scholarly journals THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRIT

2017 ◽  
Vol 24 (2) ◽  
Author(s):  
Andry Irawan ◽  
Ignatius Riwanto ◽  
Eriawan Agung Nugroho
Keyword(s):  
Green Tea ◽  
Benign Prostate Hyperplasia ◽  
Combination Group ◽  
Test Results ◽  
Prostate Hyperplasia ◽  
Significant Difference ◽  
The Mean ◽  
Randomized Control ◽  
The Difference ◽  
Benign Prostate

Objective: This study proves differentiation of the combination of dutasteride and green tea, dutasteride, green tea, and placebo alone and their association with differences in hematocrit levels and the expression of hypoxia induced factor-1 alpha (HIF-1α) in patients with Benign Prostate Hyperplasia (BPH) were performed Trans urethral resection of the prostate (TURP) surgery. Material & method: Experimental study with the draft "randomized control trial". Comparing angiogenesis changes between groups of BPH patients who underwent TURP surgery to assess the expression of HIF-1α and Δ Ht (Hematocrit) after administration of dutasteride, green tea with combination of dutasteride and green tea for 14 days. Results: The combination of dutasteride and green tea was not significant in reducing the expression of HIF-1α. Mean P1 group (59.32 ± 14.69); P2 group (59.11 ± 20.73); P3 group (64.21 ± 14.95); K group (58.16 ± 16.00). Kruskal test results obtained p=0.491 walis which means the difference percentage of HIF-1α among the 4 groups was not significant. The mean Δ Ht P1 group (0.61 ± 0.204); P2 group (0.54 ± 0.250); P3 group (0.41 ± 0.275); group K (0.41 ± 0.275). In statistical test with Mann Whitney test comparing the percentage reduction obtained Ht levels dutasteride group against group of green tea obtained p=0.213 means that there is no significant difference. Where a significant difference to the other groups. Conclusion: The combination of dutasteride and green tea for 14 days before TURP surgery does not reduce the expression of HIF-1α in BPH patients who underwent TURP surgery. Δ Ht significant decline in the combination group compared with other groups and might be influenced by several factors during TURP surgery.

scholarly journals Salbutamol nebulization for management of transient tachypnea of newborn (TTN).

2021 ◽  
Vol 28 (01) ◽  
pp. 52-59
Author(s):  
Fatima Maroof ◽  
Tehmina Maqbool ◽  
Hafiz Muhammad Irfan ◽  
Beenish Bashir Mughal ◽  
Ayesha ◽  
...  
Keyword(s):  
Placebo Group ◽  
Respiratory Rate ◽  
Test Results ◽  
Demographic Information ◽  
Significant Difference ◽  
Nebulized Salbutamol ◽  
The Mean ◽  
Randomized Control ◽  
The Difference ◽  
Trial Setting

Objective: To compare the mean change in respiratory rate with salbutamol nebulization versus placebo for treatment of transient tacyopnea of newborn. Study Design: Randomized Control Trial. Setting: Department of Neonatology, Federal Government Polyclinic (PGMI), Islamabad. Period: 8th August 2017 to 7th February 2018. Material & Methods: 100 neonates fulfilling selection criteria were enrolled in the study. Informed consent was obtained from parents. Demographic information was also noted. All baseline respiratory rate were noted. Neonates were divided into two groups by lottery method. Neonates in Treatment group were nebulized with Salbutamol. Placebo group was nebulized with Normal Saline. Then neonates were followed-up in N.I.C.U after 4 hours of second nebulization. After 4 hours, respiratory rates were assessed and change in respiratory rate was noted. Both groups were compared for mean reduction in respiratory rate by using independent sample t-test. Results: In nebulized salbutamol, group, mean respiratory rate was changed from 79.62±8.18bpm to 52.06±4.96bpm. This was a significant decrease (p<0.05). In placebo group, mean respiratory rate was changed from 81.88±8.86bpm to 62.50±6.75bpm. This was significant decrease (p<0.05). The difference between both groups at baseline was insignificant while after 4 hours was significant. The mean changed in respiratory rate with nebulized salbutamol was 27.56±6.83bpm while with placebo was 19.35±9.83bpm. There was significant difference in mean reduction in respiratory rate (p<0.05). Conclusion: It has been proved that nebulized salbutamol can be helpful in reducing respiratory rate significantly in neonates with TTN as compared to placebo.

scholarly journals Effect of Tiger Nut Meal on PSA, Relative Organ Weight Sperm Cell and Histological Changes in Androgen-induced Benign Prostate Hyperplasia in Adult Male Wistar Rats

2020 ◽  
pp. 1-10
Author(s):  
D. I. Izunwanne ◽  
J. N. Egwurugwu ◽  
C. L. Emegano
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Relative Weight ◽  
Organ Weight ◽  
Male Rats ◽  
Histological Changes ◽  
Prostate Hyperplasia ◽  
Morphological Studies ◽  
Significant Difference ◽  
Relative Organ Weight ◽  
Benign Prostate

Introduction: It is generally believed that Cyperus esculentus (tiger nut) has some fertility boosting effects. However, scientific validation of some the fertility boosting belief concerning tiger nut is lacking. Objective: The aim of this project was to study the effects of tiger nuts on PSA, Sperm midpiece, relative organ weight and histological changes in BPH induced rats. Method: A total of sixty (60) male rats weighing between 160 – 200 g were used in this study. They were divided into six groups of ten rats per group. Benign prostate hyperplasia was induced in three groups of the rats (as stated in methodology) with 30 mg/kg sub-cutaneous injections of hormones containing dihydrotestosterone (DHT) and estradiol valerate dissolved in olive oil in the ratio of 10:1 (three times in a week, one day interval). Administration of tiger nut meal commenced immediately and lasted for two months. At the end of administration, blood sample was collected from the rat via cardiac puncture for the determination of PSA. Semen sample was also collected for semen morphological studies. Internal organs notably, the prostate and the testes of the rats were also removed for histological examination. Results: The study showed that the induction of BPH brought about some adverse effects. On PSA, the administration of the tiger nut meal ameliorated the BPH by significantly reducing the increased level of the PSA which is a biomarker for prostate hyperplasia (P<0.05). The effect of the tiger nut on sperm morphological toxicities were also examined. Sperm abnormalities like those with bent midpiece was examined. The result showed that the administration of tiger nut meal significantly ameliorated the abnormality and thus, restored the morphology of the sperm cells such that it can enhance fertility. A significant difference was also seen in the relative weight of the prostate. The enlarged prostate in the induced + treated group was later observed through histological studies to have reduced significantly following the administration of the tiger nut. Conclusion: Tiger nut meal ameliorates BPH by reducing the PSA and enlarged prostate. It also ameliorates semen toxicities in the BPH induced + treated rats.

scholarly journals A comparative study of efficacy of tadalafil and alfuzosin regimens in patients of benign prostate hyperplasia

2018 ◽  
Vol 7 (6) ◽  
pp. 1123
Author(s):  
Supratik Das ◽  
Harjinder Singh ◽  
Vijay Kumar ◽  
Jasbir Singh
Keyword(s):  
Urine Analysis ◽  
Benign Prostate Hyperplasia ◽  
Digital Rectal Examination ◽  
Prostate Hyperplasia ◽  
Randomised Study ◽  
Non Invasive ◽  
Urinary Tract Symptoms ◽  
The Mean ◽  
Benign Prostate

Background: Aim of the study was to compare efficacy of Tadalafil and Alfuzosin regimens in patients of Benign Prostate Hyperplasia.Methods: It was a comparative, prospective, observational, non-invasive, parallel and randomised study conducted at the Outpatient Department of Urology, Rajindra Hospital, Patiala. 60 patients diagnosed with Benign Prostate Hyperplasia along with Lower Urinary Tract Symptoms, out which, 30 patients, consuming Tadalafil and 30 patients consuming Alfuzosin were considered. History regarding the concerned disease and the compliance of treatment was taken. Symptom scores were assessed with the help of International Prostate Symptom Score, Quality of Lifestyle Score and Erectile Dysfunction Score. Physical examination consisting of Focused Neurological Examination along with Digital Rectal Examination were conducted. Parameters like Renal Function Test, Urine analysis, Ultrasound of Prostate and uroflowmetry were also considered.Results: The mean age selected for study was 64 years for Tadalafil and Alfuzosin group. The mean level of IPS Score, Qol Score and ED Score at the first day of inclusion of patients were 23.96±4.49, 4±0.78, and 25.33±4.02 respectively for Tadalafil group and regarding Alfuzosin group they were 25.23±4.84, 3.56±0.81, and 26.1±4.04 respectively. Follow ups were conducted at 15 days, 1 month and 3 months for both the groups which were found to be statistically significant after 3 months and Alfuzosin showed a favourable result.Conclusions: Alfuzosin 10mg given at daily dose was found to have higher efficacy than Tadalafil (5mg).

scholarly journals Nocturia and benign prostatic hyperplasia

2008 ◽  
Vol 65 (10) ◽  
pp. 751-754
Author(s):  
Darko Laketic ◽  
Vesna Laketic
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Control Group ◽  
Favorable Result ◽  
Prostate Hyperplasia ◽  
Factors Associated ◽  
Significant Difference ◽  
Before And After ◽  
Bothersome Symptom ◽  
Group A ◽  
Benign Prostate

Background/Aim. Nocturia often occurs in patients with benign prostate hyperplasia (BPH). The aim of the study was to investigate the frequency of nocturia in patients with BPH. Nocturia and other factors associated with it were also investigated. Methods. Forty patients with the confirmed diagnosis of BPH were studied. Transurethral and transvesical prostatectomy were performed in all the patients. Symptoms were evaluated with the International Prostate Symptom Score before, as well as three and six months after the surgery. All the results were compared with the control group. Results. There was no statistically significant difference between the patients before and after the surgery regarding nocturia. There was, however, a statistically significant difference between the operated patients and the control group regarding nocturia, as well as a statistically significant correlation between noctruia and the age of the patients in both the investigated and the control group. A correlation also existed between nocturia and the prostatic size. Conclusion. There was no statistically significant improvement in symptoms of nocturia after the surgery. It is necessary to be very careful in decision making in patients with nonabsolute indiction for surgery and isolated bothersome symptom of nocturia. Age of a patient should also be considered in the evaluation of favorable result of the surgery because of a significant correlation between noctura and the age of a patient.

scholarly journals Association between Hyperglycemia and Prostate Volume in Patients with Benign Prostate Enlargement : A Hospital Case-Control Study

2017 ◽  
Vol 3 (2) ◽  
pp. 46
Author(s):  
Eriawan Agung Nugroho ◽  
Rickky Kurniawan
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Prostate Volume ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Prostate Hyperplasia ◽  
Increased Risk ◽  
Prostate Enlargement ◽  
Significant Difference ◽  
Spearman Test ◽  
Benign Prostate

Introduction: Prostate is a male organ which might enlarge mostly, either benign or malignant. Hyperglycemia is one of the factor that increase the risk of  benign prostate hyperplasia. There is lack of studies which assessed the relationship between benign prostate hyperplasia and isolated hyperglycemia. The aim of this study was to evaluate the association between hyperglycemia and prostate volume in patients with benign prostate enlargement in dr. Kariadi Hospital Semarang.  Method: We conducted a retrospective analysis of clinical data which obtained from 640 men between 2010 and 2012 who admitted to the hospital with diagnosis of benign prostate enlargement. By their medical records, these patients were evaluated of their plasma glucose level and prostate volume by trans rectal ultrasound. The  presence  of  hyperglycemia  was  determined  based  on  the  American  Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Patients have already been diagnosed with controlled diabetes mellitus by an internist. We allocated the subjects into two groups: patients with hyperglycemia and non-hyperglycemia. Logistic regression analysis was used to assess whether hyperglycemia was associated with the increased risk of benign prostate enlargement.Results: Significant difference of prostate volume found between groups. Prostate volume was  significantly greater in hyperglycemia group compared with non-hyperglycemia ones in all sub-groups based on age (in decades). Odds Ratio (OR) in patients with hyperglycemia was 2.25 (95% CI: 1.23-4.11). By non-parametric Spearman test it obtained  Group 1 (P1) p = 0.000 and r = 0.669, group 2 (P2) it obtained p = 0.000 and r = 0.672, group 3 (P3) it obtained p = 0.000 and r = 0.415 which implied strong positive associationConclusion: Hyperglycemia and prostate volume were significantly associated in patients with benign prostate enlargement. Hyperglycemia became a significant risk factor  for  prostate  enlargement  in  patients  with  benign  prostate  enlargement  in dr. Kariadi Hospital Semarang.

scholarly journals Comparing Functional Movement Screen Scores Between Athlete and Non-Athlete Female Students

2020 ◽  
Vol 5 (4) ◽  
pp. 240-249
Author(s):  
Maral Entezami ◽  
◽  
Ali Shamsi Majelan ◽  
Hasan Daneshmandi ◽  
◽  
...  
Keyword(s):  
Female Athletes ◽  
Movement Patterns ◽  
Female Students ◽  
Functional Movement Screen ◽  
Test Results ◽  
Functional Movement ◽  
Significance Level ◽  
Significant Difference ◽  
The Mean ◽  
The Difference

Objective: The present study aimed to compare the Functional Movement Screen (FMS) scores between athlete and non-athlete female students. Methods: Participants were 30 athlete female students (Mean±SD age, 23.36±3.10 years; Mean±SD height, 163.45±5.06 cm; Mean±SD weight, 57.40±6.43 kg) and 30 non-athlete female students (Mean±SD age, 25.00±2.36 years; Mean±SD height, 162.6±3.72; Mean±SD weight, 58.76±9.29 kg). They underwent FMS to assess their movement patterns. Mann–Whitney U test was used to compare the mean FMS scores between athletes and non-athletes. Data analysis was performed in SPSS v. 22 software at a significance level of P≥0.05. Results: The Mann–Whitney U test results showed a significant difference between the total mean FMS scores of female athletes and non-athletes (P=0.001). Considering a cut-off point of 14, Results revealed that 66% of athletes 40% of non-athletes had a FMS score <14, while 93.34% of athletes and 60% of non-athletes had a FMS score >14. Conclusion: FMS can help identify the difference in movement patterns between female athletes and non-athletes. Higher FMS scores of female athletes indicate that non-athletes have poor movement patterns which suggest that they are more likely to be injured if they engage in sports activities.

scholarly journals DOXAZOSIN AND MELOXICAM COMBINATION THERAPY FOR BPH TREATMENT WITH LUTS

2014 ◽  
Vol 21 (1) ◽  
Author(s):  
Wayan Suarsana ◽  
Sunaryo Hardjowijoto ◽  
Soetojo Wirjopranoto ◽  
Budiono Budiono
Keyword(s):  
Blood Flow ◽  
Combination Therapy ◽  
Benign Prostate Hyperplasia ◽  
Double Blind Study ◽  
Urinary Flow ◽  
Prostate Hyperplasia ◽  
Once Daily ◽  
Significant Difference ◽  
Grade Ii ◽  
Benign Prostate

Objective: To compare the efficacy of combination therapy of 4 mg doxazosin + 15 mg meloxicam with 4 mg doxazosin single therapy for benign prostate hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS). Materials & Methods: A prospective, randomized and double blind study with total of 22 BPH patients with LUTS were randomized to receive 4 mg doxazosin + placebo once daily for 6 weeks or a combination of 4 mg doxazosin + 15 mg meloxicam once daily for 6 weeks. Inclusion criteria included IPSS ≥ 8, age > 50 years, prostate blood flow grade II. Therapeutic efficacy was assessed by comparing changes in IPSS, maximal urinary flow (Q-max) and changes in prostate blood flow between baseline and immediately after 6 weeks of therapy. Results: There was no significant difference in IPSS change between the two treatment groups (delta IPSS 4 ± 1.1 versus 3.7 ± 1.5, p = 0.630). There was a significant difference in Q-max changes between the two groups (delta Q-max 4 ± 1.5 versus 2.1 ± 0.7, p < 0.001). In group therapied with 4 mg doxazosin + 15 mg meloxicam prostate blood flow decreased from grade II to grade I in 9 of 11 patients (81%). Whereas, in the treatment group of 4 mg doxazosin + placebo no reduction was found in prostate blood flow. Conclusion: Combination therapy of 4 mg doxazosin + 15 mg meloxicam once daily for 6 weeks is better than 4 mg doxazosin therapy alone in improving Q-max and decreasing prostate blood flow in BPH patients with LUTS.Keywords: Benign prostate hyperplasia, inflammation, COX-2 inhibitors.

scholarly journals Efficacy of Combination Dutasteride and Lycopene to Reduce Bleeding in Benign Prostate Hyperplasia (BPH) Post- Transurethral Resection of the Prostate (TURP) Overview of Hypoxia inducible factor-1 alpha (HIF-1 α) Expression and Hematocrit Levels

2020 ◽  
Vol 25 (1) ◽  
pp. 1
Author(s):  
Eriawan Agung Nugroho ◽  
Siti Amarwati ◽  
Nugroho Akhbar
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Controlled Trial ◽  
Hypoxia Inducible Factor ◽  
T Test ◽  
Double Blind ◽  
Prostate Hyperplasia ◽  
Post Surgery ◽  
Post Test ◽  
The Difference ◽  
Benign Prostate

Trans Urethral Resection of the Prostate (TURP) is one of the gold operating standards for people with Benign Prostate Hyperplasia (BPH), but the complications, like bleedings, often occur both in durante and post-surgery. The risk of bleeding in TURP is caused by angiogenesis. Hypoxia-Induced Factor-1 Alpha (HIF-1 α) is one of the trigger factors for angiogenesis in BPH. Based on the existing literature, it was found that there was a relationship between lycopene and dutasteride which both had a synergistic effect in inhibiting angiogenesis. However, the mechanism is unknown. This study aims to assess the effectiveness of the combination of dutasteride and lycopene on the expression of HIF-1α and hematocrit levels in BPH patients undergoing TURP surgery. This research was an experimental study with "Double-Blind Randomized Controlled Trial Post Test Only Design". The 22 patients were divided into 2 groups, namely T (dutasteride + lycopene), C (lycopene+plasebo), which were given every 24 hours for a minimum of 30 days until the TURP operation was carried out. The observation of HIF-1α expression used immunohistochemical methods. Different tests were conducted between the groups with Independent T-test. The result shows the combination of dutasteride and lycopene was not significant in reducing the HIF-1α expression, indicated by mean rank in the group (C) (= 21.60), group (T) (= 20.00). The results obtained from the Independent   T-test were (p = 0.410), meaning the difference in HIF-1α expression between the 2 groups was not significant: Average Δ Ht group C (= 1.26); group T (= -0,98). The statistical test with the Independent T-test obtained (p = 0.027), where there were significant differences. Giving a combination of dutasteride and lycopene for at least 30 days pre-TURP surgery was not effective in reducing the expression of hypoxia-induced factor - 1 alpha (HIF-1α) but was effective in reducing hematocrit levels compared to a single administration of dutasteride in BPH patients undergoing TURP surgery.

HUBUNGAN USIA, OBESITAS DAN RIWAYAT PENYAKIT DIABETES MELLITUS DENGAN KEJADIAN BENIGN PROSTATE HYPERPLASIA (BPH) DERAJAT IV DI RSUD DR. M. HAULUSSY AMBON PERIODE 2012-2014

2017 ◽  
pp. 141-151
Author(s):  
Andrew Ruspanah
Keyword(s):  
Diabetes Mellitus ◽  
Benign Prostate Hyperplasia ◽  
Chi Square ◽  
Cross Sectional ◽  
Prostate Hyperplasia ◽  
Benign Prostate

Pendahuluan. Benign Postate Hiperplasia (BPH) adalah penyakit yang umumnya terjadi pada pria lansia yang disebabkan oleh penuaan. Hiperplasia prostat adalah pertumbuhan jaringan nodul fibroadenomatosa pada prostat. Pembesaran prostat jinak merupakan penyakit yang tersering kedua setelah batu saluran kemih didapatkan secara klinis di Indonesia. Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan antara usia, obesitas dan riwayat diabetes mellitus dengan kejadian Benign Prostate Hyperplasia (BPH) grade IV di Rumah Sakit Dr. M. Haulussy Ambon periode 2012-2014. Metode. Jenis penelitian ini adalah penelitian analitik desain Cross-Sectional, dengan menggunakan catatan medis data di ruang operasi di Rumah Sakit Dr. M. Haulussy Ambon Tahun 2012-2014 dan memperoleh jumlah sampel yang memenuhi kriteria inklusi sebanyak 239, yang diambil dengan teknik total sampling. Analisis dilakukan dengan analisis univariat dan bivariat menggunakan uji Chi Square. Hasil yang di temukan dalam penelitian ini bahwa kejadian BPH lebih besar pada mereka yang berusia> 65 tahun dan 56-65 tahun dibandingkan dengan usia 46-55 dan <46 tahun dengan hasil tes menunjukkan adanya hubungan antara usia dengan BPH dengan nilai (p= 0,000), ada hubungan antara obesitas dengan nilai BPH (p=0,019) dan riwayat diabetes mellitus setelah menggunakan uji Chi-Square, hubungan antara riwayat diabetes mellitus dengan BPH dengan nilai (p = 0,000). Kesimpulan. Ada hubungan antara umur, obesitas dan riwayat diabetes mellitus dengan kejadian BPH.

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