scholarly journals Glutamate Carboxypeptidase 2

2020 ◽  
Author(s):  
Keyword(s):  
Glutamate Carboxypeptidase

Design, Synthesis, and Pharmacological Evaluation of Glutamate Carboxypeptidase II (GCPII) Inhibitors Based on Thioalkylbenzoic Acid Scaffolds

2012 ◽  
Vol 55 (12) ◽  
pp. 5922-5932 ◽  
Author(s):  
Doris Stoermer ◽  
Dilrukshi Vitharana ◽  
Niyada Hin ◽  
Greg Delahanty ◽  
Bridget Duvall ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Glutamate Carboxypeptidase Ii ◽  
Pharmacological Evaluation ◽  
Glutamate Carboxypeptidase

S1 pocket of glutamate carboxypeptidase II: A new binding site for amyloid-β degradation

2013 ◽  
Vol 438 (4) ◽  
pp. 765-771 ◽  
Author(s):  
Suk Kyung Lee ◽  
Hyunyoung Kim ◽  
You-Hoon Cheong ◽  
Min-Ju Kim ◽  
Sangmee Ahn Jo ◽  
...  
Keyword(s):  
Binding Site ◽  
Amyloid Β ◽  
Glutamate Carboxypeptidase Ii ◽  
Glutamate Carboxypeptidase

PLASTOCHRON3/GOLIATHencodes a glutamate carboxypeptidase required for proper development in rice

2009 ◽  
Vol 58 (6) ◽  
pp. 1028-1040 ◽  
Author(s):  
Taiji Kawakatsu ◽  
Graziana Taramino ◽  
Jun-Ichi Itoh ◽  
Justin Allen ◽  
Yutaka Sato ◽  
...  
Keyword(s):  
Glutamate Carboxypeptidase

Structural Insight into the Pharmacophore Pocket of Human Glutamate Carboxypeptidase II⊥

2007 ◽  
Vol 50 (14) ◽  
pp. 3267-3273 ◽  
Author(s):  
Cyril Bařinka ◽  
Miroslava Rovenská ◽  
Petra Mlčochová ◽  
Klára Hlouchová ◽  
Anna Plechanovová ◽  
...  
Keyword(s):  
Glutamate Carboxypeptidase Ii ◽  
Structural Insight ◽  
Glutamate Carboxypeptidase ◽  
Insight Into

scholarly journals Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance

2021 ◽  
Vol 13 ◽  
Author(s):  
Dibyadeep Datta ◽  
Shannon N. Leslie ◽  
Elizabeth Woo ◽  
Nishita Amancharla ◽  
Ayah Elmansy ◽  
...  
Keyword(s):  
Working Memory ◽  
Memory Performance ◽  
Cognitive Disorders ◽  
Glutamate Carboxypeptidase Ii ◽  
Prefrontal Cortical ◽  
Aging Rat ◽  
Medial Pfc ◽  
Improved Performance ◽  
Glutamate Carboxypeptidase ◽  
Pentanedioic Acid

Glutamate carboxypeptidase II (GCPII) expression in brain is increased by inflammation, and reduces NAAG (N-acetyl aspartyl glutamate) stimulation of mGluR3 signaling. Genetic insults in this signaling cascade are increasingly linked to cognitive disorders in humans, where increased GCPII and or decreased NAAG-mGluR3 are associated with impaired prefrontal cortical (PFC) activation and cognitive impairment. As aging is associated with increased inflammation and PFC cognitive deficits, the current study examined GCPII and mGluR3 expression in the aging rat medial PFC, and tested whether GCPII inhibition with 2-(3-mercaptopropyl) pentanedioic acid (2-MPPA) would improve working memory performance. We found that GCPII protein was expressed on astrocytes and some microglia as expected from previous studies, but was also prominently expressed on neurons, and showed increased levels with advancing age. Systemic administration of the GCPII inhibitor, 2-MPPA, improved working memory performance in young and aged rats, and also improved performance after local infusion into the medial PFC. As GCPII inhibitors are well-tolerated, they may provide an important new direction for treatment of cognitive disorders associated with aging and/or inflammation.

scholarly journals Glutamate carboxypeptidase II (GCPII) inhibitor 2-PMPA reduces rewarding effects of the synthetic cathinone MDPV in rats: a role for N-acetylaspartylglutamate (NAAG)

2017 ◽  
Vol 234 (11) ◽  
pp. 1671-1681 ◽  
Author(s):  
Callum Hicks ◽  
Ryan A. Gregg ◽  
Sunil U. Nayak ◽  
Lee Anne Cannella ◽  
Giana J. Schena ◽  
...  
Keyword(s):  
Glutamate Carboxypeptidase Ii ◽  
Synthetic Cathinone ◽  
Glutamate Carboxypeptidase

scholarly journals Glutamate Carboxypeptidase II Inhibition Behaviorally and Physiologically Improves Pyridoxine-Induced Neuropathy in Rats

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e102936 ◽  
Author(s):  
Michelle C. Potter ◽  
Krystyna M. Wozniak ◽  
Noelle Callizot ◽  
Barbara S. Slusher
Keyword(s):  
Glutamate Carboxypeptidase Ii ◽  
Glutamate Carboxypeptidase

Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in mice

2011 ◽  
Vol 1371 ◽  
pp. 82-86 ◽  
Author(s):  
Yuto Takatsu ◽  
Yuko Fujita ◽  
Takashi Tsukamoto ◽  
Barbara S. Slusher ◽  
Kenji Hashimoto
Keyword(s):  
Prepulse Inhibition ◽  
Glutamate Carboxypeptidase Ii ◽  
Glutamate Carboxypeptidase ◽  
Orally Active

Glutamate Carboxypeptidase II (NAALADase) Inhibition as a Novel Therapeutic Strategy

2006 ◽  
pp. 327-337 ◽  
Author(s):  
Ajit G. Thomas ◽  
Krystyna M. Wozniak ◽  
Takashi Tsukamoto ◽  
David Calvin ◽  
Ying Wu ◽  
...  
Keyword(s):  
Therapeutic Strategy ◽  
Glutamate Carboxypeptidase Ii ◽  
Glutamate Carboxypeptidase ◽  
Novel Therapeutic

scholarly journals The calcium-binding site of human glutamate carboxypeptidase II is critical for dimerization, thermal stability, and enzymatic activity

2018 ◽  
Vol 27 (9) ◽  
pp. 1575-1584 ◽  
Author(s):  
Jakub Ptacek ◽  
Jana Nedvedova ◽  
Michal Navratil ◽  
Barbora Havlinova ◽  
Jan Konvalinka ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Enzymatic Activity ◽  
Binding Site ◽  
Calcium Binding ◽  
Calcium Binding Site ◽  
Glutamate Carboxypeptidase Ii ◽  
Glutamate Carboxypeptidase
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