories have strong experimental evidence behind them and hold promise for translation into clinical practice. Furthermore, NO donors show definitive promise for preventing vasospasm at the angiographic and clinical level. However, NO augmentation may also cause systemic hypotension and worsen vasospasm due to oxidative distress. Recent evidence indicates that targeting NOS dysfunction, for example, through erythropoietin or statin administration, also shows promise at preventing vasospasm and neurotoxicity. Ultimately, the role of NO in neurovascular disease is complex. Neither of these theories is mutually exclusive, and both should be considered for future research directions and treatment strategies.

Plasmonic Enhancement of Nitric Oxide Generation

Nanoscale ◽  
2021 ◽  
Author(s):  
Rachael Knoblauch ◽  
Chris Geddes
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Reactive Nitrogen Species ◽  
Reactive Oxygen ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Plasmonic Enhancement ◽  
Cancer Treatments

While the utility of reactive oxygen species in photodynamic therapies for both cancer treatments and antimicrobial applications has received much attention, the inherent potential of reactive nitrogen species (RNS) including...

scholarly journals Role of reactive nitrogen species in male infertility

2012 ◽  
Vol 10 (1) ◽  
pp. 109 ◽  
Author(s):  
Sejal B Doshi ◽  
Karishma Khullar ◽  
Rakesh K Sharma ◽  
Ashok Agarwal
Keyword(s):  
Male Infertility ◽  
Reactive Nitrogen Species ◽  
Reactive Nitrogen ◽  
Nitrogen Species

scholarly journals Functional complementation in yeast reveals a protective role of chloroplast 2-Cys peroxiredoxin against reactive nitrogen species

2003 ◽  
Vol 33 (5) ◽  
pp. 841-851 ◽  
Author(s):  
Atsushi Sakamoto ◽  
Shigefumi Tsukamoto ◽  
Hiroshi Yamamoto ◽  
Manami Ueda-Hashimoto ◽  
Misa Takahashi ◽  
...  
Keyword(s):  
Reactive Nitrogen Species ◽  
Protective Role ◽  
Functional Complementation ◽  
Reactive Nitrogen ◽  
Nitrogen Species
Sign in / Sign up

Export Citation Format

Share Document