scholarly journals Skin Photosensitivity

2020 ◽  
Author(s):  
Keyword(s):  
Skin Photosensitivity

scholarly journals Photodynamic Therapy of Lung Cancer With Bronchial Artery Infusion of Photofrin

1996 ◽  
Vol 2 (4) ◽  
pp. 203-206 ◽  
Author(s):  
Tetsuya Okunaka ◽  
Harubumi Kato ◽  
Chimori Konaka ◽  
Kinya Furukawa ◽  
Masahiko Harada ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Early Stage ◽  
Bronchial Artery ◽  
Arterial Infusion ◽  
Early Stage Lung Cancer ◽  
Hospitalization Period ◽  
Bronchial Arterial Infusion ◽  
Skin Photosensitivity ◽  
Stage Lung Cancer

Photodynamic therapy (PDT) utilizing Photofrin is proving to be effective for the treatment of early stage lung cancer. However, wider clinical applications of Photofrin as a photosensitizer for various cancers are hampered by potentially serious and prolonged skin photosensitivity. To prevent these side effects and reduce the hospitalization period, we recently gave reduced doses of Photofrin by bronchial arterial infusion. Five patients with endoscopically evaluated minimally invasive carcinoma of the lung were given 0.7 mg/kg of Photofrin by bronchial arterial infusion 48 hr before PDT. Complete remission was obtained in all 5 cases and no case showed skin photosensitivity when exposed to sunlight under careful surveillance at one week after PDT.

PHOTODYNAMIC ACTIVITIES and SKIN PHOTOSENSITIVITY OF THE bis(DIMETHYLTHEXYLSILOXY)SILICON 2,3-NAPHTHALOCYANINE IN MICE

2008 ◽  
Vol 62 (6) ◽  
pp. 1058-1065 ◽  
Author(s):  
Nicole Brasseur ◽  
Rene Ouellet ◽  
Karina Lewis ◽  
William R. Potter ◽  
Johan E. van Lier
Keyword(s):  
Skin Photosensitivity

Behavioral and Neurophysiological Demonstration of a Lateralis Skin Photosensitivity in Larval Sea Lampreys

1991 ◽  
Vol 161 (1) ◽  
pp. 97-117 ◽  
Author(s):  
MARK RONAN ◽  
DAVID BODZNICK
Keyword(s):  
Spontaneous Activity ◽  
Lateral Line ◽  
Lateral Line Nerve ◽  
Medial Nucleus ◽  
Posterior Lateral Line ◽  
Behavioral Studies ◽  
Sea Lampreys ◽  
Response Thresholds ◽  
The Brain ◽  
Skin Photosensitivity

Larval lampreys respond to skin illumination with a delayed burst of swimming in an attempt to escape the light. The photoresponse, which is independent of the lateral eyes and pineal organs, is most readily elicited by light shone on the tail. Behavioral studies in larval lampreys demonstrate that photosensory afferents innervating the tail are carried by a trunk lateral line nerve supplying regions caudal to the head. The present results confirm that bilateral transection of this nerve in larval sea lampreys markedly diminishes the photoresponse. The trunk lateral line nerve consists of the recurrent ramus of the anterior lateral line nerve and a ramus of the posterior lateral line nerve. Bilateral transection of the recurrent ramus does not affect the photoresponse, indicating that lateralis photosensory afferents enter the brain via the posterior lateral line nerve and terminate in the medial octavolateralis nucleus. Photosensory units were subsequently recorded in the trunk lateral line nerve, posterior lateral line nerve and the lateral line area of the medulla. Medullary photosensory units were localized to the medial nucleus, previously regarded as the primary mechanosensory nucleus. Photosensory units in lateral line nerves and the brain exhibited low, irregular spontaneous activity and, after latencies of 17–4 s, responded to tail illumination with repeated impulse bursts. Response thresholds were 0.1-0.9 mWcm−2. Responses to sustained illumination were slowly adapting. A skin photosense is thus an additional lateralis modality in lampreys.

scholarly journals Neonatal Hemolytic Anemia Due to Inherited Harderoporphyria: Clinical Characteristics and Molecular Basis

Blood ◽  
1998 ◽  
Vol 91 (4) ◽  
pp. 1453-1457 ◽  
Author(s):  
J. Lamoril ◽  
H. Puy ◽  
L. Gouya ◽  
R. Rosipal ◽  
V. Da Silva ◽  
...  
Keyword(s):  
Hemolytic Anemia ◽  
Neuropsychiatric Symptoms ◽  
Point Mutations ◽  
Clinical Manifestations ◽  
Neurological Dysfunction ◽  
Compound Heterozygous ◽  
Variant Form ◽  
Functional Protein ◽  
Main Site ◽  
Skin Photosensitivity

Abstract Porphyrias, a group of inborn errors of heme synthesis, are classified as hepatic or erythropoietic according to clinical data and the main site of expression of the specific enzymatic defect. Hereditary coproporphyria (HC) is an acute hepatic porphyria with autosomal dominant inheritance caused by deficient activity of coproporphyrinogen III oxidase (COX). Typical clinical manifestations of the disease are acute attacks of neurological dysfunction; skin photosensitivity may also be present. We report a variant form of HC characterized by a unifying syndrome in which hematologic disorders predominate: harderoporphyria. Harderoporphyric patients exhibit jaundice, severe chronic hemolytic anemia of early onset associated with hepatosplenomegaly, and skin photosensitivity. Neither abdominal pain nor neuropsychiatric symptoms are observed. COX activity is markedly decreased. In a first harderoporphyric family, with three affected siblings, a homozygous K404E mutation has been previously characterized. In the present study, molecular investigations in a second family with neonatal hemolytic anemia and harderoporphyria revealed two heterozygous point mutations in the COX gene. One allele bore the missense mutation K404E previously described. The second allele bore an A→G transition at the third position of the donor splice site in intron 6. This new COX gene mutation resulted in exon 6 skipping and the absence of functional protein production. In contrast with other COX gene defects that produce the classical hepatic porphyria presentation, our data suggest that the K404E substitution (either in the homozygous or compound heterozygous state associated with a mutation leading to the absence of functional mRNA or protein) is responsible for the specific hematologic clinical manifestations of harderoporphyria.

SKIN PHOTOSENSITIVITY: DURATION and INTENSITY FOLLOWING INTRAVENOUS HEMATOPORPHYRIN DERIVATES, HpD and DHE

1987 ◽  
Vol 46 (5) ◽  
pp. 925-928 ◽  
Author(s):  
Nicholas Razum ◽  
Oscar J. Balchum ◽  
A. Edward Profio ◽  
Felix Carstens
Keyword(s):  
Skin Photosensitivity

Reduced Skin Photosensitivity with meta-Tetra(hydroxyphenyl)chlorin-Loaded Micelles Based on a Poly(2-ethyl-2-oxazoline)-b-poly(d,l-lactide) Diblock Copolymer in Vivo

2010 ◽  
Vol 7 (4) ◽  
pp. 1244-1253 ◽  
Author(s):  
Ming-Jium Shieh ◽  
Cheng-Liang Peng ◽  
Wei-Lun Chiang ◽  
Chau-Hui Wang ◽  
Chia-Yen Hsu ◽  
...  
Keyword(s):  
Diblock Copolymer ◽  
Skin Photosensitivity

Phase I and Pharmacokinetic Study of Photodynamic Therapy for High-Grade Gliomas Using a Novel Boronated Porphyrin

2001 ◽  
Vol 19 (2) ◽  
pp. 519-524 ◽  
Author(s):  
Mark A. Rosenthal ◽  
Bhadu Kavar ◽  
John S. Hill ◽  
Denis J. Morgan ◽  
Roger L. Nation ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Recommended Dose ◽  
Pharmacokinetic Parameters ◽  
Toxicity Profile ◽  
Intracranial Tumors ◽  
Time Curve ◽  
Concentration Time ◽  
Nonhematologic Toxicity ◽  
Dose Limiting Toxicity ◽  
Skin Photosensitivity

PURPOSE: To determine the recommended dose, toxicity profile, and pharmacokinetics of a novel boronated porphyrin (BOPP) for photodynamic therapy (PDT) of intracranial tumors. PATIENTS AND METHODS: BOPP was administered alone in increasing doses (0.25, 0.5, 1.0, 2.0, 4.0, or 8.0 mg/kg) preoperatively in patients with intracranial tumors undergoing postresection PDT until dose-limiting toxicity (DLT) was observed. RESULTS: Twenty-nine assessable patients with intracranial tumors received BOPP intravenously 24 hours before surgery. The recommended dose was 4 mg/kg. Dose escalation was limited by thrombocytopenia. The most common nonhematologic toxicity was skin photosensitivity. Pharmacokinetic parameters showed increased area under the plasma concentration-time curve and maximum concentration with increased dose. Tumor BOPP concentrations also increased with increased dose. CONCLUSION: BOPP at a dose of 4 mg/kg was well tolerated. DLT was thrombocytopenia, and photosensitivity was the only other toxicity of note. The efficacy of PDT using BOPP requires further exploration.

scholarly journals Photochemistry of Lipofuscin and the Interplay of UVA and Visible Light in Skin Photosensitivity

2018 ◽  
Author(s):  
Carolina Santacruz-Perez ◽  
Paulo Newton Tonolli ◽  
Felipe Gustavo Ravagnani ◽  
Maurício S. Baptista
Keyword(s):  
Visible Light ◽  
Skin Photosensitivity
Sign in / Sign up

Export Citation Format

Share Document