scholarly journals Radioprotective Agent

2020 ◽  
Author(s):  
Keyword(s):  
Radioprotective Agent

scholarly journals Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent

2021 ◽  
Vol 22 (9) ◽  
pp. 4566
Author(s):  
Shin-ichi Hirano ◽  
Yusuke Ichikawa ◽  
Bunpei Sato ◽  
Haru Yamamoto ◽  
Yoshiyasu Takefuji ◽  
...  
Keyword(s):  
Radiation Damage ◽  
Molecular Hydrogen ◽  
Regulation Of Gene Expression ◽  
Animal Experiments ◽  
Radiation Energy ◽  
Water Radiolysis ◽  
Low Dose Radiation ◽  
Oxidizing Power ◽  
Radiation Induced ◽  
Radioprotective Agent

Although ionizing radiation (radiation) is commonly used for medical diagnosis and cancer treatment, radiation-induced damages cannot be avoided. Such damages can be classified into direct and indirect damages, caused by the direct absorption of radiation energy into DNA and by free radicals, such as hydroxyl radicals (•OH), generated in the process of water radiolysis. More specifically, radiation damage concerns not only direct damages to DNA, but also secondary damages to non-DNA targets, because low-dose radiation damage is mainly caused by these indirect effects. Molecular hydrogen (H2) has the potential to be a radioprotective agent because it can selectively scavenge •OH, a reactive oxygen species with strong oxidizing power. Animal experiments and clinical trials have reported that H2 exhibits a highly safe radioprotective effect. This paper reviews previously reported radioprotective effects of H2 and discusses the mechanisms of H2, not only as an antioxidant, but also in intracellular responses including anti-inflammation, anti-apoptosis, and the regulation of gene expression. In doing so, we demonstrate the prospects of H2 as a novel and clinically applicable radioprotective agent.

scholarly journals Radioprotective Effect of Hesperidin: A Systematic Review

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 370 ◽  
Author(s):  
Musa ◽  
Omyan ◽  
Esmaely ◽  
Shabeeb
Keyword(s):  
Clinical Trials ◽  
Survival Rates ◽  
Control Design ◽  
Case Control ◽  
Radioprotective Effect ◽  
Cellular Damage ◽  
Animal Cells ◽  
Meta Analyses ◽  
Late Side ◽  
Radioprotective Agent

Background and objectives: Ionizing radiation (IR) has been of immense benefit to man, especially for medical purposes (diagnostic imaging and radiotherapy). However, the risks of toxicity in healthy normal cells, leading to cellular damage as well as early and late side effects, have been major drawbacks. The aim of this study was to evaluate the radioprotective effect of hesperidin against IR-induced damage. Materials and Methods: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were applied in reporting this study. A search was conducted using the electronic databases PubMed, Scopus, Embase, Google Scholar, and www.ClinicalTrials.gov for information about completed or ongoing clinical trials. Results: From our search results, 24 studies involving rats, mice, and cultured human and animal cells were included. An experimental case—control design was used in all studies. The studies showed that the administration of hesperidin reduced oxidative stress and inflammation in all investigated tissues. Furthermore, it increased 30-day and 60-day survival rates and protected against DNA damage. The best radioprotection was obtained when hesperidin was administered before irradiation. Conclusions: The results of the included studies support the antioxidant, anti-inflammatory, and antiapoptotic abilities of hesperidin as a potential radioprotective agent against IR-induced damage. We recommend future clinical trials for more insights.

A STUDY OF THE PROTECTIVE ACTION OF SEROTONIN (5-HYDROXYTRYPTAMINE) AGAINST WHOLE-BODY X-IRRADIATION IN MICE WITH THE AID OF CHROMIUM 51

1963 ◽  
Vol 41 (2) ◽  
pp. 347-360 ◽  
Author(s):  
P. V. Vittorio ◽  
E. W. Wight ◽  
B. E. Sinnott
Keyword(s):  
Radiation Effect ◽  
Protective Action ◽  
Whole Body ◽  
X Irradiation ◽  
Initial Radiation ◽  
Radioprotective Agent

Studies were carried out to determine the effect of X-irradiation on the uptake of chromium 51 in different organs in the mouse. Experiments were also carried out to determine whether the initial radiation effect, if any, was lessened or the return to normal chromium 51 uptake accelerated when the animal was treated with a specific radioprotective agent (serotonin) prior to exposure to X-irradiation. If the assumption is made that early disturbances in Cr51content in different organs are a measure of the effect of various treatments and the return to normal Cr51content a measure of recovery, the results obtained could be indicative of changes caused by X-irradiation and those prevented or caused by serotonin.

scholarly journals Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo

2020 ◽  
Vol 62 (1) ◽  
pp. 34-45
Author(s):  
Hong Li ◽  
Yaru Yin ◽  
Jing Liu ◽  
Binghui Lu ◽  
Huimin Wan ◽  
...  
Keyword(s):  
B Lymphocyte ◽  
Tritiated Water ◽  
Intragastric Administration ◽  
Dna Oxidative Damage ◽  
Intracellular Ros ◽  
Endogenous Antioxidants ◽  
Production Industry ◽  
Radioprotective Agent

Abstract Radionuclide tritium is widely used in the nuclear energy production industry and creates a threat to human health through radiation exposure. Herein, the radioactive elimination and radioprotective effect of hydrogen-rich water (HRW), a potential antioxidant with various medical applications, on tritiated water (HTO) exposure, was studied in vitro and in vivo. Results showed that intragastric administration of HRW effectively promoted the elimination of urinary tritium, decreased the level of serum tritium and tissue-bound tritium (OBT), and attenuated the genetic damage of blood cells in mice exposed to HTO (18.5 MBq/kg). Pretreatment with HRW effectively reduces tritium accumulation in HTO-treated human blood B lymphocyte AHH-1 cells. In addition, the anti-oxidative properties of HRW could attenuate the increased intracellular ROS (such as O2•-, •OH and ONOO−), resulting in reversing the exhaustion of cellular endogenous antioxidants (reduced GSH and SOD), decreasing lipid peroxidation (MDA), relieving DNA oxidative damage, and depressing cell apoptosis and cytotoxicity induced by HTO exposure. In conclusion, HRW is expected to be an effective radioactive elimination agent through the competition effect of isotope exchange or a radioprotective agent by scavenging free radicals induced by HTO exposure.

scholarly journals l-Alpha Glycerylphosphorylcholine as a Potential Radioprotective Agent in Zebrafish Embryo Model

Zebrafish ◽  
2016 ◽  
Vol 13 (6) ◽  
pp. 481-488 ◽  
Author(s):  
Emília Rita Szabó ◽  
Imola Plangár ◽  
Tünde Tőkés ◽  
Imola Mán ◽  
Róbert Polanek ◽  
...  
Keyword(s):  
Zebrafish Embryo ◽  
Radioprotective Agent

scholarly journals Hydrogen as a New Class of Radioprotective Agent

2013 ◽  
Vol 9 (9) ◽  
pp. 887-894 ◽  
Author(s):  
Liren Qian ◽  
Jianliang Shen ◽  
Yunhai Chuai ◽  
Jianming Cai
Keyword(s):  
New Class ◽  
Radioprotective Agent

Fullerenol@nano-montmorillonite Nanocomposite as an Efficient Radioprotective Agent for Ameliorating Radioactive Duodenal Injury

2021 ◽  
pp. 131725
Author(s):  
Chengyan Wang ◽  
Maoru Zhao ◽  
Jiani Xie ◽  
Chao Ji ◽  
Zhengwei Leng ◽  
...  
Keyword(s):  
Duodenal Injury ◽  
Radioprotective Agent
Sign in / Sign up

Export Citation Format

Share Document