Effect of Nicotine Hydrogen Tartrate on Gastric Secretion of Normal and Vagotomized Rats Stimulated with Histamine Pentagastrin and Bethanechol Chloride

Digestion ◽  
1974 ◽  
Vol 10 (6) ◽  
pp. 393-401 ◽  
Author(s):  
K. Kowalewski
Keyword(s):  
Gastric Secretion ◽  
Bethanechol Chloride

Effect of thiamine deficiency on canine gastric secretion of acid

1959 ◽  
Vol 197 (2) ◽  
pp. 253-256 ◽  
Author(s):  
Marjorie K. Lavers ◽  
Patricia A. Stefanik ◽  
Charles F. Code
Keyword(s):  
Body Weight ◽  
Hydrochloric Acid ◽  
Gastric Mucosa ◽  
Gastric Secretion ◽  
Thiamine Deficiency ◽  
Acid Output ◽  
Nervous Stimulation ◽  
Deficiency State ◽  
Bethanechol Chloride ◽  
Secretory Capacity

A study was undertaken to determine the effect of thiamine deficiency on the hydrochloric acid output of vagally denervated gastric pouches (Heidenhain-type) and vagally innervated gastric pouches (Pavlov-type) in dogs. Responses of both types of pouches to injection of 0.05 mg of histamine/kg of body weight and the maximal secretory capacity of both types after histamine were unaltered during the deficiency state. A degree of thiamine deficiency sufficient to produce anorexia and neuritis was without effect on the secretory response of canine gastric mucosa to histamine. The hydrochloric acid output of vagally innervated pouches during nervous stimulation caused by insulin-induced hypoglycemia was drastically reduced as soon as thiamine deficiency developed, while the response to bethanechol chloride was little, if at all, affected. It is concluded that the vagal secretory mechanism participates in the general neural failure of thiamine deficiency and that this failure most likely is in the neurons of the vagal nuclei.

Effects of KCl and insulin on benzimidazole-inhibited canine gastric secretion

1983 ◽  
Vol 245 (6) ◽  
pp. G739-G744
Author(s):  
B. I. Hirschowitz ◽  
J. Fong
Keyword(s):  
Gastric Secretion ◽  
Parietal Cell ◽  
Acid Output ◽  
Gastric Fistula ◽  
Large Decrease ◽  
Pepsin Secretion ◽  
K Secretion ◽  
Inhibited Acid ◽  
K Concentration ◽  
Bethanechol Chloride

The final step in acid secretion is believed to result from the H+-K+-ATPase-mediated exchange of H+ in the parietal cell, with K+ in the lumen. To study the K+ secretion we used Picoprazole and insulin separately and together to inhibit gastric secretion stimulated in gastric fistula dogs with histamine (100 micrograms X kg-1 X h-1). Picoprazole, a substituted benzimidazole (750 mg/kg), reduced gastric H+ concentration and volume with a rise in K+ concentration [( K+]) to 20–25 meq/l. Insulin alone inhibited acid output to the same extent as Picoprazole but with a marked fall in [K+]. Insulin (0.6 U/kg) given with Picoprazole did not alter inhibition of H+ but prevented the large decrease in gastric juice [K+]. An injection of KCl (1 meq/kg) 1 h after Picoprazole did not alter the effects of the inhibitor. Pepsin secretion after insulin was delayed by Picoprazole, whereas during bethanechol chloride infusion (80 micrograms X kg-1 X h-1) pepsin output was reduced for a shorter period and to a lesser extent than acid. We concluded that insulin affects gastric H+ and K+ secretion by a mechanism not related to H+-K+-ATPase and that Picoprazole affects pepsin secretion probably indirectly via its effect on the parietal cell, where its action is quite consistent with an effect limited to inhibition of the H+-K+-ATPase of the parietal cell.

Studies in Gastric Secretion: Attempts to Produce Histamine In Vivo as a Secretory Stimulant

1952 ◽  
Vol 22 (4) ◽  
pp. 623-627
Author(s):  
I.H. Einsel ◽  
E. Nola Nixon ◽  
J.M. Rogoff
Keyword(s):  
Gastric Secretion

A Comparison of Fats of Varying Saturation as Inhibitors of Canine Gastric Secretion

1963 ◽  
Vol 45 (5) ◽  
pp. 638-643 ◽  
Author(s):  
James F. Long ◽  
Frank P. Brooks ◽  
David J. Sandweiss
Keyword(s):  
Gastric Secretion

Studies of the Parenteral and Topical Effects of Antihistamines on Gastric Secretion

1958 ◽  
Vol 35 (1) ◽  
pp. 1-15 ◽  
Author(s):  
H. Ragins ◽  
E.P. Benditt ◽  
H.B. Greenlee ◽  
L.R. Dragstedt
Keyword(s):  
Gastric Secretion

Inhibition of Basal and Postprandial Gastric Secretion by Poldine and Atropine in Patients with Peptic Ulcer

1962 ◽  
Vol 43 (4) ◽  
pp. 400-406 ◽  
Author(s):  
Robert D. Mitchell ◽  
J.N. Hunt ◽  
Morton I. Grossman
Keyword(s):  
Peptic Ulcer ◽  
Gastric Secretion
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