scholarly journals DOXAZOSIN AND MELOXICAM COMBINATION THERAPY FOR BPH TREATMENT WITH LUTS

2014 ◽  
Vol 21 (1) ◽  
Author(s):  
Wayan Suarsana ◽  
Sunaryo Hardjowijoto ◽  
Soetojo Wirjopranoto ◽  
Budiono Budiono
Keyword(s):  
Blood Flow ◽  
Combination Therapy ◽  
Benign Prostate Hyperplasia ◽  
Double Blind Study ◽  
Urinary Flow ◽  
Prostate Hyperplasia ◽  
Once Daily ◽  
Significant Difference ◽  
Grade Ii ◽  
Benign Prostate

Objective: To compare the efficacy of combination therapy of 4 mg doxazosin + 15 mg meloxicam with 4 mg doxazosin single therapy for benign prostate hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS). Materials & Methods: A prospective, randomized and double blind study with total of 22 BPH patients with LUTS were randomized to receive 4 mg doxazosin + placebo once daily for 6 weeks or a combination of 4 mg doxazosin + 15 mg meloxicam once daily for 6 weeks. Inclusion criteria included IPSS ≥ 8, age > 50 years, prostate blood flow grade II. Therapeutic efficacy was assessed by comparing changes in IPSS, maximal urinary flow (Q-max) and changes in prostate blood flow between baseline and immediately after 6 weeks of therapy. Results: There was no significant difference in IPSS change between the two treatment groups (delta IPSS 4 ± 1.1 versus 3.7 ± 1.5, p = 0.630). There was a significant difference in Q-max changes between the two groups (delta Q-max 4 ± 1.5 versus 2.1 ± 0.7, p < 0.001). In group therapied with 4 mg doxazosin + 15 mg meloxicam prostate blood flow decreased from grade II to grade I in 9 of 11 patients (81%). Whereas, in the treatment group of 4 mg doxazosin + placebo no reduction was found in prostate blood flow. Conclusion: Combination therapy of 4 mg doxazosin + 15 mg meloxicam once daily for 6 weeks is better than 4 mg doxazosin therapy alone in improving Q-max and decreasing prostate blood flow in BPH patients with LUTS.Keywords: Benign prostate hyperplasia, inflammation, COX-2 inhibitors.

scholarly journals Effect of Tiger Nut Meal on PSA, Relative Organ Weight Sperm Cell and Histological Changes in Androgen-induced Benign Prostate Hyperplasia in Adult Male Wistar Rats

2020 ◽  
pp. 1-10
Author(s):  
D. I. Izunwanne ◽  
J. N. Egwurugwu ◽  
C. L. Emegano
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Relative Weight ◽  
Organ Weight ◽  
Male Rats ◽  
Histological Changes ◽  
Prostate Hyperplasia ◽  
Morphological Studies ◽  
Significant Difference ◽  
Relative Organ Weight ◽  
Benign Prostate

Introduction: It is generally believed that Cyperus esculentus (tiger nut) has some fertility boosting effects. However, scientific validation of some the fertility boosting belief concerning tiger nut is lacking. Objective: The aim of this project was to study the effects of tiger nuts on PSA, Sperm midpiece, relative organ weight and histological changes in BPH induced rats. Method: A total of sixty (60) male rats weighing between 160 – 200 g were used in this study. They were divided into six groups of ten rats per group. Benign prostate hyperplasia was induced in three groups of the rats (as stated in methodology) with 30 mg/kg sub-cutaneous injections of hormones containing dihydrotestosterone (DHT) and estradiol valerate dissolved in olive oil in the ratio of 10:1 (three times in a week, one day interval). Administration of tiger nut meal commenced immediately and lasted for two months. At the end of administration, blood sample was collected from the rat via cardiac puncture for the determination of PSA. Semen sample was also collected for semen morphological studies. Internal organs notably, the prostate and the testes of the rats were also removed for histological examination. Results: The study showed that the induction of BPH brought about some adverse effects. On PSA, the administration of the tiger nut meal ameliorated the BPH by significantly reducing the increased level of the PSA which is a biomarker for prostate hyperplasia (P<0.05). The effect of the tiger nut on sperm morphological toxicities were also examined. Sperm abnormalities like those with bent midpiece was examined. The result showed that the administration of tiger nut meal significantly ameliorated the abnormality and thus, restored the morphology of the sperm cells such that it can enhance fertility. A significant difference was also seen in the relative weight of the prostate. The enlarged prostate in the induced + treated group was later observed through histological studies to have reduced significantly following the administration of the tiger nut. Conclusion: Tiger nut meal ameliorates BPH by reducing the PSA and enlarged prostate. It also ameliorates semen toxicities in the BPH induced + treated rats.

scholarly journals Nocturia and benign prostatic hyperplasia

2008 ◽  
Vol 65 (10) ◽  
pp. 751-754
Author(s):  
Darko Laketic ◽  
Vesna Laketic
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Control Group ◽  
Favorable Result ◽  
Prostate Hyperplasia ◽  
Factors Associated ◽  
Significant Difference ◽  
Before And After ◽  
Bothersome Symptom ◽  
Group A ◽  
Benign Prostate

Background/Aim. Nocturia often occurs in patients with benign prostate hyperplasia (BPH). The aim of the study was to investigate the frequency of nocturia in patients with BPH. Nocturia and other factors associated with it were also investigated. Methods. Forty patients with the confirmed diagnosis of BPH were studied. Transurethral and transvesical prostatectomy were performed in all the patients. Symptoms were evaluated with the International Prostate Symptom Score before, as well as three and six months after the surgery. All the results were compared with the control group. Results. There was no statistically significant difference between the patients before and after the surgery regarding nocturia. There was, however, a statistically significant difference between the operated patients and the control group regarding nocturia, as well as a statistically significant correlation between noctruia and the age of the patients in both the investigated and the control group. A correlation also existed between nocturia and the prostatic size. Conclusion. There was no statistically significant improvement in symptoms of nocturia after the surgery. It is necessary to be very careful in decision making in patients with nonabsolute indiction for surgery and isolated bothersome symptom of nocturia. Age of a patient should also be considered in the evaluation of favorable result of the surgery because of a significant correlation between noctura and the age of a patient.

Holmium laser enucleation of prostate for patients with acute urinary retention due to benign prostate hyperplasia: Efficacy and safety

2019 ◽  
Author(s):  
Pu Li(Former Corresponding Author) ◽  
Jun Tao ◽  
Chengming Wang ◽  
Min Tang ◽  
Xiaoxin Meng(New Corresponding Author)
Keyword(s):  
Urinary Retention ◽  
Acute Urinary Retention ◽  
Benign Prostate Hyperplasia ◽  
Holmium Laser ◽  
Common Disease ◽  
Urinary Flow ◽  
Prostate Hyperplasia ◽  
Laser Enucleation ◽  
Benign Prostate ◽  
Holmium Laser Enucleation

Abstract Background Benign prostate hyperplasia (BPH) is a common disease in older men, and part of patients develop acute urinary retention (AUR) at the time of initial treatment. The aim of this study was to evaluate the effectiveness and safety of holmium laser enucleation of prostate (HoLEP) for patients with BPH in setting of AUR. Methods The clinical data of 88 patients with BPH who underwent HoLEP surgery in our center were retrospectively analyzed. AUR existed in 34 patients and the other 54 patients had no AUR. The general information, prostate volume, urodynamic parameters and intraoperative parameters were recoeded and compared. The outcome were recorded and analysed including the international prostate symptom score (IPSS), quality of life score (QoL), maximum urinary flow rate (Qmax), and post-voiding residual (PVR). Results In both groups, the preoperative parameters were equivalent except for the white blood cell in urinalysis. All the HoLEP procedures were smoothly carried out. The intr- and post-operative complications were low in both groups and no difference were detected. All the patients were followed up for at least 6 months. IPSS, QoL, Qmax and PVR were all improved in both groups. No statistical differences were obtained in these parameters between groups. Conclusion s HoLEP could be a safe and effective treatment for BPH patients either with or without AUR. The efficacy was immediate and sustained during the short-term follow-up session in both groups.

scholarly journals Research on Applications of Transurethral Plasmakinetic Enucleation of the Prostate in Elderly Patients Aged ≥80 Years

2021 ◽  
Vol 8 ◽  
Author(s):  
Wen Su ◽  
Ye Yi ◽  
Liang Zeng ◽  
Jin Tang
Keyword(s):  
Elderly Patients ◽  
Transurethral Resection ◽  
Benign Prostate Hyperplasia ◽  
Specific Antigen ◽  
Urinary Flow ◽  
Prostate Hyperplasia ◽  
Flushing Time ◽  
Benign Prostate

Objective: To evaluate the safety and efficacy of transurethral plasmakinetic enucleation of the prostate (PKERP) vs. transurethral resection of the prostate (TURP) in elderly patients aged ≥80 years with benign prostate hyperplasia.Materials and Methods: We conducted a retrospective analysis of the PKERP (n = 123) and TURP (n = 143) in patients aged ≥80 years at urology department of The Third Xiangya Hospital of Central South University from January 2016 to October 2019. Then the preoperative, intraoperative, and postoperative data of different indicators were compared between the two groups. The follow-up was done at 3 months, 1 year after surgical treatment.Results: No significant differences were observed between the two groups for the baseline characteristics, including age, prostate volume, prostate-specific antigen (PSA) level, concurrent disease, maximum urinary flow rate (MFR), international prostate symptoms score (IPSS), and quality of life (QoL) score. The operative time, hemoglobin decrease, and postoperative flushing time were significantly lower in the PKERP group compared with the TURP group. However, no significant differences were observed between both groups for postoperative hospital stay, incidence of transurethral resection syndrome (TURS), prostatic capsular perforation, and genuine urinary incontinence. The follow-up results showed that the MFR of the PKERP group was significantly higher than the TURP group at 1 year after surgery.Conclusion: Compared with TURP, PKERP is a safe and efficacious method for treating patients aged ≥80 years with benign prostate hyperplasia, and it may improve long-term urination symptoms.

scholarly journals Comparison of Penile Cuff Test and Conventional Urodynamic Study Prior to Photoselective Vaporization of Prostate for Benign Prostate Hyperplasia Using a 120 W GreenLight High Performance System Laser

2020 ◽  
Vol 9 (4) ◽  
pp. 1189
Author(s):  
Kang Sup Kim ◽  
Yong Sun Choi ◽  
Woong Jin Bae ◽  
Hyuk Jin Cho ◽  
Ji Youl Lee ◽  
...  
Keyword(s):  
Bladder Outlet Obstruction ◽  
Benign Prostate Hyperplasia ◽  
Outlet Obstruction ◽  
Urinary Flow ◽  
Urodynamic Study ◽  
Prostate Hyperplasia ◽  
Predictive Values ◽  
Number Of Patients ◽  
Photoselective Vaporization ◽  
Benign Prostate

Background: We compared the utility of the penile cuff test (PCT) and the conventional urodynamic study (UDS) for the preoperative assessment of patients undergoing scheduled photoselective vaporization of the prostate (PVP) for benign prostate hyperplasia (BPH). Methods: Fifty-nine patients with voiding lower urinary tract symptoms (LUTS) underwent a simultaneous PCT and conventional UDS before PVP. The modified International Continence Society (ICS) nomogram was used to confirm bladder outlet obstruction after measuring maximum urinary flow rate and highest pressure at flow interruption. The PCT and UDS results, in terms of modified ICS nomogram predictions, were compared. Their sensitivities, specificities, and positive and negative predictive values were calculated. Results: Thirty-six patients were diagnosed as obstructed and 23 as non-obstructed/equivocal using the modified ICS nomogram during the PCT. All 36 of the first group were confirmed as obstructed by UDS. Of the 23 diagnosed as non-obstructed/equivocal by the PCT, 14 were confirmed to be non-obstructed by UDS, with nine diagnosed as obstructed. The PCT showed a sensitivity of 80% and a specificity of 100%. The positive and negative predictive values were 100% and 60.9%, respectively. Conclusions: In conclusion, despite our small number of patients, the PCT’s high sensitivity and specificity suggest that it may provide diagnostic information about bladder outlet obstruction before PVP for patients with voiding LUTS. Evidently, the PCT has the potential to be used for some patients as a screening alternative to invasive UDS.

scholarly journals Association between Hyperglycemia and Prostate Volume in Patients with Benign Prostate Enlargement : A Hospital Case-Control Study

2017 ◽  
Vol 3 (2) ◽  
pp. 46
Author(s):  
Eriawan Agung Nugroho ◽  
Rickky Kurniawan
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Prostate Volume ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Prostate Hyperplasia ◽  
Increased Risk ◽  
Prostate Enlargement ◽  
Significant Difference ◽  
Spearman Test ◽  
Benign Prostate

Introduction: Prostate is a male organ which might enlarge mostly, either benign or malignant. Hyperglycemia is one of the factor that increase the risk of  benign prostate hyperplasia. There is lack of studies which assessed the relationship between benign prostate hyperplasia and isolated hyperglycemia. The aim of this study was to evaluate the association between hyperglycemia and prostate volume in patients with benign prostate enlargement in dr. Kariadi Hospital Semarang.  Method: We conducted a retrospective analysis of clinical data which obtained from 640 men between 2010 and 2012 who admitted to the hospital with diagnosis of benign prostate enlargement. By their medical records, these patients were evaluated of their plasma glucose level and prostate volume by trans rectal ultrasound. The  presence  of  hyperglycemia  was  determined  based  on  the  American  Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Patients have already been diagnosed with controlled diabetes mellitus by an internist. We allocated the subjects into two groups: patients with hyperglycemia and non-hyperglycemia. Logistic regression analysis was used to assess whether hyperglycemia was associated with the increased risk of benign prostate enlargement.Results: Significant difference of prostate volume found between groups. Prostate volume was  significantly greater in hyperglycemia group compared with non-hyperglycemia ones in all sub-groups based on age (in decades). Odds Ratio (OR) in patients with hyperglycemia was 2.25 (95% CI: 1.23-4.11). By non-parametric Spearman test it obtained  Group 1 (P1) p = 0.000 and r = 0.669, group 2 (P2) it obtained p = 0.000 and r = 0.672, group 3 (P3) it obtained p = 0.000 and r = 0.415 which implied strong positive associationConclusion: Hyperglycemia and prostate volume were significantly associated in patients with benign prostate enlargement. Hyperglycemia became a significant risk factor  for  prostate  enlargement  in  patients  with  benign  prostate  enlargement  in dr. Kariadi Hospital Semarang.

scholarly journals THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRIT

2017 ◽  
Vol 24 (2) ◽  
Author(s):  
Andry Irawan ◽  
Ignatius Riwanto ◽  
Eriawan Agung Nugroho
Keyword(s):  
Green Tea ◽  
Benign Prostate Hyperplasia ◽  
Combination Group ◽  
Test Results ◽  
Prostate Hyperplasia ◽  
Significant Difference ◽  
The Mean ◽  
Randomized Control ◽  
The Difference ◽  
Benign Prostate

Objective: This study proves differentiation of the combination of dutasteride and green tea, dutasteride, green tea, and placebo alone and their association with differences in hematocrit levels and the expression of hypoxia induced factor-1 alpha (HIF-1α) in patients with Benign Prostate Hyperplasia (BPH) were performed Trans urethral resection of the prostate (TURP) surgery. Material & method: Experimental study with the draft "randomized control trial". Comparing angiogenesis changes between groups of BPH patients who underwent TURP surgery to assess the expression of HIF-1α and Δ Ht (Hematocrit) after administration of dutasteride, green tea with combination of dutasteride and green tea for 14 days. Results: The combination of dutasteride and green tea was not significant in reducing the expression of HIF-1α. Mean P1 group (59.32 ± 14.69); P2 group (59.11 ± 20.73); P3 group (64.21 ± 14.95); K group (58.16 ± 16.00). Kruskal test results obtained p=0.491 walis which means the difference percentage of HIF-1α among the 4 groups was not significant. The mean Δ Ht P1 group (0.61 ± 0.204); P2 group (0.54 ± 0.250); P3 group (0.41 ± 0.275); group K (0.41 ± 0.275). In statistical test with Mann Whitney test comparing the percentage reduction obtained Ht levels dutasteride group against group of green tea obtained p=0.213 means that there is no significant difference. Where a significant difference to the other groups. Conclusion: The combination of dutasteride and green tea for 14 days before TURP surgery does not reduce the expression of HIF-1α in BPH patients who underwent TURP surgery. Δ Ht significant decline in the combination group compared with other groups and might be influenced by several factors during TURP surgery.

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