Formation of Bistrand Abasic Site

2020 ◽  
Author(s):  
Keyword(s):  
Abasic Site

Mutagenic properties of a unique abasic site in mammalian cells

1990 ◽  
Vol 173 (2) ◽  
pp. 704-710 ◽  
Author(s):  
A. Gentil ◽  
G. Renault ◽  
C. Madzak ◽  
A. Margot ◽  
J.B. Cabral-Neto ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Abasic Site

scholarly journals DNA oligonucleotides with A, T, G or C opposite an abasic site: structure and dynamics

2007 ◽  
Vol 36 (1) ◽  
pp. 253-262 ◽  
Author(s):  
Jingyang Chen ◽  
François-Yves Dupradeau ◽  
David A. Case ◽  
Christopher J. Turner ◽  
JoAnne Stubbe
Keyword(s):  
Abasic Site ◽  
Site Structure ◽  
Structure And Dynamics ◽  
Dna Oligonucleotides

Solution Structure of a Duplex DNA with an Abasic Site in a dA Tract†

Biochemistry ◽  
1997 ◽  
Vol 36 (39) ◽  
pp. 11629-11639 ◽  
Author(s):  
Ke Yu Wang ◽  
Sharon A. Parker ◽  
Igor Goljer ◽  
Philip H. Bolton
Keyword(s):  
Solution Structure ◽  
Duplex Dna ◽  
Abasic Site

Search for DNA Repair Inhibitors:  Selective Binding of Nucleic Bases−Acridine Conjugates to a DNA Duplex Containing an Abasic Site†

1997 ◽  
Vol 40 (21) ◽  
pp. 3346-3352 ◽  
Author(s):  
Nathalie Berthet ◽  
Jean-François Constant ◽  
Martine Demeunynck ◽  
Pierre Michon ◽  
Jean Lhomme
Keyword(s):  
Dna Repair ◽  
Abasic Site ◽  
Dna Duplex ◽  
Selective Binding ◽  
Nucleic Bases ◽  
Dna Repair Inhibitors

scholarly journals NMR Solution Structures of Bistranded Abasic Site Lesions in DNA†‡

Biochemistry ◽  
2008 ◽  
Vol 47 (46) ◽  
pp. 11909-11919 ◽  
Author(s):  
Raphael D. Hazel ◽  
Kegui Tian ◽  
Carlos de los Santos
Keyword(s):  
Abasic Site ◽  
Solution Structures ◽  
Nmr Solution Structures

scholarly journals Biotinylation of Deoxyguanosine at the Abasic Site in Double-Stranded Oligodeoxynucleotides

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Chun Wu
Keyword(s):  
Dna Polymerase ◽  
Click Reaction ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Sequencing Analysis ◽  
Abasic Site ◽  
Nylon Membrane ◽  
Abasic Sites ◽  
Polymerase Chain ◽  
Dna Sequencing Analysis ◽  
Endonuclease Digestion

Biotinylation of deoxyguanosine at an abasic site in double-stranded oligodeoxynucleotides was studied. The biotinylation of deoxyguanosine is achieved by copper-catalyzed click reaction after the conjugation of the oligodeoxynucleotide with 2-oxohex-5-ynal. The biotinylation enables visualization of the biotinylated oligodeoxynucleotides by chemiluminescence on a nylon membrane. In order to investigate the biotinylated site, the biotinylated oligodeoxynucleotides were amplified by the DNA polymerase chain reaction. Replacement of guanine opposing the abasic site with adenine generated by the activity of the terminal deoxynucleotidyl transferase of DNA polymerase was detected by DNA sequencing analysis and restriction endonuclease digestion. This study suggests that 2-oxohex-5-ynal may be useful for the detection of the unpaired deoxyguanosine endogenously generated at abasic sites in genomic DNA.

Competitive Assay for Theophylline Based on an Abasic Site-Containing DNA Duplex Aptamer and a Fluorescent Ligand

2012 ◽  
Vol 18 (40) ◽  
pp. 12719-12724 ◽  
Author(s):  
Yusuke Sato ◽  
Yushuang Zhang ◽  
Seiichi Nishizawa ◽  
Takehiro Seino ◽  
Kodai Nakamura ◽  
...  
Keyword(s):  
Abasic Site ◽  
Dna Duplex ◽  
Competitive Assay ◽  
Fluorescent Ligand
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