scholarly journals Villous Projections of the Neoplastic Epithelium Present

2020 ◽  
Author(s):  
Keyword(s):  
Neoplastic Epithelium

MIP3 alpha stimulates the migration of Langerhans cells in models of human papillomavirus (HPV)-associated (pre)neoplastic epithelium

2006 ◽  
Vol 56 (7) ◽  
pp. 1087-1096 ◽  
Author(s):  
Ludivine Herman ◽  
Pascale Hubert ◽  
Jean-Hubert Caberg ◽  
Brigitte Evrard ◽  
Witold Kedzia ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Langerhans Cells ◽  
Neoplastic Epithelium

Patterns of cytokeratin expression by neoplastic and non-neoplastic epithelium

1993 ◽  
Vol 162 (3) ◽  
pp. 77-81 ◽  
Author(s):  
G. Mortimer ◽  
D. N. Jones ◽  
H. Assaf ◽  
T. Al-Ahmadi
Keyword(s):  
Cytokeratin Expression ◽  
Neoplastic Epithelium

scholarly journals Mixed Apocrine Sweat Gland Tumor of the Tail in a Cow

2002 ◽  
Vol 39 (2) ◽  
pp. 281-285 ◽  
Author(s):  
M. Y. Gulbahar ◽  
I. Alkan ◽  
L. Aslan ◽  
I. Golen
Keyword(s):  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Neuron Specific Enolase ◽  
Giant Cells ◽  
Osteogenic Potential ◽  
Cytokeratin 19 ◽  
Alpha Smooth Muscle Actin ◽  
Tumor Mass ◽  
Native Breed ◽  
Neoplastic Epithelium

A 4-year-old native-breed cow had a mass with wide areas of ulceration and hemorrhage at the base of the tail at the same level as the vulva. The tumor was 19 X 13 X 11 cm, appeared red-brown, and was firm to hard, with gritty areas apparent on cut surface. Histologically, the tumor mass was composed of multilayered epithelial cells forming glandular structures with occasional apical blebs and rare solidly packed cells in nests. The stroma included fibrous connective tissue, scattered or periglandular sheets of spindle-shaped cells resembling myoepithelium, several cartilaginous formations, and numerous irregular islands of mineralized osteoid, well-formed bone trabeculae lined by osteoblasts, and many osteoclast-like multinucleated giant cells among or near the neoplastic epithelium. Immunohistochemically, the neoplastic epithelium was positive for pan-cytokeratin (AE1/AE2) and cytokeratin 19 but was negative for cytokeratin 18. Spindle-shaped cells were stained with alpha smooth muscle actin (αSMA) and to a lesser extent vimentin antibodies. The cells of osteogenic lineage and spindle cells closely associated with the osteoid showed strong immunostaining for vimentin but not for αSMA. Immunostaining for neuron-specific enolase and S100 protein was not observed in any component of the tumor mass. These findings suggested that the origin of bone formation was undifferentiated mesenchymal cells with osteogenic potential.

Human cytomegalovirus preferentially infects the neoplastic epithelium of colorectal cancer: A quantitative and histological analysis

2012 ◽  
Vol 54 (3) ◽  
pp. 240-244 ◽  
Author(s):  
Hsin-Pai Chen ◽  
Jeng-Kai Jiang ◽  
Cheng-Yu Chen ◽  
Teh-Ying Chou ◽  
Yen-Chung Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Human Cytomegalovirus ◽  
Histological Analysis ◽  
Neoplastic Epithelium

scholarly journals Characteristics of non-neoplastic epithelium that appears within gastric cancer with and without Helicobacter pylori eradication: A retrospective study

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248333
Author(s):  
Hiroto Noda ◽  
Mitsuru Kaise ◽  
Ryuichi Wada ◽  
Eriko Koizumi ◽  
Kumiko Kirita ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Internal Surface ◽  
Length Ratio ◽  
Surface Type ◽  
Helicobacter Pylori Eradication ◽  
Primary Endpoints ◽  
Secondary Endpoints ◽  
Depressed Lesion ◽  
Neoplastic Epithelium ◽  
Gland Type

A non-neoplastic epithelium (NE) often appears in gastric cancer (GC). We explored the histological features of NE in comparison between HP-eradicated and HP-infected GCs. We enrolled 40 HP-eradicated and 40 HP-infected GCs matched by size, macroscopic and histological type. NE was classified into full gland type and surface type; the former was a non-neoplastic gland isolated within cancer, and the latter was NE on the surface of the cancer. Surface type was additionally divided into NE at the cancer margin (marginal surface type) and NE inside cancer (internal surface type). The primary endpoints were the frequency and the length ratio (the ratio to cancer length) of NE. The secondary endpoints were the relationships between NE and clinicopathological factors, including endoscopic findings of a gastritis-like appearance (GLA), reddish depressed lesion (RDL), and white nodular mucosa (WNM). The frequency and length ratio of the internal surface type in HP-eradicated GCs were significantly higher (82.5% vs 50%, P = 0.005) and larger (11.6 ± 10.6 vs 4.2 ± 9.9, P < 0.001) than those in HP-infected GCs, and the increase was more significant according to the passage of time since HP eradication. The frequency and length ratio of marginal surface type and full gland type were not significantly different between the two groups, but the coexistence of internal surface and full gland types was statistically significant (p < 0.001). The frequencies of GLA, RDLs, and WNM in HP-eradicated GCs were significantly higher than those in HP-infected GCs. GLA-positive GCs were covered more widely by internal surface type than GLA-negative GCs (13.3% vs. 6.6%, P = 0.003). Various types of NE were noted in gastric cancer, and the internal surface type of NE was shown to be significantly linked to HP-eradicated cancer and GLA.

PS02.025: CHARACTERISTICS OF SUPERFICIAL BASALOID SQUAMOUS CELL CARCINOMA TREATED BY ENDOSCOPIC RESECTION

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 127-127
Author(s):  
Tsuneo Oyama ◽  
Akiko Takahashi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Endoscopic Resection ◽  
Squamous Cell ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Basaloid Squamous Cell Carcinoma ◽  
En Bloc ◽  
Neoplastic Epithelium ◽  
Basaloid Squamous

Abstract Background Basaloid squamous cell carcinoma (BSCC) is a rare esophageal carcinoma. And the characteristics especially in early stage is unknown. Methods The aim of this study is to clarify the characteristics of superficial BSCC. Thirteen patients (9 males and 4 females) with BSCC treated by endoscopic resection (12 ESD and 1 EMRC) from January 2000 to March 2017 were enrolled in this retrospective study. The median age was 67 (57–83). The median follow-up period was 24 (12–115) months. T1a-EP/LPM and T1a-MM/T1b-SM1 without lymph duct invasion (LDI) was followed up. T1a-MM/T1b-SM1 with LDI or T1b-SM2 were treated by additional treatment (AT). Results 1. En-bloc resection and R0 resection rate was 100% and 100%, respectively. 2. Macroscopic type; 0-IIa, 0-IIb and 0-IIc was 4, 1 and 8, respectively. 3. The median tumor diameter was 27 (2–62) mm. 4. Invasion depth; T1a-LPM, T1a-MM/T1b-SM1, and T1b-SM2 was 3, 5 and 5, respectively. 5. Histological characteristics; All BSCC were covered by SCC or non-neoplastic squamous epithelium. 6. Endoscopic characteristics; SMT like appearance was found in 46% (6/13). Yellowish nodules were observed in 23% (3/13). This finding was observed, when BSCC exist superficial epithelial layer covered by thin non-neoplastic epithelium. 7. Prognosis A: T1a-LPM (N = 3). Two patients are alive without recurrence, and 1 patient died of other disease. B: T1a-MM/SM1 (N = 5). Two of 3 patients without LDI were followed up and alive. Remaining one patient wanted to be treated by CRT, and alive. Two patients had LVI, however they were followed up without AT because of patient's hope. One is alive, and another died of other disease. C: T1b-SM2 (N = 5). Two and one patients were treated by surgery and chemotherapy, respectively, and alive without recurrence. Remaining two patients were followed up without AT. One of 2 patients are alive without recurrence. Another patient dead of other disease. Conclusion 1. All of BSCC were covered by SCC or non-neoplastic epithelium. 2. SMT like appearance and yellowish nodules under squamous cell epithelium were the characteristic endoscopic findings. 3. 40% of T1aMM/T1bSM1 had LDI. It's higher than that of SCC. Therefore, En-bloc resection is necessary for the detailed histological examination. Disclosure All authors have declared no conflicts of interest.

scholarly journals Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours

2013 ◽  
Vol 66 (5) ◽  
pp. 386-391 ◽  
Author(s):  
Kenichi Harada ◽  
Yasunori Sato ◽  
Hiroko Ikeda ◽  
Maylee Hsu ◽  
Saya Igarashi ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Cell Line ◽  
Chromogranin A ◽  
Neuroendocrine Tumours ◽  
Neuroendocrine Differentiation ◽  
Biliary Tree ◽  
Neuroendocrine Marker ◽  
Cholangiocarcinoma Cell ◽  
Neoplastic Epithelium

AimsBiliary neuroendocrine tumours (NETs) are rare and mostly exist as a component of mixed adenoneuroendocrine carcinomas (MANECs). Although the NET component in biliary MANECs is generally more malignant and clinically more important to the prognosis than the ordinary adenocarcinomatous component, the histogenesis of biliary NET has not been clarified. In this study, the role of the Notch1-Hes1 signalling axis in the histogenesis of biliary NETs was examined.MethodsImmunohistochemistry for Notch1, its ligand Jagged1 and Hes1 was performed using surgical specimens from 11 patients with biliary MANEC. Moreover, after the knock-down of Notch1 mRNA expression in a cholangiocarcinoma cell line, the expression of chromogranin A (a neuroendocrine marker) and Ascl1 (a neuroendocrine-inducing molecule inhibited by activated Hes1) was examined by quantitative PCR.ResultsHistological examination revealed that the adenocarcinomatous components were predominately located at the luminal surface of the MANEC and the majority of stromal invasion involved NET components. Ordinary adenocarcinomas and non-neoplastic biliary epithelium constantly expressed Notch1, Jagged1 and Hes1, but the expression of Notch1 and Hes1 was decreased or absent in NET components, suggesting interference with the Notch1-Hes1 signalling axis in biliary NET. Moreover, in the cholangiocarcinoma cell line in which the expression of Notch1 mRNA was knocked down, the mRNA expression of Ascl1 and chromogranin A was increased.ConclusionsThe Notch1-Hes1 signalling axis suppresses neuroendocrine differentiation and maintains tubular/acinar features in adenocarcinoma and non-neoplastic epithelium in the biliary tree. Moreover, a disruption of this signalling axis may be associated with the tumourigenesis of NETs in biliary MANEC.

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