A STUDY OF THE PROTECTIVE ACTION OF SEROTONIN (5-HYDROXYTRYPTAMINE) AGAINST WHOLE-BODY X-IRRADIATION IN MICE WITH THE AID OF CHROMIUM 51

1963 ◽  
Vol 41 (2) ◽  
pp. 347-360 ◽  
Author(s):  
P. V. Vittorio ◽  
E. W. Wight ◽  
B. E. Sinnott
Keyword(s):  
Radiation Effect ◽  
Protective Action ◽  
Whole Body ◽  
X Irradiation ◽  
Initial Radiation ◽  
Radioprotective Agent

Studies were carried out to determine the effect of X-irradiation on the uptake of chromium 51 in different organs in the mouse. Experiments were also carried out to determine whether the initial radiation effect, if any, was lessened or the return to normal chromium 51 uptake accelerated when the animal was treated with a specific radioprotective agent (serotonin) prior to exposure to X-irradiation. If the assumption is made that early disturbances in Cr51content in different organs are a measure of the effect of various treatments and the return to normal Cr51content a measure of recovery, the results obtained could be indicative of changes caused by X-irradiation and those prevented or caused by serotonin.

A STUDY OF THE PROTECTIVE ACTION OF SEROTONIN (5-HYDROXYTRYPTAMINE) AGAINST WHOLE-BODY X-IRRADIATION IN MICE WITH THE AID OF CHROMIUM 51

1963 ◽  
Vol 41 (1) ◽  
pp. 347-360 ◽  
Author(s):  
P. V. Vittorio ◽  
E. W. Wight ◽  
B. E. Sinnott
Keyword(s):  
Radiation Effect ◽  
Protective Action ◽  
Whole Body ◽  
X Irradiation ◽  
Initial Radiation ◽  
Radioprotective Agent

Studies were carried out to determine the effect of X-irradiation on the uptake of chromium 51 in different organs in the mouse. Experiments were also carried out to determine whether the initial radiation effect, if any, was lessened or the return to normal chromium 51 uptake accelerated when the animal was treated with a specific radioprotective agent (serotonin) prior to exposure to X-irradiation. If the assumption is made that early disturbances in Cr51content in different organs are a measure of the effect of various treatments and the return to normal Cr51content a measure of recovery, the results obtained could be indicative of changes caused by X-irradiation and those prevented or caused by serotonin.

Protective effect of artificially induced ‘hibernation’ against lethal doses of whole body x-irradiation in CF1 male mice

1959 ◽  
Vol 196 (6) ◽  
pp. 1211-1213 ◽  
Author(s):  
Sondra M. Kuskin ◽  
S. C. Wang ◽  
Roberts Rugh
Keyword(s):  
Protective Action ◽  
Lethal Dose ◽  
Lethal Effect ◽  
The Body ◽  
Whole Body ◽  
Protective Mechanism ◽  
Slight Reduction ◽  
Male Mice ◽  
Degree Of Protection ◽  
X Irradiation

Hypothermia induced by the use of neuroplegic drugs such as Hydergine, chlorpromazine or promethazine, followed by refrigeration, does not significantly enhance the protective action afforded by refrigeration alone against the lethal dose of whole body x-irradiation in CF1 male mice. The neuroplegic drugs, without refrigeration, provide a slight degree of protection, probably due to the slight reduction in the body temperature. It appears that the action of hypothermia as a protective mechanism depends not on depression of metabolism alone, but on a general depression of bodily processes. Urethane, in conjunction with refrigeration, appears to augment the lethal effect of x-irradiation in the CF1 strain of male mice.

RECOVERY FROM LETHAL X-RAY DAMAGE DURING DELAYED IMPLANTATION IN THE RAT

1971 ◽  
Vol 51 (4) ◽  
pp. 657-663 ◽  
Author(s):  
W. F. WARD ◽  
R. K. MEYER ◽  
R. C. WOLF
Keyword(s):  
Radiation Effect ◽  
Whole Body ◽  
Irradiation Damage ◽  
Embryonic Survival ◽  
Developmental Abnormalities ◽  
X Ray ◽  
Delayed Implantation ◽  
Stage Of Development ◽  
X Irradiation ◽  
Rate Of Recovery

SUMMARY Rats were exposed to either 300 or 500 röntgen (R) acute whole-body X-irradiation on the 5th day of delayed pregnancy induced by ovariectomy. From 0 to 8 days after irradiation, implantation was induced by the administration of oestrogen. Foetal survival to the 20th day of development was used as an index of radiation effect. If oestrogen was given immediately after exposure to 300 R, or 12 h later, only 30–35% of the embryos survived, significantly less (P < 0·01) than the non-irradiated control values of 74–79%. When implantation was postponed for 24 h or more, embryonic survival ranged from 57 to 64% and was not significantly different from that of controls. After exposure to 500 R X-irradiation, embryonic survival increased linearly from 2% to a maximum of 41% as the interval between irradiation and oestrogen administration increased from 0 to 48 h. Embryonic survival never reached control levels after 500 R, regardless of the interval between irradiation and implantation. The irradiation regimens also induced developmental abnormalities, doubled the incidence of dead foetuses (death at a late stage of development), and significantly reduced foetal and placental weights at autopsy. The results confirm that recovery from potentially lethal X-irradiation damage can occur during delayed implantation, and demonstrate that both the extent and the rate of recovery are functions of the radiation dose.

Protective Action of Carbon Monoxide in Mammalian Whole-Body X-Irradiation

1955 ◽  
Vol 3 (2) ◽  
pp. 157 ◽  
Author(s):  
Eugene B. Konecci ◽  
William F. Taylor ◽  
Syrrel S. Wilks
Keyword(s):  
Carbon Monoxide ◽  
Protective Action ◽  
Whole Body ◽  
X Irradiation
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