Bethanechol Chloride

2020 ◽  
Author(s):  
Keyword(s):  
Bethanechol Chloride

Further Observations on the Cystometric and Uroflowmetric Effects of Bethanechol Chloride on the Human Bladder

1979 ◽  
Vol 122 (6) ◽  
pp. 775-777 ◽  
Author(s):  
L. Paul Sonda ◽  
Charles Gershon ◽  
Ananias C. Diokno ◽  
Jack Lapides
Keyword(s):  
Human Bladder ◽  
Bethanechol Chloride

The Effect of Oral Bethanechol Chloride on the Cystometrogram of the Normal Male Adult

1978 ◽  
Vol 120 (3) ◽  
pp. 330-331 ◽  
Author(s):  
Alan J. Wein ◽  
Philip M. Hanno ◽  
Dennis O. Dixon ◽  
David M. Raezer ◽  
George S. Benson
Keyword(s):  
Normal Male ◽  
Male Adult ◽  
Bethanechol Chloride

Effect of thiamine deficiency on canine gastric secretion of acid

1959 ◽  
Vol 197 (2) ◽  
pp. 253-256 ◽  
Author(s):  
Marjorie K. Lavers ◽  
Patricia A. Stefanik ◽  
Charles F. Code
Keyword(s):  
Body Weight ◽  
Hydrochloric Acid ◽  
Gastric Mucosa ◽  
Gastric Secretion ◽  
Thiamine Deficiency ◽  
Acid Output ◽  
Nervous Stimulation ◽  
Deficiency State ◽  
Bethanechol Chloride ◽  
Secretory Capacity

A study was undertaken to determine the effect of thiamine deficiency on the hydrochloric acid output of vagally denervated gastric pouches (Heidenhain-type) and vagally innervated gastric pouches (Pavlov-type) in dogs. Responses of both types of pouches to injection of 0.05 mg of histamine/kg of body weight and the maximal secretory capacity of both types after histamine were unaltered during the deficiency state. A degree of thiamine deficiency sufficient to produce anorexia and neuritis was without effect on the secretory response of canine gastric mucosa to histamine. The hydrochloric acid output of vagally innervated pouches during nervous stimulation caused by insulin-induced hypoglycemia was drastically reduced as soon as thiamine deficiency developed, while the response to bethanechol chloride was little, if at all, affected. It is concluded that the vagal secretory mechanism participates in the general neural failure of thiamine deficiency and that this failure most likely is in the neurons of the vagal nuclei.

Stimulating intestinal afferents reflexly activates cardiovascular system in cats

1988 ◽  
Vol 254 (2) ◽  
pp. H354-H360 ◽  
Author(s):  
G. A. Ordway ◽  
K. R. Boheler ◽  
J. C. Longhurst
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular System ◽  
Peripheral Resistance ◽  
Left Ventricular Pressure ◽  
Cardiovascular Effects ◽  
Cardiovascular Responses ◽  
Left Ventricular ◽  
Dose Dependent Fashion ◽  
Visceral Smooth Muscle ◽  
Bethanechol Chloride

Capsaicin and bradykinin stimulate afferents from certain viscera to reflexly activate the cardiovascular system; however, whether these agents evoke similar reflex responses when applied topically to the intestine is not known. Therefore, in cats anesthetized with methoxyflurane, we applied capsaicin (10 micrograms) or bradykinin (0.5 microgram) to the serosal surface of the jejunum. Additionally, we topically applied bethanechol chloride, a synthetic choline ester with little direct cardiovascular effects, to evoke marked contraction of the smooth muscle of the jejunum. Capsaicin evoked significant (P less than 0.05) increases in mean arterial pressure (105 +/- 4 to 119 +/- 4 mmHg, mean +/- SE), first derivative left ventricular pressure (dP/dt) at 40 mmHg (2,698 +/- 134 to 3,105 +/- 155 mmHg/s), systemic vascular resistance (0.63 +/- 0.15 to 0.68 +/- 0.15 peripheral resistance units), and heart rate (196 +/- 14 to 205 +/- 15 beats/min), whereas aortic flow did not change. In a dose-dependent fashion, bradykinin and bethanechol each caused cardiovascular activation as well as a marked contraction of the smooth muscle in the segment of jejunum to which they were applied. In contrast, capsaicin produced no detectable contraction of visceral smooth muscle. Removal of the celiac and superior mesenteric ganglia abolished the cardiovascular responses evoked by capsaicin and bradykinin. Thus, in cats, stimulating intestinal afferents by topically applying capsaicin or bradykinin reflexly activates the cardiovascular system. Furthermore, although mechanoreceptors may contribute to the responses evoked by bradykinin and bethanechol, the capsaicin-related responses likely are mediated exclusively by chemically sensitive receptors.

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