Human cytomegalovirus preferentially infects the neoplastic epithelium of colorectal cancer: A quantitative and histological analysis

2012 ◽  
Vol 54 (3) ◽  
pp. 240-244 ◽  
Author(s):  
Hsin-Pai Chen ◽  
Jeng-Kai Jiang ◽  
Cheng-Yu Chen ◽  
Teh-Ying Chou ◽  
Yen-Chung Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Human Cytomegalovirus ◽  
Histological Analysis ◽  
Neoplastic Epithelium

Human Cytomegalovirus Induced Immune Regulation Is Correlated With Poor Prognosis in Colorectal Cancer Patients

2021 ◽  
Author(s):  
Yangyang Fang ◽  
Qiongdan Wang ◽  
Kaizhao Huang ◽  
Mengyue Zhang ◽  
Shunjie Pei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Immune Function ◽  
Human Cytomegalovirus ◽  
Poor Prognosis ◽  
Hcmv Infection ◽  
Information Matrix ◽  
Clinical Information ◽  
Gene Expression Omnibus ◽  
Survival Outcomes ◽  
Survival Prognosis

Abstract Available evidence suggests that human cytomegalovirus (HCMV) infection may be implicated in the progression of colorectal cancer (CRC). However, the correlation between HCMV infection and survival outcomes in CRC patients is unclear. Here, we constructed a flow algorithm to identify HCMV sequences based on the RNA-seq data of CRC patients derived from Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). The patients' clinical information matrix was used to calculate Euclidean distance to filter out suitable patients not infected with HCMV, combining with the patient's survival outcome to reveal how HCMV infection is involved in CRC progression.HCMV infection is widespread in CRC patients., The prevalence of HCMV infection is ranging from 10% to 36% in 4 independent CRC datasets with infection being concentrated in carcinoma tissue rather than in normal tissue. In addition, HCMV positive patients had a poor survival prognosis, with three of the HCMV genes associated with poor patient survival outcomes, UL82, UL42 and UL117. Most importantly, we suppose that the regulation of immune function by HCMV may be the key to the poor prognosis of CRC patients. We found that HCMV infection was associated with poor prognosis in CRC patients and identified three prognosis associated HCMV genes. The regulation of immune function caused by HCMV infection was the key factor while HCMV positive CRC patients mostly presented a state of immunosuppression. This may provide new ideas for personalized treatment of CRC patients, especially in immunotherapy.

Histological analysis of colorectal cancer specimen in a tertiary hospital in Ghana: A retrospective study

2020 ◽  
Vol 12 (2) ◽  
pp. 40
Author(s):  
BabatundeM Duduyemi ◽  
WilliamG Ayibor ◽  
Emmanuel Asante ◽  
Ebenezer Owusu ◽  
FosterK Safo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Study ◽  
Histological Analysis ◽  
Tertiary Hospital ◽  
Cancer Specimen

scholarly journals Clinical significance of expression of human cytomegalovirus genes in colorectal cancer

2016 ◽  
Vol 24 (7) ◽  
pp. 1024
Author(s):  
Yun He ◽  
Meng-Si Ye ◽  
Yu-Hui Zhou ◽  
Hao Lin ◽  
Shou-Xing Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Significance ◽  
Human Cytomegalovirus

scholarly journals Association of CCR5Δ32 Deletion and Human Cytomegalovirus Infection With Colorectal Cancer in Tunisia

2021 ◽  
Vol 12 ◽  
Author(s):  
Hanen Chelbi ◽  
Refka Jelassi ◽  
Sarra Belfkih ◽  
Amor Ben Amor ◽  
Nasreddine Saidi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Human Cytomegalovirus ◽  
Healthy Subjects ◽  
Enzyme Linked Immunosorbent Assay ◽  
Potential Candidate ◽  
Serum Samples ◽  
Potential Candidate Gene ◽  
Tumor Tissues ◽  
Pcr Technology ◽  
Genetic Deletion

Background and objectives: Human cytomegalovirus (HCMV) and genetic polymorphisms of the chemokine receptor 5 have been suggested as factors associated with the progression of colorectal cancer (CRC). The aim of the study was to evaluate the associations of both CCR5Δ32 genetic deletion and/or HCMV virus infection with CRC in Tunisia. Materials and methods: The association between HCMV and CRC was validated by Nested PCR technology performed for HCMV and HCMV-specific serum IgG and IgM antibodies were investigated by enzyme-linked immunosorbent assay. Experiments were carried out on 40 tumor and 35 peri-tumor tissues, 100 blood from CRC patients and on 140 blood samples from healthy subjects and finaly serum samples of 80 patients with CRC and 100 healthy individuals. A conventional PCR has been optimized for the detection of CCR5Δ32 in100 CRC patients and 100 healthy subjects. Results: Our results show that HCMV is significantly active in 93% of patients compared to 60% in controls (p < 0.0001, OR = 8.85, 95% CI: 3.82 -20.50). Compared to the healthy controls, the titers of IgG and IgM antiCMV antibodies in CRC patients were significantly higher than in healthy subjects (p value < 0,0001 for IgG and IgM). Statistical analysis revealed a lack of association between CCR5Δ32 mutation and colorectal cancer (p = 0.788, OR = 1.265, 95% CI: 0.228-7.011). Conclusion: our data confirmed that the HCMV infection was related to the development of CRC and that CRC cells may be infected more favorably by HCMV. Given the importance of the CCR5 in inflammation and therefore CRC progression, further studies still needed to evaluate CCR5 role as a potential candidate gene for CRC susceptibility under other polymorphisms.

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